Patents by Inventor Jules S. Jacob
Jules S. Jacob has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230365689Abstract: This invention relates to therapeutic, diagnostic and/or prophylactic formulations and dosages and dosing regimens of anti-CD3 antibodies, as well as to methods for using such formulations and dosages and dosing regimens.Type: ApplicationFiled: May 15, 2023Publication date: November 16, 2023Inventors: Jules S. JACOB, Vaseem A. PALEJWALA, Kunwar SHAILUBHAI
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Publication number: 20220332822Abstract: This invention provides methods of subcutaneous administration of anti-CD3 monoclonal antibodies (mAbs) either alone or in combination with monoclonal antibodies, that recognize the Interleukin-6 (IL-6) and IL-6 receptor (IL-6R) complex for the treatment, prevention or alleviating a symptom of a disease.Type: ApplicationFiled: April 18, 2022Publication date: October 20, 2022Inventors: Kunwar SHAILUBHAI, Vaseem A. PALEJWALA, Jules S. JACOB
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Publication number: 20210284743Abstract: The present disclosure provides compositions and methods for the treatment of coronavirus infections, such as SAR-CoV, SARS-CoV-2, and MERS-CoV. The compositions include antibodies targeting the IL-6 receptor complex, antibodies targeting CD3, dactinomycin, and combinations thereof. The methods of treatment include administration of antibodies and combination therapies to reduce or eliminate symptoms associated with coronavirus infection or pulmonary inflammatory disease.Type: ApplicationFiled: March 10, 2021Publication date: September 16, 2021Inventors: Kunwar SHAILUBHAI, Gabriele CERRONE, Vaseem A. PALEJWALA, Jules S. JACOB
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Publication number: 20100216751Abstract: The present application discloses and claims liquid pharmaceutical compositions comprising bevirimat dimeglumine as a drug substance, methods of treatment comprising administering such compositions to a subject in need thereof, and the use of such compositions in the manufacture of medicaments.Type: ApplicationFiled: March 25, 2010Publication date: August 26, 2010Applicant: Myriad Pharmaceuticals, Inc.Inventors: Jules S. Jacob, John Richards, John G. Augustine, Jaqueline S. Milea
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Publication number: 20100172998Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.Type: ApplicationFiled: July 10, 2008Publication date: July 8, 2010Inventors: Edith Mathiowitz, Donald E. Chickering, III, Yong S. Jong, Jules S. Jacob
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Patent number: 7029700Abstract: A process is provided for making dry, micronized particles of an agent, such as a drug. The method includes (a) dissolving a macromolecular material, preferably a polymer, in an effective amount of a solvent, to form a solution; (b) dissolving or dispersing the agent in the solution to form a mixture; (c) freezing the mixture; and (d) drying by vacuum the mixture to form solid particles of the agent dispersed in solid macromolecular material. The micronization in this process occurs directly in a macromolecular matrix and hardening of the particles of agent by solvent removal takes place by lyophilization of the bulk matrix, which stabilizes the drug particles during hardening and prevents coalesence, thereby resulting in smaller final drug particles. The method is particularly preferred for protein agents. The process can be used in conjunction with a standard microencapsulation technique, typically following separation of the agent from the macromolecular matrix.Type: GrantFiled: January 12, 2001Date of Patent: April 18, 2006Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Yong S. Jong, Jules S. Jacob
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Publication number: 20040070093Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.Type: ApplicationFiled: August 12, 2003Publication date: April 15, 2004Applicant: Brown University Research FoundationInventors: Edith Mathiowitz, Donald Chickering, Yong S. Jong, Jules S. Jacob
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Patent number: 6696075Abstract: Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics.Type: GrantFiled: August 30, 2002Date of Patent: February 24, 2004Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Jules S. Jacob, Yong S. Jong, Donald E. Chickering, Edwin E. Edwards
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Patent number: 6677313Abstract: The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form, thereby obtaining noninvasive gene delivery for gene therapy.Type: GrantFiled: October 3, 2000Date of Patent: January 13, 2004Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Yong S. Jong, Gerardo Carino, Jules S. Jacob
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Publication number: 20030228367Abstract: Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics.Type: ApplicationFiled: August 30, 2002Publication date: December 11, 2003Applicant: Brown University Research FoundationInventors: Edith Mathiowitz, Jules S. Jacob, Yong S. Jong, Donald E. Chickering, Edwin E. Edwards
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Patent number: 6616869Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.Type: GrantFiled: May 11, 2001Date of Patent: September 9, 2003Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Donald Chickering, III, Yong S. Jong, Jules S. Jacob
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Publication number: 20030104068Abstract: A process is provided for making dry, micronized particles of an agent, such as a drug. The method includes (a) dissolving a macromolecular material, preferably a polymer, in an effective amount of a solvent, to form a solution; (b) dissolving or dispersing the agent in the solution to form a mixture; (c) freezing the mixture; and (d) drying by vacuum the mixture to form solid particles of the agent dispersed in solid macromolecular material. The micronization in this process occurs directly in a macromolecular matrix and hardening of the particles of agent by solvent removal takes place by lyophilization of the bulk matrix, which stabilizes the drug particles during hardening and prevents coalesence, thereby resulting in smaller final drug particles. The method is particularly preferred for protein agents. The process can be used in conjunction with a standard microencapsulation technique, typically following separation of the agent from the macromolecular matrix.Type: ApplicationFiled: April 30, 2002Publication date: June 5, 2003Applicant: Brown University Research FoundationInventors: Edith Mathiowitz, Yong S. Jong, Jules S. Jacob
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Publication number: 20030082236Abstract: A process is provided for making dry, micronized particles of an agent, such as a drug. The method includes (a) dissolving a macromolecular material, preferably a polymer, in an effective amount of a solvent, to form a solution; (b) dissolving or dispersing the agent in the solution to form a mixture; (c) freezing the mixture; and (d) drying by vacuum the mixture to form solid particles of the agent dispersed in solid macromolecular material. The micronization in this process occurs directly in a macromolecular matrix and hardening of the particles of agent by solvent removal takes place by lyophilization of the bulk matrix, which stabilizes the drug particles during hardening and prevents coalesence, thereby resulting in smaller final drug particles. The method is particularly preferred for protein agents. The process can be used in conjunction with a standard microencapsulation technique, typically following separation of the agent from the macromolecular matrix.Type: ApplicationFiled: January 12, 2001Publication date: May 1, 2003Inventors: Edith Mathiowitz, Yong S. Jong, Jules S. Jacob
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Publication number: 20030077317Abstract: Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a base polymer are enhanced by incorporating a short chain polymer with one or more free carboxylic groups into the base polymer to enhance the ability of the base polymer to adhere to a tissue surface such as a mucosal membrane. The short chain polymers can be incorporated within a wide range of base polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, short chain polymers can be incorporated within base polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The short chain polymers can either be solubilized and blended with the base polymer before manufacture or else used as a coating with base polymers over existing systems.Type: ApplicationFiled: May 15, 2002Publication date: April 24, 2003Applicant: Brown University Research FoundationInventors: Camilla A. Santos, Jules S. Jacob, Benjamin A. Hertzog, Gerardo P. Carino, Edith Mathiowitz
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Patent number: 6528035Abstract: Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.Type: GrantFiled: November 6, 2000Date of Patent: March 4, 2003Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Jules S. Jacob, Donald E. Chickering, III, Kathleen Jo Leach
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Patent number: 6511749Abstract: Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.Type: GrantFiled: December 15, 1997Date of Patent: January 28, 2003Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Jules S. Jacob, Donald E. Chickering, III, Kathleen Jo Pekarek
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Publication number: 20020155146Abstract: Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics.Type: ApplicationFiled: March 13, 2000Publication date: October 24, 2002Inventors: Edith Mathiowitz, Jules S. Jacob, Donald E. Chickering, Yong S. Jong, Edwin E. Edwards
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Patent number: 6465002Abstract: Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics.Type: GrantFiled: March 13, 2000Date of Patent: October 15, 2002Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Jules S. Jacob, Yong S. Jong, Donald E. Chickering, III, Edwin E. Edwards
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Publication number: 20020110538Abstract: The invention relates to methods and products for preventing and treating tumors. In particular the invention relates to the use of slow release microparticles containing cytokines, which are directly injected into a tumor, in order to treat the tumor, e.g., cause tumor regression or to prevent tumor growth or metastasis.Type: ApplicationFiled: December 27, 2000Publication date: August 15, 2002Applicant: Health Research, Inc.Inventors: Edith Mathiowitz, Yong S. Jong, Nejat K. Egilmez, Richard B. Bankert, Jules S. Jacob
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Patent number: 6368586Abstract: Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery devices. The bioadhesive properties of a polymer are enhanced by incorporating a anhydrideoligome into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydrideoligomes which enhance the bioadhesive properties of a polymer include water-insoluble anhydrideoligomes such as water-insoluble metal oxides, including oxides of calcium, iron, copper and zinc. The anhydrideoligomes can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, metal oxides can be incorporated within polymers used to form or coat drug delivery devices, such as microspheres, which contain a drug or diagnostic agent.Type: GrantFiled: March 27, 2000Date of Patent: April 9, 2002Assignee: Brown University Research FoundationInventors: Jules S. Jacob, Edith Mathiowitz