Patents by Inventor Julia Alterman

Julia Alterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED OLIGONUCLEOTIDES TARGETING SNPs
    Publication number: 20240132888
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Application
    Filed: August 9, 2023
    Publication date: April 25, 2024
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Branched oligonucleotides
    Patent number: 11896669
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • Modified oligonucleotides targeting SNPs
    Patent number: 11827882
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: November 28, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Modified oligonucleotides targeting SNPs
    Patent number: 11767527
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: September 26, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20220251554
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: November 29, 2021
    Publication date: August 11, 2022
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES
    Publication number: 20220251555
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Application
    Filed: January 20, 2022
    Publication date: August 11, 2022
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov
  • OLIGONUCLEOTIDES FOR HTT-1A MODULATION
    Publication number: 20220090069
    Abstract: This disclosure relates to novel HTT-1A targeting sequences. Novel HTT-1A targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: August 2, 2021
    Publication date: March 24, 2022
    Inventors: Anastasia Khvorova, Julia Alterman, Socheata Ly, Faith Conroy, Daniel O'Reilly
  • O-methyl rich fully stabilized oligonucleotides
    Patent number: 11279930
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: March 22, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 11230713
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: January 25, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • TWO-TAILED SELF-DELIVERING SIRNA
    Publication number: 20210139901
    Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
    Type: Application
    Filed: October 15, 2020
    Publication date: May 13, 2021
    Inventors: Anastasia Khvorova, Julia Alterman, Matthew Hassler
  • O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES
    Publication number: 20210115442
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Application
    Filed: August 21, 2020
    Publication date: April 22, 2021
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov
  • BRANCHED OLIGONUCLEOTIDES
    Publication number: 20210085793
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: September 4, 2020
    Publication date: March 25, 2021
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • MODIFIED OLIGONUCLEOTIDES TARGETING SNPs
    Publication number: 20210071177
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Application
    Filed: August 7, 2020
    Publication date: March 11, 2021
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • FULLY STABILIZED ASYMMETRIC SIRNA
    Publication number: 20210024926
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: July 13, 2020
    Publication date: January 28, 2021
    Inventors: Anastasia Khvorova, Neil Aronin, Matthew Hassler, Julia Alterman
  • Two-tailed self-delivering siRNA
    Patent number: 10844377
    Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: November 24, 2020
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Matthew Hassler
  • Branched oligonucleotides
    Patent number: 10799591
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: October 13, 2020
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20200308584
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: March 6, 2020
    Publication date: October 1, 2020
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 10774327
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: September 15, 2020
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • MODIFIED OLIGONUCLEOTIDES TARGETING SNPs
    Publication number: 20200123543
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Application
    Filed: August 9, 2019
    Publication date: April 23, 2020
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES
    Publication number: 20200087663
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Application
    Filed: August 23, 2019
    Publication date: March 19, 2020
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov