Abstract: The invention relates to a bioactive medical product, or dressing, characterised in that it comprises at least an inner layer formed by a hydrogel and an outer layer formed by a biodegradable and bioabsorbable polyurethane, said inner layer being impregnated with an N-terminal peptide of 20 amino acids of pro-adrenomedullin and the outer layer being impregnated with nanoparticles of bemiparin encapsulated in a biodegradable copolymer or polymer. The active components can be dosed in a sequential and controlled manner with this composition. The invention also relates to a method for producing the two-layer dressing and to the use thereof in medicine, said dressing being specially designed to treat and promote the healing of wounds, such as compromised wounds and ulcers, particularly in patients with diabetes and reduced blood supply.

Abstract: The invention relates to a prosthesis that can be implanted in the center of wall wound scarring. The inventive prosthesis, which is intended for use in abdominal surgery, is provided with a geometric shape in the form of sheets that converge in dihedral angles. The sheets or planes are made from a synthetic biotolerated material in porous form with large pores. One of the planes is inserted into the center of the scarring between the two aponeurotic surfaces to be joined. The other plane(s) of the prosthesis, which is perpendicular to the aforementioned plane, is arranged so as to overlap the aponeurotic edges of the edge of the section. The proliferation obtained around the prosthesis, in the scarring center and close thereto, provides stress resistance greater than that obtained in standard closures, thereby greatly reducing the risk of hernias caused by a badly healed wound.

Abstract: An implantable prosthesis for use in abdominal and thoracic surgery, in the form of a tini sheet. One of the sheet's surfaces is of a linear continuous, non-porous structure and is capable of sustaining the growth of mesothelial cells. This impedes adhesion fomation and fistulization of the viscera On the sheet's other surface, the material is discontinuous in structure with physical voids that stimulate and modulate fibroblast proliferation and collagen deposition, achieving the repair of the original defect by connective tissue. This side of the prosthesis is able to fuilly integrate within host tissue, Due to its lack of excess material, the risk of microorganisms settling on this side and of chronic infection is reduced.