Patents by Inventor Julia LEITMAN

Julia LEITMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PERK inhibitors and uses thereof in treating diseases associated with aggregation-prone proteins
    Patent number: 11104651
    Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.
    Type: Grant
    Filed: July 5, 2020
    Date of Patent: August 31, 2021
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Gerardo Zelmar Lederkremer, Julia Leitman, Hagit Eiger, Daniel Offen, Javier Ganz, Moshe Portnoy
  • PERK INHIBITORS AND USES THEREOF IN TREATING DISEASES ASSOCIATED WITH AGGREGATION-PRONE PROTEINS
    Publication number: 20200331865
    Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.
    Type: Application
    Filed: July 5, 2020
    Publication date: October 22, 2020
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Gerardo Zelmar LEDERKREMER, Julia LEITMAN, Hagit EIGER, Daniel OFFEN, Javier GANZ, Moshe PORTNOY
  • Perk inhibitors and uses thereof in treating diseases associated with aggregation-prone proteins
    Patent number: 10723706
    Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: July 28, 2020
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Gerardo Zelmar Lederkremer, Julia Leitman, Hagit Eiger, Daniel Offen, Javier Ganz, Moshe Portnoy
  • PERK INHIBITORS AND USES THEREOF IN TREATING DISEASES ASSOCIATED WITH AGGREGATION-PRONE PROTEINS
    Publication number: 20190010130
    Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.
    Type: Application
    Filed: June 13, 2017
    Publication date: January 10, 2019
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Gerardo Zelmar LEDERKREMER, Julia LEITMAN, Hagit EIGER, Daniel OFFEN, Javier GANZ, MOshe PORTNOY