Patents by Inventor Jui-Hung Shien

Jui-Hung Shien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A FUSION PROTEON OF STROMAL CELL-DERIVED FACTOR-1 (SDF-1) AND INTERLEUKIN-2 (IL-2) AND APPLICATIONS THEREOF
    Publication number: 20230265150
    Abstract: The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.
    Type: Application
    Filed: March 17, 2023
    Publication date: August 24, 2023
    Applicant: NATIONAL CHUNG HSING UNIVERSITY
    Inventors: Shiow-Her CHIOU, Kuan-Chih CHOW, Jui-Hung SHIEN, Yi-Hsin FAN, Pei-Hua LIN, Pei-Shan WU
  • CHEMOKINE-CYTOKINE FUSION PROTEINS AND THEIR APPLICATIONS
    Publication number: 20190270788
    Abstract: The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.
    Type: Application
    Filed: May 17, 2019
    Publication date: September 5, 2019
    Applicant: NATIONAL CHUNG HSING UNIVERSITY
    Inventors: Shiow-Her Chiou, Kuan-Chih Chow, Jui-Hung Shien, Yi-Hsin Fan, Pei-Hua Lin, Pei-Shan Wu
  • Chemokine-cytokine fusion proteins of SDF-1 and CD40L
    Patent number: 10336801
    Abstract: The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: July 2, 2019
    Assignee: NATIONAL CHUNG HSING UNIVERSITY
    Inventors: Shiow-Her Chiou, Kuan-Chih Chow, Jui-Hung Shien, Yi-Hsin Fan, Pei-Hua Lin, Pei-Shan Wu
  • CHEMOKINE-CYTOKINE FUSION PROTEINS AND THEIR APPLICATIONS
    Publication number: 20170327554
    Abstract: The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.
    Type: Application
    Filed: July 25, 2017
    Publication date: November 16, 2017
    Applicant: NATIONAL CHUNG HSING UNIVERSITY
    Inventors: Shiow-Her CHIOU, Kuan-Chih CHOW, Jui-Hung SHIEN, Yi-Hsin FAN, Pei-Hua LIN, Pei-Shan WU
  • Subunit vaccine of in veterinary uses
    Patent number: 8084043
    Abstract: The present invention declaims the use of Pasteurella lipoprotein E (PlpE) as a subunit vaccine and the use of vaccines containing PlpE to protect animals from diseases caused by P. multocida. The results of vaccination and challenge experiments showed that mice and chickens immunized with PlpE were completely protected animals from challenge infection with 101-103 LD50 of P. multocida and no adverse effect was observed.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: December 27, 2011
    Assignee: National Chung-Hseng University
    Inventors: Poa-Chun Chang, Jin-Ru Wu, Jui-Hung Shien, Happy K. Shieh
  • Subunit vaccine of pasteurella multocida in veterinary uses
    Publication number: 20090246229
    Abstract: The present invention declaims the use of Pasteurella lipoprotein E (PlpE) as a subunit vaccine and the use of vaccines containing PlpE to protect animals from diseases caused by P. multocida. The results of vaccination and challenge experiments showed that mice and chickens immunized with PlpE were completely protected animals from challenge infection with 101-103 LD50 of P. multocida and no adverse effect was observed.
    Type: Application
    Filed: March 4, 2008
    Publication date: October 1, 2009
    Inventors: Poa-Chun Chang, Jin-Ru Wu, Jui-Hung Shien, Happy K. Shieh