Abstract: Described are methods and systems for calibrating simulation models to generate digital twins for physical entities. In some embodiments, a method includes receiving a plurality of datasets for a plurality of corresponding physical entities. A calibration request is enqueued to a calibration requests queue for each received dataset and includes information indicating a dataset and a corresponding physical entity. A plurality of calibration engines and a plurality of corresponding simulation clusters for generating a plurality of calibration results for a plurality of calibration requests dequeued from the calibration requests queue can be deployed.

Abstract: A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.

Abstract: Described are methods and systems for calibrating simulation models to generate digital twins for physical entities. In some embodiments, a method includes receiving a plurality of datasets for a plurality of corresponding physical entities. A calibration request is enqueued to a calibration requests queue for each received dataset and includes information indicating a dataset and a corresponding physical entity. A plurality of calibration engines and a plurality of corresponding simulation clusters for generating a plurality of calibration results for a plurality of calibration requests dequeued from the calibration requests queue can be deployed.

Abstract: A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.

Abstract: Described are methods and systems for calibrating simulation models to generate digital twins for physical entities. In some embodiments, a method includes receiving a plurality of datasets for a plurality of corresponding physical entities. A calibration request is enqueued to a calibration requests queue for each received dataset and includes information indicating a dataset and a corresponding physical entity. A plurality of calibration engines and a plurality of corresponding simulation clusters for generating a plurality of calibration results for a plurality of calibration requests dequeued from the calibration requests queue can be deployed.

Abstract: A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.