Patents by Inventor Jules Chen

Jules Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12077830
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: September 3, 2024
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • Publication number: 20230279513
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: January 13, 2023
    Publication date: September 7, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • Publication number: 20230235412
    Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.
    Type: Application
    Filed: November 14, 2022
    Publication date: July 27, 2023
    Inventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
  • Patent number: 11555223
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: January 17, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • Patent number: 11499199
    Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: November 15, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
  • Publication number: 20210095352
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: October 5, 2020
    Publication date: April 1, 2021
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • Patent number: 10801078
    Abstract: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: October 13, 2020
    Assignee: Quest Diagnostics Infectious Disease, Inc.
    Inventors: Fan Chen, Lilly I. Kong, Jules Chen, Mehrdad Jannatipour
  • Patent number: 10793924
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: October 6, 2020
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • Publication number: 20200123596
    Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.
    Type: Application
    Filed: October 29, 2019
    Publication date: April 23, 2020
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
  • Publication number: 20190382826
    Abstract: The present disclosure provides methods for determining whether a patient exhibiting pertussis-like symptoms will benefit from treatment, with therapeutic agents that inhibit Bordetella holmesii. These methods are based on detecting Bordetella pertussis, Bordetella parapertussis, and Bordetella holmesii in a biological sample by assaying for the presence of the IS481, IS 1001, and hIS1001 target repeat elements, respectively. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: March 23, 2017
    Publication date: December 19, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Jules Chen, Michelle Tabb
  • Patent number: 10465252
    Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: November 5, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
  • Publication number: 20190211408
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: June 2, 2017
    Publication date: July 11, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • Patent number: 10260113
    Abstract: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: April 16, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Jules Chen, Lilly I. Kong, Ming-Chou Lee, Fan Chen, Michelle M. Tabb, Michael Aye
  • Publication number: 20180044742
    Abstract: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.
    Type: Application
    Filed: August 22, 2017
    Publication date: February 15, 2018
    Applicant: Focus Diagnostics, Inc.
    Inventors: Fan Chen, Lilly I. Kong, Jules Chen, Mehrdad Jannatipour
  • Patent number: 9745638
    Abstract: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: August 29, 2017
    Assignee: Focus Diagnostics, Inc.
    Inventors: Fan Chen, Lilly I. Kong, Jules Chen, Mehrdad Jannatipour
  • Patent number: 9194006
    Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: November 24, 2015
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Jules Chen, Michelle M. Tabb, Michael Aye, Emberlee Eleazar
  • Publication number: 20140349275
    Abstract: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.
    Type: Application
    Filed: April 29, 2014
    Publication date: November 27, 2014
    Applicant: Focus Diagnostics, Inc.
    Inventors: Fan Chen, Lilly I. Kong, Jules Chen, Mehrdad Jannatipour
  • Patent number: 8748092
    Abstract: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: June 10, 2014
    Assignee: Focus Diagnostics, Inc.
    Inventors: Fan Chen, Lilly I. Kong, Jules Chen, Mehrdad Jannatipour
  • Patent number: 8354230
    Abstract: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: January 15, 2013
    Assignee: Quest Diagnostics Investments Inc.
    Inventors: Jules Chen, Lilly I. Kong, Ming-Chou Lee, Fan Chen, Michelle M. Tabb, Michael Aye
  • Publication number: 20110143349
    Abstract: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.
    Type: Application
    Filed: January 12, 2011
    Publication date: June 16, 2011
    Inventors: Fan Chen, Lilly I. Kong, Jules Chen, Mehrdad Jannatipour