Patents by Inventor Julia Lamenzo

Julia Lamenzo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS
    Publication number: 20160264939
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Application
    Filed: October 13, 2015
    Publication date: September 15, 2016
    Inventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo Fox, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
  • Compositions and methods for promoting the generation of PDX1+ pancreatic cells
    Patent number: 9157062
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: October 13, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo Fox, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L Rubin
  • COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS
    Publication number: 20140335611
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Application
    Filed: May 20, 2014
    Publication date: November 13, 2014
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
  • Compositions and methods for promoting the generation of PDX1+ pancreatic cells
    Patent number: 8728812
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: May 20, 2014
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Shuibing Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
  • Sonic hedgehog modulators
    Patent number: 8530456
    Abstract: The present invention relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in the treatment of proliferative diseases (e.g., basal cell carcinoma, Gorlin syndrome, medulloblastoma, or pancreatic cancer), pulmonary diseases (e.g., interstitial pnuemonitis or interstitial pulmonary fibrosis), and developmental disorders (e.g., phocomelia or cyclopia). Novel non-natural macrocycles are provided that inhibit Sonic Hedgehog induced-protein transcription.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: September 10, 2013
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Lee F. Peng, Julia Lamenzo, Nicole Maloof, Kazuo Nakai, Benjamin Stanton, Sara Jean Buhrlage, Lawrence MacPherson, Michel Weiwer, Stuart L. Schreiber
  • SONIC HEDGEHOG MODULATORS
    Publication number: 20110172233
    Abstract: The present invention relates to relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in the treatment of proliferative diseases (e.g., basal cell carcinoma, Gorlin syndrome, medulloblastoma, or pancreatic cancer), pulmonary diseases (e.g., interstitial pnuemonitis or interstitial pulmonary fibrosis), and developmental disorders (e.g., phocomelia or cyclopia). Novel non-natural macrocycles are provided that inhibit Sonic Hedgehog induced-protein transcription.
    Type: Application
    Filed: April 21, 2009
    Publication date: July 14, 2011
    Inventors: Lee F. Peng, Julia Lamenzo, Nicole Maloof, Kazuo Nakai, Benjamin Stanton, Sara Jean, Lawrence Macpherson, Michel Weiwer, Stuart L. Schreiber
  • COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS
    Publication number: 20110070645
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Application
    Filed: April 22, 2009
    Publication date: March 24, 2011
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Shuibing Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin