Abstract: Provided herein are metabolites and methods of using the metabolites for diagnosing and treating Autism Spectrum Disorder (ASD) in a subject with a gastrointestinal problem, for determining a personalized treatment protocol for the subject, and for monitoring the therapeutic effect of an ASD treatment protocol in the subject being treated with the ASD treatment protocol.

Abstract: Diagnostic metabolites and methods of using the metabolites for the diagnosis of autism spectrum disorder (ASD) are provided. The metabolites comprise a collection of 47 metabolites that were significantly different between the autistic and typically developing groups, and combinations of two or more of the metabolites are used to accurately diagnose ASD.

Abstract: According to one aspect of the presently disclosed subject there is provided a computerized method for scoring performance of a move of a trainee in a trainee frame input in relation to a move of a trainer in a trainer video wherein the trainer move includes at least one trainer keyframe. The method comprising obtaining a trainee frame input comprising a trainee move, the trainee move comprising a plurality of trainee frames, based on the at least one trainer keyframe, processing the plurality of trainee frames to provide a move performance score, indicative of the performance of the trainee move in relation to the trainer move, with respect to at least one aspect of the performance. In some examples, the aspects can be one of a similarity aspect, a timing aspect, or a motion dynamics aspect or a combination thereof.

Abstract: According to one aspect of the presently disclosed subject there is provided a computerized method for scoring performance of a move of a trainee in a trainee frame input in relation to a move of a trainer in a trainer video wherein the trainer move includes at least one trainer keyframe. The method comprising obtaining a trainee frame input comprising a trainee move, the trainee move comprising a plurality of trainee frames, based on the at least one trainer keyframe, processing the plurality of trainee frames to provide a move performance score, indicative of the performance of the trainee move in relation to the trainer move, with respect to at least one aspect of the performance. In some examples, the aspects can be one of a similarity aspect, a timing aspect, or a motion dynamics aspect or a combination thereof.

Abstract: Fisher discriminant analysis is performed on data sets of typically developing (TD) individuals and data sets of autism spectrum disorder (ASD) individuals to produce a model that classifies TD individuals from ASD individuals. The ASD data sets include pre-treatment folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathway metabolic profile data and post-treatment folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathway metabolic profile data for patients receiving one or more ASD treatments. Changes in adaptive behavior are predicted by utilizing regression of changes in adaptive behavior and changes in biochemical measurements observed in the data sets. Thus, the system can be used to predict the effectiveness of a given course of treatment for an ASD patient based on measured metabolite data of that patient, or to predict the overall effectiveness of a clinical trial based on metabolite data for the trial participants.

Abstract: Provided herein are methods of obtaining and applying measurements of metabolites to diagnosing ASD in a subject, particularly children, with high specificity and sensitivity. The metabolites can be measured in urine, serum, and whole blood samples.

Abstract: Provided herein are methods of obtaining and applying measurements of metabolites to quantifying maternal risk of having a child with autism spectrum disorder (ASD), with high specificity and sensitivity.

Abstract: Provided herein are metabolites and methods of using the metabolites for diagnosing and treating Autism Spectrum Disorder (ASD) in a subject with a gastrointestinal problem, for determining a personalized treatment protocol for the subject, and for monitoring the therapeutic effect of an ASD treatment protocol in the subject being treated with the ASD treatment protocol.

Abstract: Fisher discriminant analysis is performed on data sets of typically developing (TD) individuals and data sets of autism spectrum disorder (ASD) individuals to produce a model that classifies TD individuals from ASD individuals. The ASD data sets include pre-treatment folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathway metabolic profile data and post-treatment folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathway metabolic profile data for patients receiving one or more ASD treatments. Changes in adaptive behavior are predicted by utilizing regression of changes in adaptive behavior and changes in biochemical measurements observed in the data sets. Thus, the system can be used to predict the effectiveness of a given course of treatment for an ASD patient based on measured metabolite data of that patient, or to predict the overall effectiveness of a clinical trial based on metabolite data for the trial participants.

Abstract: Computed tomography (CT) screening, diagnosis, or another image analysis tasks are performed using one or more networks and/or algorithms to either integrate complementary tomographic image reconstructions and radiomics or map tomographic raw data directly to diagnostic findings in the machine learning framework. One or more reconstruction networks are trained to reconstruct tomographic images from a training set of CT projection data. One or more radiomics networks are trained to extract features from the tomographic images and associated training diagnostic data. The networks/algorithms are integrated into an end-to-end network and trained. A set of tomographic data, e.g., CT projection data, and other relevant information from an individual is input to the end-to-end network, and a potential diagnosis for the individual based on the features extracted by the end-to-end network is produced.

Abstract: Computed tomography (CT) screening, diagnosis, or another image analysis tasks are performed using one or more networks and/or algorithms to either integrate complementary tomographic image reconstructions and radiomics or map tomographic raw data directly to diagnostic findings in the machine learning framework. One or more reconstruction networks are trained to reconstruct tomographic images from a training set of CT projection data. One or more radiomics networks are trained to extract features from the tomographic images and associated training diagnostic data. The networks/algorithms are integrated into an end-to-end network and trained. A set of tomographic data, e.g., CT projection data, and other relevant information from an individual is input to the end-to-end network, and a potential diagnosis for the individual based on the features extracted by the end-to-end network is produced.

Abstract: Methods and systems for detecting an autism state are disclosed. A plurality of data arrays are received, each including a plurality of values. Each of the plurality of values represent a concentration of a different metabolite. A score for each of the plurality of data arrays is calculated based on a relationship between the plurality of values of each of the respective plurality of data arrays. The score for each of the plurality of data arrays is classified into an autism class and a neurotypical class. A test score for a test data array is calculated based on a relationship between the plurality of test values and can then be grouped into one of the autism class and the neurotypical class. The system thus can use biomarkers identified in a metabolic pathway, such as abnormalities in folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS), to identify patients with a high likelihood of having autism.

Abstract: A blade wheel consisting of sheet metal for use in motor vehicle refrigerant pumps has blades that are cut out of a disk and pitched and base disk segments that lie adjacent to the blades and remain between the latter. The blade wheel is formed by at least two different blade wheel elements which are provided with cut out, pitched blades, are interconnected in a fixed manner and are arranged so that their respective base disk segments are offset in relation to one another, forming a gap therebetween, the elements thus forming a common bottom disk. A hub sleeve is provided in the center of one of these blade wheel elements (the hub disk), and the center of the other blade wheel element or elements (the bore disk or disks) is provided with a hub sleeve receiving bore, which can be pushed onto the casing of the hub sleeve.

Abstract: The invention relates to a rotary pump (1) including a rotor (3) arranged in a closed pump housing (2) which is in operative connection with a drive (5) for the pumping of a fluid (4), wherein an inlet opening (6) is provided at the pump housing (2) for the intake of the fluid (4) into the pump housing (2) and an outlet opening (7) is provided at the pump housing (2) for conveying the fluid (4) out of the pump housing into a storage container (8) which is at least partially filled with the fluid (4). In accordance with the invention the outlet opening (7) is arranged and designed at the pump housing in such a way that the fluid (4) can be conveyed out of the pump housing (2) through the outlet opening (7) to the storage container (8) directly and free of ducting. The invention further relates to a hydrodynamic mixer (100) with a rotary pump (1) in accordance with the invention and also to the use of the rotary pump (1) and of the hydrodynamic mixer (100) for the processing of a fluid (4).

Abstract: The invention relates to a blade wheel consisting of sheet metal for use in motor vehicle refrigerant pumps. The aim of the invention is to develop a novel blade wheel consisting of sheet metal for use in motor vehicle refrigerant pumps which, aside from a plurality of blades, also has a high blade height, thus ensuring a high throughput. Moreover, it also has smooth running properties without re-machining and, furthermore, also without re-machining, ensures an optimum sealing gap with respect to the housing. At the same time, it can always be produced simply and cost-effectively with an open construction (without an end plate) as well as with a closed construction (with an end plate). In addition, it is characterized by a high pumping efficiency. The inventive blade wheel (1) consisting of sheet metal for use in motor vehicle refrigerant pumps has blades (3) that are cut out of a disk and pitched and base disk segments (4) that lie adjacent to the blades (3) and remain between the latter (3).

Abstract: The invention relates to a rotary pump (1) including a rotor (3) arranged in a closed pump housing (2) which is in operative connection with a drive (5) for the pumping of a fluid (4), wherein an inlet opening (6) is provided at the pump housing (2) for the intake of the fluid (4) into the pump housing (2) and an outlet opening (7) is provided at the pump housing (2) for conveying the fluid (4) out of the pump housing into a storage container (8) which is at least partially filled with the fluid (4). In accordance with the invention the outlet opening (7) is arranged and designed at the pump housing in such a way that the fluid (4) can be conveyed out of the pump housing (2) through the outlet opening (7) to the storage container (8) directly and free of ducting. The invention further relates to a hydrodynamic mixer (100) with a rotary pump (1) in accordance with the invention and also to the use of the rotary pump (1) and of the hydrodynamic mixer (100) for the processing of a fluid (4).

Abstract: The invention is directed to a delivery system for delivering a medical device. The delivery system includes an inner member having a proximal end and a distal end. The inner member defines a longitudinal axis between the proximal end and the distal end. A tip is formed at the distal end of the inner member. A bumper is freely disposed on the inner member. The bumper has a proximal end and a distal end. A seat is defined between the tip and the distal end of the bumper. Additionally, a sheath is disposed about the inner member, the sheath having a proximal end and a distal end. The sheath is movable from a first sheath position substantially covering the seat, and a second sheath position axially offset to expose the seat. The invention also includes a handle in contact with the proximal end of the inner member.

Abstract: The invention is directed to a delivery system for delivering a medical device. The delivery system includes an inner member having a proximal end and a distal end. The inner member defines a longitudinal axis between the proximal end and the distal end. A tip is formed at the distal end of the inner member. A bumper is freely disposed on the inner member. The bumper has a proximal end and a distal end. A seat is defined between the tip and the distal end of the bumper. Additionally, a sheath is disposed about the inner member, the sheath having a proximal end and a distal end. The sheath is movable from a first sheath position substantially covering the seat, and a second sheath position axially offset to expose the seat. The invention also includes a handle in contact with the proximal end of the inner member.

Abstract: An ellipsometer measurement apparatus for determining the thickness of a film applied on a substrate, is described. The apparatus includes a light source emitting an incoming beam, a transmitting optical system conveying the polarized incoming beam to an incidence point on the substrate, and a receiving optical system that has an analyzer and conveys the reflected beam formed at the incidence point to a photodetector device, the polarization direction of the incoming beam and of the analyzer being modified in time relative to one another, and the intensity changes produced thereby being evaluated by way of an evaluation device in order to determine the film thickness.

Abstract: The invention is directed to a delivery system for delivering a medical device. The delivery system includes an inner member having a proximal end and a distal end. The inner member defines a longitudinal axis between the proximal end and the distal end. A tip is formed at the distal end of the inner member. A bumper is freely disposed on the inner member. The bumper has a proximal end and a distal end. A seat is defined between the tip and the distal end of the bumper. Additionally, a sheath is disposed about the inner member, the sheath having a proximal end and a distal end. The sheath is movable from a first sheath position substantially covering the seat, and a second sheath position axially offset to expose the seat. The invention also includes a handle in contact with the proximal end of the inner member.