Patents by Inventor Juergen Wolfrum

Juergen Wolfrum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optical characterization of nucleic acids and oligonucleotides
    Patent number: 6087101
    Abstract: A method for the enzymatic sequencing of DNA is disclosed which uses dideoxythio-nucleotides or dideoxyamino-nucleotides as terminators that are labeled with one or two fluorescent dyes coupled to the terminators either before or after polymerization. The dye labeled DNA fragments are separated in a single lane of a separation system and then the terminal bases of each of the fragments are identified by measuring the fluorescent lifetime of the dye attached to the terminators.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: July 11, 2000
    Inventors: Karl Otto Gruelich, Claus Seidel, Juergen Wolfrum, Manfred Auer, Matthias Gautel, Roger Goody, Siegfried Labeit
  • Application of cuts to biological material
    Patent number: 4748980
    Abstract: In a method for the application of cuts, perforations and/or microlesions to biological material, such as cell agglomerates, individual cells or chromosomes, by means of laser pulses fed into a microscope, the laser pulses are focussed to a cross-section which is limited by diffraction phenomena, and the nth order diffraction maxima (n=1, 2, 3, . . . ) of the laser pulses are used to apply the cuts.
    Type: Grant
    Filed: August 4, 1987
    Date of Patent: June 7, 1988
    Inventors: Christoph Cremer, Thomas Cremer, Karl O. Greulich, Shamci Monajembashi, Juergen Wolfrum