Abstract: The current disclosure provides methods and composition for treatment of autoimmune and inflammatory conditions, including systemic lupus erythematosus and antiphospholipid syndrome. Certain aspects of the disclosure are directed to methods for treatment of an autoimmune or inflammatory condition comprising administering a composition comprising a therapeutically effective amount of NAPc2 or NAPc2/proline. Further aspects include pharmaceutical compositions comprising NAPc2 or NAPc2/proline and, in some cases, one or more additional anti-inflammatory agents.

Abstract: A method for non-invasive detection of ingested medication which provide for one or more processors to receive images of medications designated for a user prior to ingestion of the medications by the user. The one or more processors capture an ultrasound image during ingestion by the user by an ultrasound device removably adhered to a throat area of the user. The one or more processors determine whether contents of the ingestion by the user includes one or more of the medications designated for the user, and responsive to determining the contents of the ingestion by the user includes one or more of the medications designated for the user, the one or more processors generate a confirmation that includes identification of the detected medications ingested by the user.

Abstract: In an approach to automatically downsampling DNA sequence data using variational autoencoders and preserving genomic integrity of an original file embodiments execute, by an encoder, bootstrapping on genomic sequence data to produce resamples. Furthermore, embodiments assess, by the encoder, unrepresentativeness and self-inconsistency of the resamples and selecting a representative resample according to the assessment, and build, by a modified encoder, vector representations from genotype likelihoods based on the selected representative sample. Additionally, embodiments integrate, by an analytics engine, mapping positional information and the genotype likelihoods to identify an optimum vector representation of a resample, and decode, by a modified decoder, the identified optimum vector representation of the resample to obtain a down-sampled read file that resembles and maintains the genomic integrity of the original file.

Abstract: A method for non-invasive detection of ingested medication which provide for one or more processors to receive images of medications designated for a user prior to ingestion of the medications by the user. The one or more processors capture an ultrasound image during ingestion by the user by an ultrasound device removably adhered to a throat area of the user. The one or more processors determine whether contents of the ingestion by the user includes one or more of the medications designated for the user, and responsive to determining the contents of the ingestion by the user includes one or more of the medications designated for the user, the one or more processors generate a confirmation that includes identification of the detected medications ingested by the user.

Abstract: An improved process for the metathetic degradation of nitrile rubber using catalyst systems comprising the catalyst and also a phosphane or diphosphane is provided.

Abstract: A process of degrading nitrile rubbers comprises subjecting them to a metathesis reaction in the presence of specific catalysts with increased activity.

Abstract: New catalyst systems for metathesis reactions, in particular for the metathesis of nitrile rubber, are provided.

Abstract: A novel process for the degradation of nitrile rubber by metathesis using ruthenium- or osmium-based catalysts which have both a substituted or unsubstituted imidazolidine ligand and a carbene ligand bearing a phosphonium radical is provided.