Patents by Inventor Julia Fakhiri

Julia Fakhiri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATED CAS-INHIBITORS
    Publication number: 20210198328
    Abstract: The present invention relates to a polynucleotide encoding a fusion polypeptide comprising an anti-CRISPR (Acr) polypeptide, wherein said fusion polypeptide further comprises a receptor domain changing conformation upon reception of a stimulus. The present invention also relates to a vector comprising the polynucleotide of the present invention, to a bipartite Acr polypeptide comprising a first partial Acr polypeptide comprising amino acids corresponding to amino acids 10 to 62 of SEQ ID NO: 1, and a second partial Acr polypeptide comprising amino acids corresponding to amino acids 67 to 77 of SEQ ID NO: 1, and to a host cell comprising the aforesaid polynucleotide compounds. The present invention also relates to the said compounds for use in medicine, in particular for use in treatment and/or prevention of genetic disease, neurodegenerative disease, cancer, and/or infectious disease. Moreover, the present invention also relates to a kit, methods, and uses related thereto.
    Type: Application
    Filed: October 5, 2018
    Publication date: July 1, 2021
    Inventors: Dominik Niopek, Roland Eils, Felix Bubeck, Dirk Grimm, Mareike Daniela Hoffmann, Max Christian Waldhauer, Laura Dietz, Julia Fakhiri, Andreas Bietz
  • USE OF ANTI-CRISPR POLYPEPTIDES FOR SPECIFIC ACTIVATION OF CAS NUCLEASES
    Publication number: 20200270603
    Abstract: The present invention relates to a polynucleotide comprising (i) a sequence encoding an anti-CRISPR (Acr) polypeptide and (ii) an miRNA target sequence and to vectors and host cells related thereto.
    Type: Application
    Filed: August 17, 2018
    Publication date: August 27, 2020
    Inventors: Dominik Niopek, Roland Eils, Dirk Grimm, Mareike Daniela Hoffmann, Claire Domenger, Julia Fakhiri, Sabine Aschenbrenner, Carolin Schmelas
  • MEANS AND METHODS FOR INACTIVATING THERAPEUTIC DNA IN A CELL
    Publication number: 20190119678
    Abstract: The present invention relates to a method for inactivating a therapeutic polynucleotide in a host cell, comprising (a) contacting said host cell with a clustered regularly interspaced short palindromic repeats (CRISPR) RNA (gRNA) specifically hybridizing to said therapeutic polynucleotide and with a CRISPR-associated endonuclease, and, thereby, (b) inactivating said therapeutic polynucleotide.
    Type: Application
    Filed: April 18, 2017
    Publication date: April 25, 2019
    Inventors: Dirk Grimm, Julia Fakhiri