Patents by Inventor Juichi Awaya
Juichi Awaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5464818Abstract: There are described a novel protein derived from Clostridium perfringens FERM BP-4584 method of obtaining the same and use thereof as an effective ingredient for treating wounds and ulcers. The protein has a molecular weight of 420,000.+-.40,000 by a GPC, isoelectric point of 4.8, and consists of a single subunit having a molecular weight of 130,000.+-.20,000 by a SDS-polyacrylamide gel electrophoresis, and shows cell growth-stimulating activity as well as macrophage chemotactic action. The protein can be extracted and separated by conventional techniques for obtaining a protein from general microorganisms, by taking an inhibition of decomposition into consideration, since the protein is not so stable.Type: GrantFiled: December 29, 1994Date of Patent: November 7, 1995Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Tadashi Yamaguchi, Hiroshi Uesaka, Kazuo Watanabe, Juichi Awaya
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Patent number: 5340806Abstract: A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition. The treatment of hepatitis with compositions containing this germanium derivative.Type: GrantFiled: January 7, 1993Date of Patent: August 23, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Juichi Awaya, Akio Kojima, Hideaki Ninomiya, Yoshiro Ishiwata, Masahiro Nakajima
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Patent number: 5336688Abstract: A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition.Type: GrantFiled: January 25, 1993Date of Patent: August 9, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Juichi Awaya, Akio Kojima, Hideako Ninomiya, Yoshiro Ishiwata, Masahiro Nakajima
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Patent number: 5290679Abstract: Even when the specimen contains human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes, the present invention enables the total quantity of elastase in that specimen to be precisely detected. The inhibitor is added to free elastase to convert it into an elastase-inhibitor complex, whereby the quantity of elastase can be measured by immunoassay as the total amount including the previously existing elastase-inhibitor complex. It is possible to precisely measure the total amount of elastase in mucus collected from the cervical canal of a pregnant woman, sputum or a rinsed solution of bronchovesicular lavage in which free elastase is mixed with an elastase-inhibitor complex.Type: GrantFiled: June 15, 1992Date of Patent: March 1, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Toshihiko Terao, Naohiro Kanayama, Akihiro Morioka, Yoshika Yasuda, Masami Kamiya, Juichi Awaya, Masayasu Kurono, Kiichi Sawai
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Patent number: 4889715Abstract: A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition.Type: GrantFiled: July 25, 1988Date of Patent: December 26, 1989Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Juichi Awaya, Akio Kojima, Hideaki Ninomiya
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Patent number: 4324728Abstract: The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: ##STR1## in which (a) R is H and R' is OH (nanaomycin A),(b) R is H and R' is NH.sub.2 (nanaomycin C),(c) R is COCH.sub.3 and R' is OH (acetylnanaomycin A), and(d) R is H and R' is OCH.sub.3 (nanaomycin A methyl ester).Nanaomycin A is a new compound of quinone type and its acute toxicity (LD.sub.50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A.Type: GrantFiled: June 11, 1979Date of Patent: April 13, 1982Assignee: The Kitasato InstituteInventors: Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata
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Patent number: 4308210Abstract: The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD.sub.50, intra-penetrial injection) in mice of this compound is 169 mg/Kg.Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom.Type: GrantFiled: May 25, 1979Date of Patent: December 29, 1981Assignee: The Kitasato InstituteInventors: Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata
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Patent number: 4226879Abstract: The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD.sub.50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient.Type: GrantFiled: September 1, 1978Date of Patent: October 7, 1980Assignees: Kyowa Hakko Kogyo Kabushiki Kaisha, The Kitasato InstituteInventors: Satoshi Omura, Chiaki Kitao, Akira Nakagawa, Haruo Tanaka, Juichi Awaya, Ruiko Oiwa
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Patent number: 4199514Abstract: A novel compound frenolicin B of the formula: ##STR1## is prepared by cultivating a microorganism belonging to genus Streptomyces, e.g. Streptomyces roseofulvus AM-3867, in a culture medium and isolating the compound formed and accumulated in the medium from the cultured product. Said frenolicin B is useful as an antibiotic.Type: GrantFiled: January 25, 1979Date of Patent: April 22, 1980Assignee: The Kitasato InstituteInventors: Satoshi Omura, Yuzuru Iwai, Juichi Awaya, Yoko Takahashi, Ruiko Oiwa
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Patent number: 4196266Abstract: The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: ##STR1## in which (a) R is H and R' is OH (nanaomycin A),(b) R is H and R' is NH.sub.2 (nanaomycin C),(c) R is COCH.sub.3 and R' is CH (acetylnanaomycin A), and(d) R is H and R' is OCH.sub.3 (nanaomycin A methyl ester).Nanaomycin A is a new compound of quinone type and its acute toxicity (LD.sub.50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A.Type: GrantFiled: December 7, 1977Date of Patent: April 1, 1980Assignee: The Kitasato Institute (Kitasato Kenkyuosho)Inventors: Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata
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Patent number: 4194064Abstract: The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD.sub.50, intra-penetrial injection) in mice of this compound is 169 mg/kg. Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom.Type: GrantFiled: December 7, 1977Date of Patent: March 18, 1980Assignee: The Kitasato Institute (Kitasato Kenkyusho)Inventors: Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata
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Patent number: 3995028Abstract: The present invention relates to a new antibiotic designated as OS-3256-B. OS-3256-B exhibits excellent inhibitory activities against animal tumors such as leukemia L-1210, Sarcoma-180 and Hela cells and gram-positive bacteria and is classified into the diazocompounds group. However, chromatographic analysis, Rf value and other experimental data reveal that OS-3256-B is a new compound of the type of azaamino acid derivatives. The present invention also provides a process for producing OS-3256-B by fermentation, in which OS-3256-B is produced by culturing a microorganism belonging to Streptomyces candidus var. azaticus in a culture medium conventionally used for culturing Streptomyces strain microorganisms.Type: GrantFiled: August 21, 1975Date of Patent: November 30, 1976Assignee: The Kitasato InstituteInventors: Satoshi Omura, Iwao Umezawa, Keiki Satoh, Juichi Awaya, Kanki Komiyama, Ruiko Oiwa
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Patent number: 3974273Abstract: This invention relates to a new compound NA-337 and a process for producing the same by fermentation. NA-337 is positive in Dragendorff's reagent. NA-337 is confirmed to be a new compound having a fat-clearing activity. This compound is produced by fermentation, in which an NA-337-producing strain is cultured aerobically in a medium and the accumulated NA-337 is recovered from the cultured matters.Type: GrantFiled: March 14, 1975Date of Patent: August 10, 1976Assignee: The Kitasato InstituteInventors: Satoshi Omura, Haruo Tanaka, Juichi Awaya, Yaeko Konda, Yoshitsugu Narimatsu, Masayuki Onda
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Patent number: 3956276Abstract: The antifungal antibiotic substance "F-1028" having the following formula, ##EQU1## or an acid salt thereof, a process for the production of the same by fermentation, and a fungicidal composition useful for agricultural and horticultural use.Type: GrantFiled: July 17, 1972Date of Patent: May 11, 1976Assignees: Nihon Tokushu Moyaku Seizo Kabushiki Kaisha, The Kiyasato InstituteInventors: Toju Hata, Satoshi Omura, Michiko Katagiri, Juichi Awaya, Shimpei Kuyama, Shizuo Higashikawa, Kazuomi Yasui, Haruko Terada
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Patent number: 3956487Abstract: The antifungal antibiotic substance "F-1028" having the following formula, ##EQU1## or an acid salt thereof, a process for the production of the same by fermentation, and a fungicidal composition useful for agricultural and horticultural use.Type: GrantFiled: March 20, 1974Date of Patent: May 11, 1976Assignees: Nihon Tokushu Noyaku Seizo Kabushiki Kaisha, The Kitasato InstituteInventors: Toju Hata, Satoshi Omura, Michiko Katagiri, Juichi Awaya, Shimpei Kuyama, Shizuo Higashikawa, Kazuomi Yasui, Haruko Terada