Patents by Inventor Julia Alterman

Julia Alterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR SIRNA TREATMENT OF MUSCULAR DYSTROPHY
    Publication number: 20240352459
    Abstract: The present invention is related to the treatment of muscular dystrophy. In particular, compositions of short interfering ribonucleic acids (siRNAs) Eire contemplated that are targeted to different portions of a DUX4 messenger ribonucleic acid molecule. Preferably, these siRNAs are double stranded having a sense strand of fifteen (15) nucleotides. When applied as a therapeutic method, the short interfering ribonucleic acids reduce DUX4 protein translation and mediate a therapeutic response in human facioscapulohumeral muscular dystrophies, FSHD 1 and FSHD2.
    Type: Application
    Filed: August 9, 2022
    Publication date: October 24, 2024
    Inventors: Charles P. EMERSON, Katelyn DAMAN, Jing YAN, Anastasia KHVOROVA, Annabelle BISCANS, Julia ALTERMAN
  • DENDRITIC CONJUGATES FOR THE SKIN DELIVERY OF THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20240350526
    Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the skin. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.
    Type: Application
    Filed: March 1, 2024
    Publication date: October 24, 2024
    Inventors: Hassan H. Fakih, Hanadi Sleiman, Anastasia Khvorova, Qi Tang, Katherine Gross, John E. Harris, Julia Alterman, Mohammad Zain Ul Abideen, Raymond Furgal
  • TOPICAL DELIVERY OF THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20240325546
    Abstract: This disclosure provides compositions, systems, and methods for the topical delivery of therapeutic oligonucleotides with microneedle particles.
    Type: Application
    Filed: March 1, 2024
    Publication date: October 3, 2024
    Inventors: Hassan H. Fakih, Hanadi Sleiman, Anastasia Khvorova, Qi Tang, John E. Harris, Julia Alterman, Mohammad Zain Ul Abideen, Raymond Furgal
  • MODIFIED OLIGONUCLEOTIDES TARGETING SNPs
    Publication number: 20240327836
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Application
    Filed: January 24, 2024
    Publication date: October 3, 2024
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • OLIGONUCLEOTIDES FOR HTT-1A MODULATION
    Publication number: 20240301410
    Abstract: This disclosure relates to novel HTT-1A targeting sequences. Novel HTT-1A targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: February 1, 2024
    Publication date: September 12, 2024
    Inventors: Anastasia Khvorova, Julia Alterman, Socheata Ly, Faith Conroy, Daniel O'Reilly, Sarah Allen
  • BRANCHED OLIGONUCLEOTIDES
    Publication number: 20240293550
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: December 26, 2023
    Publication date: September 5, 2024
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • Two-tailed self-delivering siRNA
    Patent number: 12049627
    Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: July 30, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Matthew Hassler
  • Modified oligonucleotides targeting SNPs
    Patent number: 12024706
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: July 2, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • MODIFIED OLIGONUCLEOTIDES TARGETING SNPs
    Publication number: 20240132888
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Application
    Filed: August 9, 2023
    Publication date: April 25, 2024
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Branched oligonucleotides
    Patent number: 11896669
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • Modified oligonucleotides targeting SNPs
    Patent number: 11827882
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: November 28, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Modified oligonucleotides targeting SNPs
    Patent number: 11767527
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: September 26, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20220251554
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: November 29, 2021
    Publication date: August 11, 2022
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES
    Publication number: 20220251555
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Application
    Filed: January 20, 2022
    Publication date: August 11, 2022
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov
  • OLIGONUCLEOTIDES FOR HTT-1A MODULATION
    Publication number: 20220090069
    Abstract: This disclosure relates to novel HTT-1A targeting sequences. Novel HTT-1A targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: August 2, 2021
    Publication date: March 24, 2022
    Inventors: Anastasia Khvorova, Julia Alterman, Socheata Ly, Faith Conroy, Daniel O'Reilly
  • O-methyl rich fully stabilized oligonucleotides
    Patent number: 11279930
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: March 22, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 11230713
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: January 25, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • TWO-TAILED SELF-DELIVERING SIRNA
    Publication number: 20210139901
    Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
    Type: Application
    Filed: October 15, 2020
    Publication date: May 13, 2021
    Inventors: Anastasia Khvorova, Julia Alterman, Matthew Hassler
  • O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES
    Publication number: 20210115442
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Application
    Filed: August 21, 2020
    Publication date: April 22, 2021
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov
  • BRANCHED OLIGONUCLEOTIDES
    Publication number: 20210085793
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: September 4, 2020
    Publication date: March 25, 2021
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho