Patents by Inventor Julia Hegge

Julia Hegge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intravenous delivery of polynucleotides to cells in mammalian limb
    Patent number: 7803782
    Abstract: An intravenous delivery method is described that enables delivery of polynucleotides to extravascular cells of a mammalian limb. The method involves the injection of polynucleotides into a distal vein of a limb that is transiently occluded. Polynucleotide delivery is facilitated by rapid injection in sufficient volume to enable extravasation of the solution into surrounding tissue.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: September 28, 2010
    Assignee: Roche Madison Inc.
    Inventors: James E. Hagstrom, Julia Hegge, Hans Herweijer, Jon A. Wolff
  • Process for delivering sirna to cardiac muscle tissue
    Patent number: 7781415
    Abstract: A process for delivering a polynucleotide to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a polynucleotide into a blood vessel and increasing permeability of the blood vessel to the polynucleotide. The polynucleotide can be a small interfering RNA or microRNA and inhibit gene expression in the cell.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: August 24, 2010
    Assignee: Roche Madison Inc.
    Inventors: Hans Herweijer, Julia Hegge, Jon A. Wolff, David L. Lewis
  • Delivery of molecules and complexes to mammalian cells in vivo
    Patent number: 7589059
    Abstract: Disclosed is a system for providing in vivo delivery of molecules or complexes to extravascular mammalian cells using an intravascular administration route. The molecules or complexes are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate transiently increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the molecule to the cell.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: September 15, 2009
    Assignee: Roche Madison Inc.
    Inventors: Jon A. Wolff, Vladimir G. Budker, Hans Herweijer, James E. Hagstrom, Sean D. Monahan, Julia Hegge, Vladimir Subbotin
  • Nucleic acid injected into hepatic vein lumen
    Patent number: 7547683
    Abstract: Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: June 16, 2009
    Assignee: Roche Madison, Inc.
    Inventors: Jon A. Wolff, Tatyana Budker, legal representative, Julia Hegge, James E. Hagstrom, Vladimir G. Budker
  • Intravascular delivery of nucleic acid
    Patent number: 7473419
    Abstract: Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: January 6, 2009
    Assignee: Roche Madison Inc.
    Inventors: Jon A. Wolff, James E. Hagstrom, Hans Herweijer, Vladimir G. Budker, Julia Hegge
  • Process for delivery of polynucleotides to the prostate
    Patent number: 7435723
    Abstract: Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the polynucleotide to the cell.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: October 14, 2008
    Assignee: Mirus Bio Corporation
    Inventors: James E. Hagstrom, Mark Noble, Julia Hegge, Vladimir G. Budker
  • Endosomolytic Polymers
    Publication number: 20070105804
    Abstract: Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.
    Type: Application
    Filed: October 10, 2006
    Publication date: May 10, 2007
    Applicant: MIRUS BIO CORPORATION
    Inventors: Jon Wolff, Julia Hegge, James Hagstrom, Vladimir Budker
  • Devices and processes for distribution of genetic material to mammalian limb
    Patent number: 7214369
    Abstract: A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: May 8, 2007
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Julia Hegge, Vladimir Subbotin
  • Nucleic acid injected into hapatic vein lumen and delivered to primate liver
    Patent number: 7144869
    Abstract: Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: December 5, 2006
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, Julia Hegge, James E. Hagstrom, Vladimir G. Budker
  • Nucleic acid injected into hapatic vein lumen and delivered to primate liver
    Publication number: 20060189553
    Abstract: Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.
    Type: Application
    Filed: December 5, 2002
    Publication date: August 24, 2006
    Inventors: Jon Wolff, Julia Hegge, James Hagstrom, Vladimir Budker
  • Direct DNA delivery to bone cells
    Publication number: 20060115462
    Abstract: An method is described that enables in vivo delivery of polynucleotides to cells of a mammalian bone limb. The method involves the injection of polynucleotides in a large volume into the lumen of the bone.
    Type: Application
    Filed: November 23, 2005
    Publication date: June 1, 2006
    Inventors: Vladimir Subbotin, Julia Hegge
  • Intravascular delivery of nucleic acid
    Publication number: 20060093584
    Abstract: Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
    Type: Application
    Filed: November 7, 2005
    Publication date: May 4, 2006
    Inventors: Jon Wolff, James Hagstrom, Hans Herweijer, Vladimir Budker, Julia Hegge
  • Intravascular delivery of nucleic acid
    Patent number: 7015040
    Abstract: Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: March 21, 2006
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Julia Hegge, Hans Herweijer
  • Intravascular delivery of nucleic acid
    Publication number: 20050182013
    Abstract: Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
    Type: Application
    Filed: December 10, 2004
    Publication date: August 18, 2005
    Inventors: Jon Wolff, Vladimir Budker, James Hagstrom, Julia Hegge
  • Intravascular delivery of non-viral nucleic acid
    Publication number: 20050153451
    Abstract: Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
    Type: Application
    Filed: October 28, 2004
    Publication date: July 14, 2005
    Inventors: Jon Wolff, Vladimir Budker, James Hagstrom, Hans Herweijer, Julia Hegge, Paul Slattum, Sean Monahan, David Rozema
  • Process of delivering a virally encapsulated polynucleotide or viral vector to a parenchymal cell via the vascular system
    Publication number: 20050129660
    Abstract: A process for delivering a polynucleotide into a parenchymal cell in a mammal, comprising, transporting the polynucleotide into a vessel communicating with the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell. More specifically, the polynucleotide consists of a viral vector.
    Type: Application
    Filed: December 11, 2003
    Publication date: June 16, 2005
    Inventors: James Hagstrom, Jon Wolff, Vladimir Budker, Julia Hegge, Hans Herweijer
  • Intravenous delivery of polynucleotides to cells in mammalian limb
    Publication number: 20040242528
    Abstract: An intravenous delivery method is described that enables delivery of polynucleotides to extravascular cells of a mammalian limb. The method involves the injection of polynucleotides into a distal vein of a limb that is transiently occluded. Polynucleotide delivery is facilitated by rapid injection in sufficient volume to enable extravasation of the solution into surrounding tissue.
    Type: Application
    Filed: May 27, 2004
    Publication date: December 2, 2004
    Inventors: James E. Hagstrom, Julia Hegge
  • Devices and processes for distribution of genetic material to mammalian limb
    Publication number: 20040224879
    Abstract: A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.
    Type: Application
    Filed: May 5, 2003
    Publication date: November 11, 2004
    Inventors: Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Julia Hegge, Vladimir Subbotin
  • Process for delivering sirna to cardiac muscle tissue
    Publication number: 20040157790
    Abstract: A process for delivering a polynucleotide to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a polynucleotide into a blood vessel and increasing permeability of the blood vessel to the polynucleotide. The polynucleotide can be a small interfering RNA or microRNA and inhibit gene expression in the cell.
    Type: Application
    Filed: February 3, 2004
    Publication date: August 12, 2004
    Inventors: Hans Herweijer, Julia Hegge, Jon A. Wolff, David L. Lewis
  • Nucleic acid injected into hapatic vein lumen and delivered to primate liver
    Publication number: 20040110697
    Abstract: Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.
    Type: Application
    Filed: December 5, 2002
    Publication date: June 10, 2004
    Inventors: Jon A. Wolff, Julia Hegge, James E. Hagstrom, Vladimir G. Budker