Abstract: A design tool system includes a schematic design tool that computes a total number of devices in an analog circuit schematic based on information extracted from the analog circuit schematic. The schematic design tool selects an optimal row/column device configuration for the total number of devices and creates a temporary layout based upon the optimal row/column device configuration. The schematic design tool computes layout structure data based on the temporary layout and provides the layout structure data to a place and route tool within the design tool system that, in turn, generates a layout based on the layout structure data The design tool system then generates mask layer data based upon the layout that is configured to generate masks for construction of an integrated circuit corresponding to the analog circuit schematic.

Abstract: A design tool system includes a schematic design tool that computes a total number of devices in an analog circuit schematic based on information extracted from the analog circuit schematic. The schematic design tool selects an optimal row/column device configuration for the total number of devices and creates a temporary layout based upon the optimal row/column device configuration. The schematic design tool computes layout structure data based on the temporary layout and provides the layout structure data to a place and route tool within the design tool system that, in turn, generates a layout based on the layout structure data The design tool system then generates mask layer data based upon the layout that is configured to generate masks for construction of an integrated circuit corresponding to the analog circuit schematic.

Abstract: The use of a bacterial secondary metabolite, thaxtomin is described as an effective herbicide on broadleaved, sedge and grass weeds, e.g., in rice fields with no phytotoxicity to rice as well as on aquatic based weeds.

Abstract: The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.

Abstract: The use of a bacterial secondary metabolite, thaxtomin is described as an effective herbicide on broadleaved, sedge and grass weeds, e.g., in rice fields with no phytotoxicity to rice as well as on aquatic based weeds.

Abstract: The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.

Abstract: A method of generating and placing of test structures in test chips comprises creating a control data set for one or more device types, generating a test structure layout in response to the control data set, and placing the test structure layout within a given pad array layout of the at least one pad array as a function of a set of keywords. The control data set includes (i) a set of keywords and (ii) parameter geometries for corresponding ones of test structures associated with the set of keywords. The keywords each define at least (a) one or more pad allocations for each test structure of a given device type, (b) a number quantity of test structures for the given device type, and (c) placement information of the test structures relative to one or more pad allocations of at least one pad array. The pad array layout is configured for enabling a fabrication of corresponding test structures in test chips.

Abstract: A method of generating and placing of test structures in test chips comprises creating a control data set for one or more device types, generating a test structure layout in response to the control data set, and placing the test structure layout within a given pad array layout of the at least one pad array as a function of a set of keywords. The control data set includes (i) a set of keywords and (ii) parameter geometries for corresponding ones of test structures associated with the set of keywords. The keywords each define at least (a) one or more pad allocations for each test structure of a given device type, (b) a number quantity of test structures for the given device type, and (c) placement information of the test structures relative to one or more pad allocations of at least one pad array. The pad array layout is configured for enabling a fabrication of corresponding test structures in test chips.

Abstract: The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.

Abstract: A method of generating a parameterized cell is disclosed herein. The method comprises performing a compiling interpretation on a structure layout. The compiling interpretation includes i) determining and analyzing shape relationships of the structure layout, and ii) mapping shapes and calculating properties of mapped shapes. The method also includes generating code in response to the compiling interpretation, wherein the generated code is representative of one or more parameterized cells of a pcell library of an electronic design automation software program.

Abstract: A method of generating a parameterized cell is disclosed herein. The method comprises performing a compiling interpretation (56) on a structure layout. The compiling interpretation (56) includes i) determining and analyzing shape relationships of the structure layout (72), and ii) mapping shapes and calculating properties of mapped shapes (74). The method also includes generating code (62) in response to the compiling interpretation, wherein the generated code is representative of one or more parameterized cells.

Abstract: The invention provides compounds of formula (1) wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and R2 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The invention also relates to a process for obtaining the compounds, compositions containing them and their therapeutic use. The compounds display excellent activity against mammalian cancer cell lines.

Abstract: A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R1 can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R2 and R3 can be hydrogen, alkyl, or together R2 and R3 form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

Abstract: A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R1 can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R2 and R3 can be hydrogen, alkyl, or together R2 and R3 form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

Abstract: Citreamicins possess useful antitumor activity. Typically they are of formula, wherein R1 is selected from the group consisting of COCH2CH(CH3)2, COCH3 or H when R2 is CH3, or wherein R1 is COCH2CH(CH3)2, and R2 is H.

Abstract: The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.

Abstract: The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.

Abstract: The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.

Abstract: The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.