Patents by Inventor Julia M. Amadio

Julia M. Amadio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20200069700
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia M. AMADIO, Sebastian MIRKIN
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 10568891
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: February 25, 2020
    Assignee: TherapeuticsMD, Inc.
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20190358243
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Application
    Filed: December 7, 2016
    Publication date: November 28, 2019
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian Bernick
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20190343771
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Application
    Filed: May 9, 2018
    Publication date: November 14, 2019
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • Natural combination hormone replacement formulations and therapies
    Publication number: 20190343845
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Application
    Filed: July 23, 2019
    Publication date: November 14, 2019
    Inventors: Brian A. Bernick, Janice Louise Cacace, Peter H.R. Persicaner, Neda Irani, Julia M. Amadio
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 10471072
    Abstract: In one aspect, pharmaceutical compositions and methods for the treatment of vulvovaginal atrophy (VVA) are provided. In one embodiment, the method comprises digitally inserting into the lower third of the vagina of a subject having VVA a soft gelatin capsule containing a liquid pharmaceutical composition.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: November 12, 2019
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Peter H. R. Persicaner, Janice Louise Cacace, Neda Irani, Julia M. Amadio
  • NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES
    Publication number: 20190314386
    Abstract: Pharmaceutical compositions for co-administering estradiol and progesterone to a human subject in need thereof are provided. In some embodiments, the pharmaceutical composition comprises solubilized estradiol, suspended progesterone, and a solubilizing agent comprising a medium chain (C6-C12) oil.
    Type: Application
    Filed: January 9, 2019
    Publication date: October 17, 2019
    Inventors: Brian A. Bernick, Peter H.R. Persicaner, Julia M. Amadio
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 10398708
    Abstract: In one aspect, compositions and methods for the treatment of vulvovaginal atrophy (VVA) are provided. In one embodiment, the method comprises administering an estrogen to a subject having VVA by inserting a dosage form comprising a liquid pharmaceutical composition.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: September 3, 2019
    Assignee: TherapeuticsMD, Inc.
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES
    Publication number: 20190247401
    Abstract: Pharmaceutical compositions for co-administering estradiol and progesterone to a human subject having vasomotor symptoms associated with estrogen deficiency are provided. In some embodiments, the pharmaceutical composition produces certain pharmacokinetic parameters when the composition is administered to the subject.
    Type: Application
    Filed: April 24, 2019
    Publication date: August 15, 2019
    Inventors: Julia M. Amadio, Brian A. Bernick, Sebastian Mirkin
  • Formulations for solubilizing hormones
    Patent number: 10328087
    Abstract: Compositions and methods for the solubilization of steroid hormones are disclosed.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: June 25, 2019
    Assignee: TherapeuticsMD, Inc.
    Inventors: Thorsteinn Thorsteinsson, Frederick D. Sancilio, Brian A. Bernick, Julia M. Amadio
  • Natural combination hormone replacement formulations and therapies
    Publication number: 20190142844
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Application
    Filed: August 16, 2018
    Publication date: May 16, 2019
    Inventors: Brian A. Bernick, Janice Louise Cacace, Peter H.R. Persicaner, Neda Irani, Julia M. Amadio
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 10258630
    Abstract: In one aspect, compositions and methods for the treatment of vulvovaginal atrophy (VVA) are provided. In one embodiment, the method comprises administering an estrogen to a subject having VVA by inserting a dosage form comprising a liquid pharmaceutical composition.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: April 16, 2019
    Assignee: TherapeuticsMD, Inc.
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • Natural combination hormone replacement formulations and therapies
    Patent number: 10206932
    Abstract: Pharmaceutical compositions for co-administering estradiol and progesterone to a human subject in need thereof are provided. In some embodiments, the pharmaceutical composition comprises solubilized estradiol, suspended progesterone, and a solubilizing agent comprising a medium chain (C6-C12) oil.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 19, 2019
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Peter H. R. Persicaner, Julia M. Amadio
  • NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES
    Publication number: 20190046542
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Application
    Filed: August 16, 2018
    Publication date: February 14, 2019
    Applicant: TherapeuticsMD, Inc.
    Inventors: BRIAN A. BERNICK, JANICE LOUISE CACACE, PETER H.R. PERSICANER, NEDA IRANI, JULIA M. AMADIO
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20190022107
    Abstract: The invention described herein relates to pharmaceutical compositions that are capable of delivering active pharmaceutical ingredients, such as estrogens, to the vagina and vagina-associated tissues and related methods of making and using such compositions (e.g., in the treatment of disease). Compositions of the invention are capable of being absorbed by the vagina or vagina-associated tissues such that subjects receiving treatment with the compositions may resume ambulatory activity immediately after receiving the treatment, the frequency or amount of discharge associated with the composition is low or negligible, there is little or no systemic absorption associated with the administration of the active pharmaceutical composition, or results in a combination of any or all thereof.
    Type: Application
    Filed: June 8, 2018
    Publication date: January 24, 2019
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • Progesterone Formulations
    Publication number: 20190008968
    Abstract: Various pharmaceutical formulations are disclosed herein. For example, a pharmaceutical formulation is disclosed comprising ultra-micronized progesterone.
    Type: Application
    Filed: July 17, 2018
    Publication date: January 10, 2019
    Inventors: Brian A. BERNICK, Julia M. AMADIO, Peter H.R. PERSICANER, Janice Louise CACACE, Thorsteinn THORSTEINSSON, Frederick D. SANCILIO
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20180289723
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Application
    Filed: June 12, 2018
    Publication date: October 11, 2018
    Inventors: Brian A. Bernick, Julia M. Amadio, Sebastian Mirkin
  • NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES
    Publication number: 20180280410
    Abstract: Pharmaceutical compositions for co-administering estradiol and progesterone to a human subject having vasomotor symptoms associated with estrogen deficiency are provided. In some embodiments, the pharmaceutical composition produces certain pharmacokinetic parameters when the composition is administered to the subject.
    Type: Application
    Filed: December 5, 2017
    Publication date: October 4, 2018
    Inventors: Julia M. Amadio, Brian A. Bernick, Sebastian Mirkin
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20180256598
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Application
    Filed: May 9, 2018
    Publication date: September 13, 2018
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • Progesterone formulations
    Patent number: 10052386
    Abstract: Various pharmaceutical formulations are disclosed herein. For example, a pharmaceutical formulation is disclosed comprising ultra-micronized progesterone.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: August 21, 2018
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Janice Louise Cacace, Thorsteinn Thorsteinsson, Frederick D. Sancilio