Patents by Inventor Julia Frei
Julia Frei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11905322Abstract: Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD- L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.Type: GrantFiled: May 3, 2021Date of Patent: February 20, 2024Assignee: Albert Einstein College of MedicineInventors: Jonathan R. Lai, Steven Almo, Nina Liu, Julia Frei
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Publication number: 20220372079Abstract: Specific resurfaced Dengue virus glycoprotein subunit E DIII variants and their uses in preventing and treating Dengue virus infection are disclosed. Provided herein are specific resurfaced Zika virus glycoprotein subunit E DIII variants and their uses in preventing and treating Zika virus infection. Multivalent vaccines comprising such resurfaced EDIII variants are also described, in addition to nanoparticle conjugated resurfaced EDIII variants.Type: ApplicationFiled: June 24, 2020Publication date: November 24, 2022Inventors: Jonathan R. Lai, Julia Frei, Olivia Vergnolle, Elisabeth Nyakatura, George Georgiev, Ariel Wirchnianski
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Publication number: 20220218824Abstract: Methods for treating and for preventing filovirus infections are disclosed, as well as compositions therefor.Type: ApplicationFiled: September 28, 2021Publication date: July 14, 2022Inventors: Jonathan R. Lai, Julia Frei, Elisabeth Nyakatura
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Patent number: 11352413Abstract: Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD-L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.Type: GrantFiled: May 9, 2017Date of Patent: June 7, 2022Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINEInventors: Jonathan R. Lai, Steven Almo, Nina Liu, Julia Frei
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Publication number: 20220133904Abstract: The present invention relates to a method for generating an antibody-payload conjugate by means of a microbial transglutaminase (MTG). The method comprises a step of conjugating a linker comprising or having the peptide structure (shown in N->C direction) Gly-(Aax)m-B-(Aax)n via the N-terminal primary amine of the N-terminal glycine (Gly) residue to a glutamine (Gln) residue comprised in the heavy or light chain of an antibody.Type: ApplicationFiled: March 19, 2020Publication date: May 5, 2022Inventors: Roger SCHIBLI, Martin BEHE, Philipp SPYCHER, Julia FREI, Jöri WEHRMÜLLER
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Publication number: 20220098274Abstract: Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD-L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.Type: ApplicationFiled: May 3, 2021Publication date: March 31, 2022Inventors: Jonathan R. Lai, Steven Almo, Nina Liu, Julia Frei
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Patent number: 11135292Abstract: Methods for treating and for preventing filovirus infections are disclosed, as well as compositions therefor.Type: GrantFiled: August 22, 2019Date of Patent: October 5, 2021Assignee: Albert Einstein College of MedicineInventors: Jonathan R. Lai, Julia Frei, Elisabeth Nyakatura
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Publication number: 20210292394Abstract: The present invention addresses a need for antibodies useful for filovirus infections.Type: ApplicationFiled: December 28, 2020Publication date: September 23, 2021Inventors: Jonathan R. Lai, Jayne F.. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Samantha Zak
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Patent number: 10875907Abstract: The present invention addresses a need for antibodies useful for filovirus infections.Type: GrantFiled: September 18, 2018Date of Patent: December 29, 2020Assignees: Albert Einstein College of Medicine, The Governing Council of the University of Toronto, The Government of the United States as Represented by the Secretary of the ArmyInventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Samantha Zak
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Publication number: 20190374640Abstract: Methods for treating and for preventing filovirus infections are disclosed, as well as compositions therefor.Type: ApplicationFiled: August 22, 2019Publication date: December 12, 2019Inventors: Jonathan R. Lai, Julia Frei, Elisabeth Nyakatura
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Patent number: 10435461Abstract: The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.Type: GrantFiled: August 6, 2015Date of Patent: October 8, 2019Assignees: Albert Einstein College of Medicine, The Governing Council of the University of Toronto, The Government of the United States as Represented by the Secretary of the ArmyInventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Samantha Zak
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Patent number: 10391171Abstract: Methods for treating and for preventing Filovirus infections are disclosed, as well as compositions therefor.Type: GrantFiled: January 12, 2017Date of Patent: August 27, 2019Assignee: Albert Einstein College of MedicineInventors: Jonathan R. Lai, Julia Frei, Elisabeth Nyakatura
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Publication number: 20190185547Abstract: The present invention addresses a need for antibodies useful for filovirus infections.Type: ApplicationFiled: September 18, 2018Publication date: June 20, 2019Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., THE GOVERNING COUNCEL OF THE UNIVERSITY OF TORONTO, THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMYInventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Samantha Zak
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Publication number: 20190127439Abstract: Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD-L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.Type: ApplicationFiled: May 9, 2017Publication date: May 2, 2019Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.Inventors: Jonathan R. Lai, Steven Almo, Nina Liu, Julia Frei
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Patent number: 10081669Abstract: The present invention addresses a need for improved treatments for Filovirus infections.Type: GrantFiled: May 23, 2016Date of Patent: September 25, 2018Assignees: Albert Einstein College of Medicine, Inc., The Governing Council of the University of Toronto, The United States of America as Represented by the Secretary of the ArmyInventors: Jonathan R. Lai, Jayne F. Koelhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Jr., Samantha Zak
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Publication number: 20170204166Abstract: The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.Type: ApplicationFiled: August 6, 2015Publication date: July 20, 2017Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, U.S. ARMY MEDICAL RESEARCH AND MATERIAL COMMANDInventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Samantha Zak
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Publication number: 20170182163Abstract: Methods for treating and for preventing Filovirus infections are disclosed, as well as compositions therefor.Type: ApplicationFiled: January 12, 2017Publication date: June 29, 2017Applicant: Albert Einstein College of Medicine, Inc.Inventors: Jonathan R. Lai, Julia Frei, Elisabeth Nyakatura
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Publication number: 20170088606Abstract: The present invention addresses a need for improved treatments for Filovirus infections.Type: ApplicationFiled: May 23, 2016Publication date: March 30, 2017Applicant: Albert Einstein College of Medicine, Inc.Inventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, JR., Samantha Zak
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Patent number: 9346875Abstract: The present invention addresses a need for improved treatments for filovirus infections.Type: GrantFiled: May 30, 2014Date of Patent: May 24, 2016Assignees: Albert Einstein College of Medicine, Inc., The Governing Council of the University of Toronto, The United States of America as Represented by the Secretary of the ArmyInventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Jr., Samantha Zak
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Publication number: 20140356354Abstract: The present invention addresses a need for improved treatments for filovirus infections.Type: ApplicationFiled: May 30, 2014Publication date: December 4, 2014Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, University of Toronto, Government of the United StatesInventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, JR., Samantha Zak
