Abstract: Disclosed is a system for screening of traces of illicit substances that may be harmful, such as explosives, radioactive substances, toxics or drugs for example, from very tiny trace concentrations to be detected by way of mass spectrometry being applied to the detached and pre-concentrated particulate matter by the system. Also disclosed is a method in accordance of the system, an arrangement or device as a system element of the system, and a software code on computer readable medium, to control the system and/or acquire data from the system.