Abstract: A safety syringe with a needle orienting mechanism is capable of securing the needle during normal utilization, disconnecting the needle from orientation after utilization, and drawing the needle back into the safety syringe for safety discarding. The safety syringe has a syringe barrel, a plunger, and a needle assembly. By wedging the retainer buttons of the syringe barrel into the retainer button sockets of the needle assembly, the needle is oriented firmly at its designated location during normal utilization. A drawing mechanism of the plunger is capable of releasing the needle assembly from orientation by rotating the plunger, and drawing the needle assembly back into the syringe barrel. An interlocking mechanism of the needle assembly corresponding to the drawing mechanism is disposed at the rear end of the needle assembly. The drawing mechanism has an anchor shaped reverse hook extended from and formed at the rear end of the piston thereof.