Abstract: Particles are exhaled in the breath of animals. The nature and amounts of the particles can be indicative of certain medical conditions. They can therefore be collected, sorted according to size or mass and used in the diagnosis of one or more medical conditions. The invention provides a method and system for collecting and sorting exhaled particles and a method for diagnosis using said exhaled particles.

Abstract: The present invention relates to a method for inducing and/or promoting osteogenic differentiation using extracellular vesicles and the use thereof.

Abstract: An implant that includes titanium and has one or more surfaces which can be applied in or on a bone growth area. One or more of the surfaces are arranged with a depot for bone-growth-initiating or bone-growth-stimulating substance, in which the depot is formed by a pore arrangement in a relatively thick oxide layer on the titanium. The substance is acted on, for a considerable period of time, by one or more release functions for the substance which permit a controlled or optimized release of substance to the surrounding tissue or bone growth area.

Abstract: A method for the formation of a surface coating of an ion substituted calcium phosphate on a substrate, the coating itself and the use of the coating.

Abstract: A layer is arranged on an implant for bone or tissue structure. The layer constitutes a boundary or barrier between the actual or unoxidized body of the implant and the structure for the purpose of increasing retention and has, in this context, a substantial thickness. The layer is designed with a channel network which gives the layer a substantial porosity. The channel network is designed with mouths which face towards the structure and whose respective cross-sectional diameters, at the surface of the layer facing towards the structure, are substantially less than the respective extents of the channels in and down into the layer as seen from the said surface.

Abstract: Particles are exhaled in the breath of animals. The nature and amounts of the particles can be indicative of certain medical conditions. They can therefore be collected, sorted according to size or mass and used in the diagnosis of one or more medical conditions. The invention provides a method and system for collecting and sorting exhaled particles and a method for diagnosis using said exhaled particles.

Abstract: A layer is arranged on an implant for bone or tissue structure. The layer constitutes a boundary or barrier between the actual or unoxidized body of the implant and the structure for the purpose of increasing retention and has, in this context, a substantial thickness. The layer is designed with a channel network which gives the layer a substantial porosity. The channel network is designed with mouths which face towards the structure and whose respective cross-sectional diameters, at the surface of the layer facing towards the structure, are substantially less than the respective extents of the channels in and down into the layer as seen from the said surface.

Abstract: A layer (2??) is arranged on an implant (1?) for bone or tissue structure (5). The layer constitutes a boundary or a barrier between the actual or unoxidized body of the implant (1?) and the structure for the purpose of increasing retention and has in this context, a substantial thickness (T?). The layer (2??) is designed with a channel network (6) which gives the layer a substantial porosity. The channel network (6) is designed with mouths (3?,4?) which face towards the structure (5) and whose respective cross-sectional diameters (D), at the surface (2a?) of the layer (2??) facing towards the structure (5), are substantially less than the respective extents (e.g., H) of the channels in and down into the layer (2??) as seen from the said surface (2a?).

Abstract: An implant comprises titanium and has one or more surfaces which can be applied in or on a bone growth area. One or more of the surfaces are arranged with a depot for bone-growth-initiating or bone-growth-stimulating substance, in which the depot is formed by a pore arrangement in a relatively thick oxide layer on the titanium. The substance is acted on, for a considerable period of time, by one or more release functions for the substance which permit a controlled or optimized release of substance to the surrounding tissue or bone growth area.

Abstract: An implant comprises or consists of titanium and has one or more surfaces which can be applied in or on a bone growth area. One or more of the said surfaces are arranged with a depot for bone-growth-initiating or bone-growth-stimulating substance, which depot is formed by a pore arrangement in a relatively thick oxide layer on the titanium. The substance is acted on, for a considerable period of time, by one or more release functions for the substance which permit a controlled or optimized release of substance to the surrounding tissue or bone growth area.

Abstract: A method of analyzing the spatial distribution of at least one chemical substance retained by a biological matter comprises the steps of (a) supplying a sample of said biological matter as a specimen surface; (b) producing at least one imprint of said specimen surface on at least one corresponding separate substrate surface, said at least one chemical substance being transferred to the same with retained lateral distribution thereon; (c) subjecting said at least one imprint to imaging mass spectrometry, at least one signal from at least two points being produced, the magnitude of said at least one signal being dependent on the amount of said at least one chemical substance laterally present on said substrate surface; (d) recording said at least one signal from said at least two points; and (e) determining said spatial distribution of said at least one chemical substance from said at least one image of said at least one imprint.

Abstract: A method for preparing implant surfaces using gas discharge plasma including conveying the implants to a vacuum chamber. The implants are treated with an inert gas plasma to remove existing surface contamination and oxide layers from the implant surfaces. The implants are treated with an oxidizing plasma or by means of thermal oxidation to reoxidizing the implant surfaces. The implant treatment steps are carried out in a closed space, including a controlled atmosphere and produce a highly accurate and reproducible microstructure, composition, purity, and sterility in the implants.

Abstract: The invention relates to a method of packaging artificial implants in a sterile and contamination-free manner, comprising applying the implant inside a closable capsule made of the same material as the implant, thereafter enclosing the capsule in a hermetically sealable outer casing and sterilizing the package thus produced, and also to a package for performing the method.