Patents by Inventor Juha KLEFSTRÖM

Juha KLEFSTRÖM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230258624
    Abstract: The present disclosure provides ex vivo tumour immune microenvironment model comprising patient-derived explant with a tumour-specific immune cell profile embedded in a matrix comprising nanofibrillar cellulose hydrogel having a concentration in the range of 0.25-1.2% by weight, wherein the nanofibrillar cellulose comprises fibrils and/or fibril bundles having number-average diameter of 200 nm or less.
    Type: Application
    Filed: January 24, 2023
    Publication date: August 17, 2023
    Inventors: Markus NUOPPONEN, Piia MIKKONEN, Jonathan SHEARD, Juha KLEFSTRÖM, Pauliina MUNNE, Rita TURPIN, Aino PEURA, Topi TERVONEN, Maria SALMELA
  • Publication number: 20230151334
    Abstract: The present invention relates to the fields of life sciences and cell and tissue cultures, especially 3D cultures. Specifically, the invention relates to a method of maintaining the presence or activity of a human or mouse estrogen receptor (ER) in a cell of an ex vivo mammary cell or tissue culture or in a cell of other hormone responsive cell or tissue culture. Also, the present invention relates to a method of maintaining a luminal epithelial phenotype and/or cell identity of a mammalian cell in an ex vivo cell or tissue culture. Still, the present invention relates to a 3D matrix or 3D medium comprising the matrix for ex vivo culture, wherein said 3D matrix or 3D medium comprises one or more mammalian cells or tissues embedded in said 3D matrix or 3D medium, and to a system for ex vivo culture, wherein the system comprises mammalian cells or tissues embedded in a 3D matrix or 3D medium comprising said matrix.
    Type: Application
    Filed: April 1, 2021
    Publication date: May 18, 2023
    Inventors: Pauliina MUNNE, Juha KLEFSTRÖM, Lahja MARTIKAINEN, Nonappa NONAPPA, Kia BERTULA, Olli IKKALA