Patents by Inventor Jui-Yang Lai

Jui-Yang Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11166916
    Abstract: Disclosed herein is a carbon quantum dot produced by the step of subjecting dopamine and spermine to a pyrolysis treatment at 250° C. Also disclosed herein is use of the carbon quantum dot for treating a bacterial infection, and for inhibiting bacterial growth and biofilm formation.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: November 9, 2021
    Assignee: Chang Gung University
    Inventors: Jui-Yang Lai, Chih-Ching Huang, Hong-Jyuan Jian
  • Publication number: 20210177763
    Abstract: Disclosed herein is a carbon quantum dot produced by the step of subjecting dopamine and spermine to a pyrolysis treatment at 250° C. Also disclosed herein is use of the carbon quantum dot for treating a bacterial infection, and for inhibiting bacterial growth and biofilm formation.
    Type: Application
    Filed: May 29, 2020
    Publication date: June 17, 2021
    Inventors: Jui-Yang Lai, Chih-Ching Huang, Hong-Jyuan Jian
  • Patent number: 10966955
    Abstract: Disclosed herein is an ocular drug delivery system, comprising a positively charged chitosan-modified hydrogel, a secretory phospholipase A2 (sPLA2) hydrolysable liposome encapsulating an anti-inflammatory drug and having a negative surface charge, a first thiolated hyaluronic acid (HA-SH) nanoparticle encapsulating a wound-healing drug and having a negative surface charge, and a second HA-SH nanoparticle encapsulating a transforming growth factor-? inhibitor and having a negative surface charge. The sPLA2 hydrolysable liposome and the first and second HA-SH nanoparticles are attached to the positively charged chitosan-modified hydrogel by electrostatic attraction. Uses of the system are also disclosed.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: April 6, 2021
    Assignee: Chang Gung University
    Inventors: Jui-Yang Lai, Li-Jyuan Luo, Chung-Cheng Lo, Duc Dung Nguyen
  • Publication number: 20210059980
    Abstract: Disclosed herein is an ocular drug delivery system, comprising a positively charged chitosan-modified hydrogel, a secretory phospholipase A2 (sPLA2) hydrolysable liposome encapsulating an anti-inflammatory drug and having a negative surface charge, a first thiolated hyaluronic acid (HA-SH) nanoparticle encapsulating a wound-healing drug and having a negative surface charge, and a second HA-SH nanoparticle encapsulating a transforming growth factor-? inhibitor and having a negative surface charge. The sPLA2 hydrolysable liposome and the first and second HA-SH nanoparticles are attached to the positively charged chitosan-modified hydrogel by electrostatic attraction. Uses of the system are also disclosed.
    Type: Application
    Filed: March 13, 2020
    Publication date: March 4, 2021
    Inventors: Jui-Yang Lai, Li-Jyuan Luo, Chung-Cheng Lo, Duc Dung Nguyen
  • Patent number: 9815959
    Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: November 14, 2017
    Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.
    Inventors: Jui-Yang Lai, Kao-Yuan Chang, Zih-Han Hong, Po-Cheng Lin, Ming-Hsi Chuang
  • Publication number: 20150274923
    Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.
    Type: Application
    Filed: February 26, 2015
    Publication date: October 1, 2015
    Inventors: Jui-Yang Lai, Kao-Yuan Chang, Zih-Han Hong, Po-Cheng Lin, Ming-Hsi Chuang
  • Publication number: 20150238534
    Abstract: A hollow particle is provided. The hollow particle of the invention comprises (a) a hollow microparticle, (b) a plural of linking molecules binding the surface of the microparticle, (c) a polypeptide binding the linking molecule, and (d) a target molecule binding the linking molecule. The hollow microparticle of the invention can deliver more cells and provides a higher rate of cell transplantation by the hollow structures, polypeptides and target molecules. The present invention also provides a manufacture of the hollow microparticle and a cell carrier.
    Type: Application
    Filed: February 26, 2015
    Publication date: August 27, 2015
    Inventors: Jui-Yang Lai, Li-Jyuan Luo, Zih-Han Hong, Kao-Yuan Chang, Po-Cheng Lin, Ming-Hsi Chuang
  • Publication number: 20130302885
    Abstract: A method of forming cell spheroids cultured in a serum-free manner on nanoscale coatings of hyaluronic acid with high molecular weight is disclosed. Corneal stromal cells are cultured on the hyaluronic acid coatings with nanotopography in the serum-free manner. Experimental results show that the cells cultured on the hyaluronic acid coatings (1.1-1.7 nm) increase cell-cell interaction, and when the cells form three-dimensional spheroids, they have higher biological synthetic capabilities and can secret more extracellular matrix, which has potential applications in corneal stromal tissue reconstruction.
    Type: Application
    Filed: May 14, 2012
    Publication date: November 14, 2013
    Inventors: Jui-Yang Lai, I-Hao Tu, Ting-Chun Yu
  • Publication number: 20120315265
    Abstract: Disclosed herein are a hydrogel-forming polymer and a process of making the same. Also disclosed are a sustained-release pharmaceutical composition that contains a therapeutic agent and the aforesaid hydrogel-forming polymer, and a method for treating or preventing an ophthalmic disorder, which includes intraocularly administering into an eye of a mammal in need of such treatment a sustained-release pharmaceutical composition that contains an ophthalmic drug and the aforesaid hydrogel-forming polymer.
    Type: Application
    Filed: January 20, 2012
    Publication date: December 13, 2012
    Applicant: CHANG GUNG UNIVERSITY
    Inventors: Jui-Yang Lai, Ai-Ching Hsieh, Pei-Lin Lu
  • Publication number: 20090263465
    Abstract: A biopolymer-bioengineered human corneal endothelial cell (HCEC) sheet construct for reconstructing corneal endothelium in a patient is recited. The construct includes a biopolymer carrier which is bioresorable and deformable; and a bioengineered cell sheet containing a monolayer of interconnected HCECs with substantially uniform orientation. The bioengineered cell sheet is attached to a surface of the biopolymer carrier with apical surfaces of the HCECs facing said carrier.
    Type: Application
    Filed: June 30, 2009
    Publication date: October 22, 2009
    Applicant: National Tsing Hua University
    Inventors: Ging-Ho HSIUE, Jui-Yang Lai
  • Publication number: 20080050423
    Abstract: The present invention discloses a biopolymer-bioengineered human corneal endothelial cell (HCEC) sheet construct for reconstructing corneal endothelium in a patient. The construct includes a biopolymer carrier which is bioresorable and deformable; and a bioengineered cell sheet comprising a monolayer of interconnected HCECs with substantially uniform orientation, wherein the bioengineered cell sheet is attached to a surface of the carrier with apical surfaces of the HCECs facing said carrier.
    Type: Application
    Filed: August 23, 2006
    Publication date: February 28, 2008
    Applicant: National Tsing Hua University
    Inventors: Ging-Ho Hsiue, Jui-Yang Lai
  • Publication number: 20040221130
    Abstract: A method for accessing a non-volatile memory by both PC and X-BOX is disclosed. The method includes the following steps: initializing a memory controller, preferably with a USB interface, for accessing the non-volatile memory; generating the first logical-to-physical address mapping table for mapping the first portion of the non-volatile memory; configuring the controller; monitoring the occurrence of an event; analyzing the starting logic address specified in a token packet sent from the host to the controller in response to the event; and generating the second logical-to-physical address mapping table for mapping the second portion of the non-volatile memory when its starting logic address is absent in the first logical-to-physical address mapping table.
    Type: Application
    Filed: April 30, 2004
    Publication date: November 4, 2004
    Inventors: Jui Yang Lai, Hsin Ching Yin