Patents by Inventor Julia Golova

Julia Golova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7829644
    Abstract: New gel-forming reagents including monomers and cross-linkers, which can be applied to gel-drop microarray manufacturing by using co-polymerization approaches are disclosed. Compositions for the preparation of co-polymerization mixtures with new gel-forming monomers and cross-linker reagents are described herein. New co-polymerization compositions and cross-linkers with variable length linker groups between unsaturated C?C bonds that participate in the formation of gel networks are disclosed.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: November 9, 2010
    Assignee: UChicago Argonne, LLC
    Inventors: Julia Golova, Boris Chernov, Alexander Perov
  • Publication number: 20070249797
    Abstract: New gel-forming reagents including monomers and cross-linkers, which can be applied to gel-drop microarray manufacturing by using co-polymerization approaches are disclosed. Compositions for the preparation of co-polymerization mixtures with new gel-forming monomers and cross-linker reagents are described herein. New co-polymerization compositions and cross-linkers with variable length linker groups between unsaturated C?C bonds that participate in the formation of gel networks are disclosed.
    Type: Application
    Filed: October 18, 2006
    Publication date: October 25, 2007
    Applicant: UChicago Argonne LLC
    Inventors: Julia Golova, Boris Chernov, Alexander Perov
  • Publication number: 20070238163
    Abstract: Described herein is a novel approach for the immobilization of one or more biomolecules or biomolecule complexes to solid supports. The method describes the modification of a solid support, if required, attaching functionality to a biomolecule or biomolecule complex, and linking the biomolecule or biomolecule complex to the solid support. The described complexes are rapidly produced while conserving both orientation and functional activity of the utilized biomolecule or biomolecule complex. Thus, materials produced by this method thus have applications as nanomaterials for biosensor fabrication, screening microarrays, high-throughput drug discovery, and as a tool for combinatorial chemistry, to name only a few.
    Type: Application
    Filed: April 5, 2006
    Publication date: October 11, 2007
    Inventors: Julia Golova, Boris Chernov, Alexander Kukhtin
  • Publication number: 20070031862
    Abstract: Plastic substrates, including poly(methyl methacrylate) (PMMA) and poly(ethylene terephthalate) (PET) slides, may be modified with methods described herein and subsequently used in the manufacture or formation of biochips, or other microarrays. Illustrative methods include modifying the surface of the plastic substrates by covalent attachment of unsaturated acid derivatives that include a primary amine group for reacting with functional groups on the surface of the plastic substrate. Further illustrative methods include modifying the surface of the plastic substrates by a cleaning procedure that results in improved adhesive properties for subsequent printing. After being modified, the substrates described herein may be used to prepare 2D and 3D microarrays by printing using conventional methods.
    Type: Application
    Filed: June 21, 2006
    Publication date: February 8, 2007
    Applicant: The University of Chicago
    Inventors: Boris Chernov, Julia Golova, Darrell Chandler
  • Publication number: 20060194213
    Abstract: New modifiers were synthesized for incorporation of a methacrylic function in 3?-, 5?- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of 5?-methacrylated oligonucleotides for preparation of microarrays by a co-polymerization method.
    Type: Application
    Filed: February 25, 2005
    Publication date: August 31, 2006
    Inventors: Julia Golova, Boris Chernov
  • Patent number: 7049073
    Abstract: This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linker for immobilization on a matrix. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays. DNA-DNA and DNA-protein interactions are investigated using the microarrays.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: May 23, 2006
    Assignee: The University of Chicago
    Inventors: Boris Chernov, Julia Golova
  • Publication number: 20060063147
    Abstract: ?-Amino-PEG conjugates, and processes and reagents for preparing ?-amino-PEG conjugates are described.
    Type: Application
    Filed: September 21, 2004
    Publication date: March 23, 2006
    Inventors: Boris Chernov, Alexander Kukhtin, Julia Golova
  • Publication number: 20050208199
    Abstract: Methods and compositions for 3?-aminomodifier CPG and 3?-aminomodified oligonucleotides are disclosed. Microarrays or biochips with 3?-aminomodified oligonucleotides are disclosed. A variety of detectable labels can be attached to 3?-aminomodified oligonucleotides.
    Type: Application
    Filed: March 18, 2004
    Publication date: September 22, 2005
    Inventors: Julia Golova, Boris Chernov, Alexander Kukhtin
  • Publication number: 20050042363
    Abstract: Macroporous polymer substrates have greater immobilization capacity for large biomolecules and better access for analytes than substrates used previously for microarrays. Microarrays are fabricated with macroporous polymer substrates, and nucleic acids, proteins and peptides are immobilized in the substrate. Microarrays with macroporous polymer substrates are useful in immunoassays, drug discovery studies and other biotechnological applications that involve large scale macromolecular interactions. Nucleic acid hybridizations, protein binding, and antigen-antibody interactions are analyzed using microarrays with macroporous polymer substrates.
    Type: Application
    Filed: August 18, 2003
    Publication date: February 24, 2005
    Inventors: Alexander Kukhtin, Boris Chernov, Julia Golova, Gennadiy Yershov, Margaret Gemmell
  • Publication number: 20040086866
    Abstract: This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linker for immobilization on a matrix. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays. DNA-DNA and DNA-protein interactions are investigated using the microarrays.
    Type: Application
    Filed: October 30, 2002
    Publication date: May 6, 2004
    Inventors: Boris Chernov, Julia Golova