Patents by Inventor Julia Barboza

Julia Barboza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Target enrichment of randomly sheared genomic DNA fragments
    Patent number: 10072260
    Abstract: Provided herein are various methods for enriching a target fragment that is present in randomly sheared genomic DNA. In some embodiments, the method may involve hybridizing randomly sheared genomic DNA to a halo probe to produce a first circular complex, and then enzymatically digesting the overhanging ends of the genomic fragment. Other embodiments may include hybridizing randomly sheared genomic DNA to an RNA oligonucleotide that comprises a region that hybridizes to a fragment of the randomly sheared genomic DNA to produce an RNA/DNA duplex. The overhanging ends of the genomic fragment in the RNA/DNA duplex can then be enzymatically digested.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: September 11, 2018
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Scott Robert Happe, Emily Marine Leproust, Julia Barboza, Joseph Hoang Hai Ong
  • Restriction Enzyme-Free Target Enrichment
    Publication number: 20150307875
    Abstract: Provided herein are various methods for enriching a target fragment that is present in randomly sheared genomic DNA. In some embodiments, the method may involve hybridizing randomly sheared genomic DNA to a halo probe to produce a first circular complex, and then enzymatically digesting the overhanging ends of the genomic fragment. Other embodiments may include hybridizing randomly sheared genomic DNA to an RNA oligonucleotide that comprises a region that hybridizes to a fragment of the randomly sheared genomic DNA to produce an RNA/DNA duplex. The overhanging ends of the genomic fragment in the RNA/DNA duplex can then be enzymatically digested.
    Type: Application
    Filed: October 3, 2013
    Publication date: October 29, 2015
    Inventors: Scott Robert Happe, Emily Marine Leproust, Julia Barboza, Joseph Hoang Hai Ong