Abstract: An inhalation device for providing a particularly high pressure for nebulization. The inhalation device can include a housing, a reservoir, a pumping unit adapted to receive the delivery of mechanical energy to the pumping unit, and a nozzle. The pumping unit can also include a hollow cylindrical part and a piston, the cylindrical part having an interior space with a defined first cross section configured to receive an upstream end portion of the piston, wherein the cylindrical part and the piston are linearly moveable relative to one another such as to form a pumping chamber having a variable volume.

Abstract: The device (1) for wetting the eye (2) with a liquid (F) comprises a reservoir (3) for storage of the liquid (F), a dispensing device (4) which is feedable from said reservoir (3) and which is orientable to the eye (2), and a triggering device (5) which activates same. The device (1) comprises a means for sensing (6) of a suitable position of the dispensing device (4) in relation to the eye (2) for wetting. The method for wetting the eye (2) with a liquid (F) comprises the step of continuously detecting the position of a dispensing device (4) designed to withdraw a liquid (F) from a reservoir (3) and to use it for wetting the eye (2). A means for sensing (6) transmits a signal when a suitable position of the dispensing device (4) in relation to the eye (2) for wetting has been sensed.

Abstract: A valve for an inhalation device for generation of an aerosol of a medically active liquid may include: a housing, inside this housing a reservoir for storing medically active liquid, downstream from this reservoir a pumping unit for generation of a pressure connected to a means for the delivery of mechanical energy to said pumping unit, and downstream said pumping unit a nozzle; wherein the pumping unit includes a hollow cylindrical part and a piston, the cylindrical part having an interior space configured to receive an end portion of said piston, wherein said cylindrical part and said piston are linearly moveable relative to one another such as to form a pumping chamber having a variable volume.

Abstract: The invention provides an inhalation device system for the inhalative administration of a medically active liquid in nebulized form, the system comprising an inhalation device and an exchangeable reservoir for holding the medically active liquid, wherein the inhalation device comprises—a housing having a receiving unit, the receiving unit having a connection unit adapted to releasably and fluidically connect to a connection port of the exchangeable reservoir, the receiving unit being adapted to receive and fluidically connect to the exchangeable reservoir; —a nozzle for nebulization of the medically active liquid; and —a pumping unit arranged within the housing and adapted to be fluidically connected to the reservoir (via the connection unit of the receiving unit) and to the nozzle and being adapted to convey (pressurize, pump) the medically active liquid in a downstream direction from the reservoir to the nozzle.

Abstract: The inhalation device for medically active liquids (F) for generation of an aerosol comprises a housing (1), a reservoir (2), a pumping device with a pumping chamber (3), and a nozzle (6), wherein the interior volume of the pumping chamber (3) is changeable by means of linear relative motion of the pumping chamber to the riser pipe (5). Said linear relative motion can be effected by a relative rotation of a rotatable part (1A) which is part of, or connected to, the housing (1) with respect to a second part (1B) of said housing (1), in that said relative rotation can be transferred by means of a gear mechanism into said relative translational motion. A means for the storage of potential energy (7) is provided which is chargeable by means of said relative rotation, and wherein said energy is releasable to said pumping device when released by activation of a release means.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an improved seal construction for an inhalation device having a nebulizing nozzle and a piston which moves relative to a pumping chamber in order to generate pumping pressure and to an inhalation device comprising such seal.

Abstract: Treprostinil or a pharmaceutically acceptable salt or derivative thereof may be used in treating pulmonary hypertension in a subject at risk of developing pulmonary hypertension. The treatment may include administering to the subject a first liquid composition comprising Treprostinil or a pharmaceutically acceptable salt or derivative thereof in a first concentration in aerosolized form for a first treatment period, and administering to said subject a second liquid composition comprising Treprostinil or a pharmaceutically acceptable salt or derivative thereof in a second concentration in aerosolized form for a second treatment period following the first treatment period. The second concentration of the second liquid composition may be higher than the first concentration in the first liquid composition. The liquid compositions are administered using a soft mist inhaler.

Abstract: The invention relates to the field of inhalation methods and inhalation devices for liquids. In particular, the invention relates to an inhalation method using an inhalation device adapted to separately eject at least two liquid compositions each having different properties, and to a method for the generation of an aerosol of at least two medicinal formulations by means of such inhalation device.

Abstract: The invention provides Treprostinil or a pharmaceutically acceptable salt or derivative thereof for use in a method of treatment of pulmonary hypertension in a subject being diagnosed with pulmonary hypertension or being at risk of developing pulmonary hypertension wherein the treatment comprises the steps of i) administering to said subject a first liquid composition comprising Treprostinil or a pharmaceutically acceptable salt or derivative thereof in a first concentration in aerosolized form for a first treatment period, and ii) administering to said subject a second liquid composition comprising Treprostinil or a pharmaceutically acceptable salt or derivative thereof in a second concentration in aerosolized form for a second treatment period following the first treatment period; wherein the second concentration of Treprostinil or a pharmaceutically acceptable salt or derivative thereof in the second liquid composition is higher than the first concentration of Treprostinil or a pharmaceutically acceptable

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a liquid emission mechanism for an inhalation device, as well as a method of emitting a liquid from an inhalation device.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle to be used in such an inhalation device, as well as a method for fabrication of such a nozzle. A nozzle for an inhalation device for nebulizing a liquid into a respirable aerosol has a nozzle body (1) which has a front end (1B) and which comprises at least two ejection channels (2, 2?), each channel (2, 2?) having an channel exit (2A, 2A?), wherein the ejection channels (2, 2?) are arranged such as to eject liquid along respective ejection trajectories which intersect with one another at a collision point. The nozzle is characterized in that at least one recess (3) is provided at the front end (1B) in which the channel exits (2A, 2A?) are positioned.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle to be used in such an inhalation device, as well as a method for fabrication of such a nozzle. A nozzle for an inhalation device for nebulizing a liquid into a respirable aerosol has a nozzle body (1) which has a front end (1B) and which comprises at least two ejection channels (2, 2?), each channel (2, 2?) having an channel exit (2A, 2A?), wherein the ejection channels (2, 2?) are arranged such as to eject liquid along respective ejection trajectories which intersect with one another at a collision point. The nozzle is characterized in that at least one recess (3) is provided at the front end (1B) in which the channel exits (2A, 2A?) are positioned.

Abstract: An inhalation device including a housing; a reservoir for storing a liquid; a pumping unit including a riser pipe; a hollow cylindrical part having an interior space and being linearly moveable on the riser pipe, the pumping chamber fluidically connected with the reservoir; a nozzle connected liquid-tight to a downstream end portion of the riser pipe; wherein the linear relative motion can be effected by a relative rotation around a rotational axis of a rotatable part with respect to a counterpart converting the relative rotation into the linear relative motion by a gear mechanism comprising at least one cam surface having a first section and a second section, a spring for the storage of potential energy, wherein the cam surface has, between the first section and the second section, a third section of constant height upon which no linear relative motion occurs while the counterpart slides along it.

Abstract: The present invention provides an inhalation device system for the inhalative administration of a medically active liquid in nebulized form, the system comprising an inhalation device (20) and an exchangeable reservoir (30) for holding a plurality of doses of the medically active liquid, wherein one dose of the medically active liquid is dispensed from the inhalation device per actuation of the inhalation device system, wherein the inhalation device (20) comprises—a housing (21) having a receiving unit (23), the receiving unit having a connection unit (24) adapted to releasably and fluidically connect to a connection port (31) of the exchangeable reservoir (30), the receiving unit (24) being adapted to receive and fluidically connect to the exchangeable reservoir (30); —a nozzle (25) for the nebulization of the medically active liquid; and—a pumping unit (40) arranged within the housing (21) and adapted to be fluidically connected to the exchangeable reservoir (30) and to the nozzle (25) and being adapted to

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an improved seal construction for an inhalation device having a nebulizing nozzle and a piston which moves relative to a pumping chamber in order to generate pumping pressure and to an inhalation device comprising such seal.

Abstract: The inhalation device for medically active liquids (F) for generation of an aerosol comprises a housing (1), a reservoir (2), a pumping device with a pumping chamber (3), and a nozzle (6), wherein the interior volume of the pumping chamber (3) is changeable by means of linear relative motion of the pumping chamber to the riser pipe (5). Said linear relative motion can be effected by a relative rotation of a rotatable part (1A) which is part of, or connected to, the housing (1) with respect to a second part (1B) of said housing (1), in that said relative rotation can be transferred by means of a gear mechanism into said relative translational motion. A means for the storage of potential energy (7) is provided which is chargeable by means of said relative rotation, and wherein said energy is releasable to said pumping device when released by activation of a release means.

Abstract: The invention provides for device for clamping a fluidic component which is subjected to a fluctuating fluid pressure, said fluidic component having a downstream end, an opposite upstream end and an outer contour, said device comprising a holder, an elastomeric shaped part and a mating part, wherein the elastomeric shaped part comprises at least one compensating surface, and wherein the at least one compensating surface in the assembled state does not contact the mating part or the at least one projection of the mating part.

Abstract: The present invention provides for a method for the treatment of a viral disease, disorder or condition in a subject, the method comprising the step of administering to said subject a medically active liquid in nebulized form by inhalation, wherein the medically active liquid comprises remdesivir or a pharmaceutically acceptable salt thereof and wherein the medically active liquid is administered in nebulized form using an inhalation device.

Abstract: The invention relates to the field of inhalation methods and inhalation devices for liquids. In particular, the invention relates to an inhalation method using an inhalation device adapted to separately eject at least two liquid compositions each having different properties, and to a method for the generation of an aerosol of at least two medicinal formulations by means of such inhalation device.

Abstract: The present invention provides for a method for the treatment of a respiratory disease, disorder or condition, or a viral infection or viral disease, disorder or condition in a subject, the method comprising the step of administering to said subject a medically active liquid in nebulized form by inhalation, wherein the medically active liquid comprises niclosamide or a pharmaceutically acceptable salt thereof and wherein the medically active liquid is administered in nebulized form using an inhalation device.