Abstract: The present invention provides novel compounds such as certain aryloxy indanamines which are useful as anti-depressants and as inhibitors of synaptic norepinephrine and serotonin uptake. The present invention also provides an improvement in the treatment of depression which comprises inhibiting synaptic serotonin and epinepherine uptake.

Abstract: Certain triphenylpiperidines reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.

Abstract: Diarylalkyl piperidines of formula (1) ##STR1## reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.

Abstract: The present invention provides novel aryloxy indanamines which are useful as anti-depressants and as inhibitors of synaptic norepinephrine and serotonin uptake.

Abstract: The present invention is directed to a new class of arylalkoxyphenoxy-imidazoline compounds and their use for the treatment of depression, anxiety, hypertension, and migraine headaches.

Abstract: The present invention is directed to a new class of arylalkoxyphenoxy-imidazoline compounds and their use for the treatment of depression, anxiety, hypertension, and migraine headaches.

Abstract: Novel bis-dibenzoazepine compounds useful in the treatment of malaria and drug-resistant malaria.

Abstract: The present invention provides novel aryloxy indanamines of the formula ##STR1## wherein n, p and q are each independently 0, 1 or 2,Y and X are each independently lower alkyl, lower alkoxy, hydroxy, CF.sub.3, halogeno or when p or q are 2 and each of the Y or each of the X groups are on adjacent aryl carbon atoms, both of the X or both of the Y groups can be taken together to form a methylenedioxy moiety,R.sub.1 and R.sub.2 are each independently hydrogen, lower alkyl, aralkyl, or R.sub.1 and R.sub.2 taken together with the nitrogen to which they are attached are pyrrolidino, morpholino, piperidino, piperazino, or 4-methylpiperazino,or an acid addition salt thereof, which are useful as antidepressants and as inhibitors of synaptic norepinephrine and serotonin uptake.

Abstract: Drug-resistant protozoal infection, particularly, drug-resistant malarial infection in humans, can be effectively treated with standard antiprotozoal agents if administered in conjunction with a phenoxyamino-substituted benzocycloalkane derivative.

Abstract: The present invention is directed to a new class of phenoxy-heterocyclic compounds and to their use as anti-depressants and as anxiolytics.

Abstract: Derivatives of 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, such as trans-3,4,4a,5,6,11b-hexahydro-10-methoxy-2H-[1]benzoxepino[5,4-b]-1,4-oxa zine, are prepared by acylating a trans-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol, cyclizing the resulting chloroacetamido alcohol, reducing the 1,4-oxazine-3(4H)-one so obtained, acylating the resulting 2H-[1]-benzoxepino[5,4-b]-1,4-oxazine, and reducing the N-acryl-2H-[1]benzoxepino[5,4-b]-1,4-oxazine so obtained. The novel compounds disclosed herein possess useful antihypertensive properties.

Abstract: The compounds are 11-aminoalkylmorphanthridin-11-ols which are useful as antidepressant agents. The compounds disclosed are 11-(3-dimethylaminopropyl)morphanthridin-11-ol and 2-chloro-11-(3-dimethylaminopropyl)-5,6-dihydromorphanthridin-11-ol.

Abstract: The inventive method comprises administering a morphanthridine to an animal to effect the lowering of inflammation. Representative of the compounds that can be used in the method are trans-5-acetyl-2-bromo-5,6-dihydro-11-(3-dimethylaminopropylidene)-morphan thridine and trans-2-bromo-11-(3-dimethylaminopropylidene)-5,6-dihydro-5-propionylmorph anthridine.

Abstract: Pure cis or trans-6-substituted-11-aminoalkylidenemorphanthridines are prepared by treating the corresponding cis or trans-5,6-dihydromorphanthridines with oxygen in the presence of a platinum on carbon catalyst. Among the compounds prepared are:Cis-2-Chloro-11-(3-dimethylaminopropylidene)-6-phenylmorphanthridine, andTrans-2-Chloro-11-(3-dimethylaminopropylidene)-6-methylmorphanthridine.The compounds are useful as antihypertensive and anti-Parkinson agents.

Abstract: Pure cis and trans-6-substituted-11-aminoalkylidene-5,6-dihydromorphanthridines are prepared by treating the morphanthridines unsubstituted in the 6-position with a Grignard reagent in a suitable solvent such as tetrahydrofuran. Among the compounds disclosed are:Cis-2-Chloro-11-(3-dimethylaminopropylidene)-6-phenyl-5,6-dihydromorphanthr idine, andTrans-2-Chloro-11-(3-dimethylaminopropylidene)-6-methyl-5,6-dihydromorphant hridine.The compounds are useful as antihypertensive and anti-Parkinson agents.