Patents by Inventor Jui-Fang Tsai

Jui-Fang Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8889415
    Abstract: A method for expanding human corneal endothelial cells includes: (a) providing an amniotic membrane with or without amniotic cells, wherein the amniotic membrane has an extracellular matrix; (b) placing onto the amniotic membrane, a sheet of endothelial layer, or a cell suspension including human corneal endothelial stem cells; and (c) culturing the corneal endothelial cells on the amniotic membrane for a duration sufficient for the corneal endothelial stem cells to expand to an appropriate area. The invention also relates to a method for creating a surgical graft for a recipient site of a patient using the method for expanding human corneal endothelial cells, and the surgical graft prepared therefrom.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: November 18, 2014
    Inventor: Ray Jui-Fang Tsai
  • Patent number: 7347876
    Abstract: Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells. The method of creating this graft and the graft itself are simple and effective to reconstruct damaged tissue, a preferred example being corneal tissue. The source of the epithelial stem cells can be a very small explant from healthy autologous and allogeneic tissue biopsy. The amniotic membrane is treated such that its extracellular matrix is maintained, but its cells are killed.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: March 25, 2008
    Inventor: Ray Jui-Fang Tsai
  • Publication number: 20030208266
    Abstract: Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells. The method of creating this graft and the graft itself provide simple and effective means to reconstruct damaged tissue, a preferred example being corneal tissue. The source of the epithelial stem cells can be a very small explant from healthy autologous and allogeneic tissue biopsy. The amniotic membrane is treated such that its extracellular matrix is maintained, but its cells are killed.
    Type: Application
    Filed: December 13, 2002
    Publication date: November 6, 2003
    Inventor: Ray Jui-Fang Tsai
  • Patent number: 6533813
    Abstract: The present invention is to provide an intraocular lens that may accommodate automatically, including a central optic having an anterior optic connected with the stroke cylinder, a posterior optic connected with the outer core which is connected with the stroke cylinder, thereby enclosing the central optic in an inner periphery. Thus, by change of the inclined angle of the user, or by variation of the external magnetic field, the push force that is exerted on the central optic of the intraocular lens may be regulated, so as to actively control the position of the central optic of the intraocular lens, so that the user may actively control and regulate the refractive power of the eyeball that is implanted with the intraocular lens.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: March 18, 2003
    Inventors: Chwen Yih Lin, Ray Jui-Fang Tsai
  • Publication number: 20030050695
    Abstract: The present invention is to provide an intraocular lens that may accommodate automatically, including a central optic having an anterior optic connected with the stroke cylinder, a posterior optic connected with the outer core which is connected with the stroke cylinder, thereby enclosing the central optic in an inner periphery. Thus, by change of the inclined angle of the user, or by variation of the external magnetic field, the push force that is exerted on the central optic of the intraocular lens may be regulated, so as to actively control the position of the central optic of the intraocular lens, so that the user may actively control and regulate the refractive power of the eyeball that is implanted with the intraocular lens.
    Type: Application
    Filed: September 7, 2001
    Publication date: March 13, 2003
    Inventors: Chwen Yih Lin, Ray Jui-Fang Tsai
  • Publication number: 20010053917
    Abstract: A microkeratome and method for performing lamellar keratoplasty is disclosed. The microkeratome consist of a cutting blade with a curved sharp edge. In surgery, a programmed curved guide rail is utilized to guide the cutting blade to move along a programmed curved path so that achieve a near spherical curved cutting pathway so as to cut the cornea in near its original un-flattened normal position. The microkeratome for performing lamellar keratoplasty includes a vacuum suction ring with guide rails, a cutting head assembly with a cambered cutting blade and curved front press and curved rear press. By controlling the internal components of the tool so that the vacuum suction ring can fix an eyeball.
    Type: Application
    Filed: June 15, 2001
    Publication date: December 20, 2001
    Inventors: Chwen-Yih Lin, Jui-Fang Tsai