Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Clear bioavailable liquid softgel fill compositions comprising a) at least one analgesic and one or more of decongestants, expectorants, antitussives and/or antihistamines; b) a matrix comprising a pharmaceutically acceptable poly(alkylene glycol) and a pharmaceutically acceptable alkylene glycol; c) a solubilizing agent comprising a pharmaceutically acceptable polymeric solubilizing agent and water are disclosed. Also disclosed are methods for the preparation of such clear fill compositions, and softgel capsules containing the clear bioavailable liquid fill composition.

Abstract: A system receives vehicle metric data from a gateway device connected to a vehicle. The vehicle gateway device gathers data related to operation of the vehicle and/or location data. The system receives data from multiple vehicles and multiple fleets. The system uses machine learning to identify cohorts for fleets. The system calculates metrics for fleets and benchmarks for the cohorts. The system presents the metrics and benchmarks in a graphical user interface.

Abstract: An analytics reporting system to perform operations that include: aggregating sensor data collected from a plurality of sensor devices within a database, the sensor data comprising a set of values that correspond with a metric; generating a threshold value based on the set of values that correspond with the metric; accessing a portion of the sensor data based on an identifier associated with the portion of the sensor data; determining the portion of the sensor data transgresses the threshold value; and generating a report that comprises a display of the portion of the sensor data based on the determining that the portion of the sensor data transgresses the threshold value.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated fleet tracking. A route management system enables fleet managers to define and assign routes for vehicles in a fleet, as well as set route tracking configurations for customized tracking of the vehicles. For example, the route tracking configuration may include customizations to the scheduled start and/or end time of a route, a threshold for determining that a vehicle has arrived and/or departed from a scheduled stop, and the like.

Abstract: A system, apparatus, and/or method for an aircraft that provides a novel independent-speed variable-frequency generator for aviation power generation. The generator architecture utilizes a 2-stage generator architecture with a wound rotor PM exciter (PME) that provides excitation to the rotor of a generator. A rotating bidirectional AC/DC/AC electric power converter connects the rotor windings of the exciter and the generator.

Abstract: A turboelectric distributed propulsion based on brushless doubly-fed machines (BDFMs) is provided, which minimizes power conversion, enhances mechanical reliability, and strengthens fault-tolerance capability of a DC-based propulsion system. A turboelectric distributed propulsion (TeDP) architecture using BDFMs for aviation applications, and a designed BDFM, inverter, and controller are provided. Simulations and systems are also provided.

Abstract: The present invention relates to bioavailable fill compositions containing one or more of a decongestant, an expectorant, an antitussive, an analgesic, and/or an antihistamine; capsules filled with the bioavailable fill compositions; and methods of making same.

Abstract: An analytics reporting system to perform operations that include: aggregating sensor data collected from a plurality of sensor devices within a database, the sensor data comprising a set of values that correspond with a metric; generating a threshold value based on the set of values that correspond with the metric; accessing a portion of the sensor data based on an identifier associated with the portion of the sensor data; determining the portion of the sensor data transgresses the threshold value; and generating a report that comprises a display of the portion of the sensor data based on the determining that the portion of the sensor data transgresses the threshold value.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated fleet tracking. A route management system enables fleet managers to define and assign routes for vehicles in a fleet, as well as set route tracking configurations for customized tracking of the vehicles. For example, the route tracking configuration may include customizations to the scheduled start and/or end time of a route, a threshold for determining that a vehicle has arrived and/or departed from a scheduled stop, and the like.

Abstract: Clear bioavailable liquid softgel fill compositions comprising a) at least one analgesic and one or more of decongestants, expectorants, antitussives and/or antihistamines; b) a matrix comprising a pharmaceutically acceptable poly(alkylene glycol) and a pharmaceutically acceptable alkylene glycol; c) a solubilizing agent comprising a pharmaceutically acceptable polymeric solubilizing agent and water are disclosed. Also disclosed are methods for the preparation of such clear fill compositions, and softgel capsules containing the clear bioavailable liquid fill composition.

Abstract: A system receives vehicle metric data from a gateway device connected to a vehicle. The vehicle gateway device gathers data related to operation of the vehicle and/or location data. The system receives data from multiple vehicles. The vehicle gateway device gathers vehicle metric data and correlates the metric data with location data. The system presents the correlated data in an interactive map graphical user interface.

Abstract: A turboelectric distributed propulsion based on brushless doubly-fed machines (BDFMs) is provided, which minimizes power conversion, enhances mechanical reliability, and strengthens fault-tolerance capability of a DC-based propulsion system. A turboelectric distributed propulsion (TeDP) architecture using BDFMs for aviation applications, and a designed BDFM, inverter, and controller are provided. Simulations and systems are also provided.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated fleet tracking. A route management system enables fleet managers to define and assign routes for vehicles in a fleet, as well as set route tracking configurations for customized tracking of the vehicles. For example, the route tracking configuration may include customizations to the scheduled start and/or end time of a route, a threshold for determining that a vehicle has arrived and/or departed from a scheduled stop, and the like.

Abstract: A system receives vehicle metric data from a gateway device connected to a vehicle. The vehicle gateway device gathers data related to operation of the vehicle and/or location data. The system receives data from multiple vehicles and multiple fleets. The system uses machine learning to identify cohorts for fleets. The system calculates metrics for fleets and benchmarks for the cohorts. The system presents the metrics and benchmarks in a graphical user interface.

Abstract: Some embodiments of the present invention include a method for processing entities and may include generating, by a computing system, a hierarchical structure representation of entities from a plurality of entities of an object; receiving, by the computing system, information about a current entity; displaying, by the computing system, the current entity and a number of entities related to the current entity using the hierarchical structure representation of the entities, the number of related entities displayed being based on a display range; and updating, by the computing system, the display of the current entity and the related entities based on detecting a scrolling up action on a graphical user interface associated with the computing system.

Abstract: The present invention relates to bioavailable fill compositions containing one or more of a decongestant, an expectorant, an antitussive, an analgesic, and/or an antihistamine; capsules filled with the bioavailable fill compositions; and methods of making same.

Abstract: A method and apparatus for automatically determining that delivery of an untagged item occurred are described. Data is received, from a gateway device located on a vehicle on which the untagged item is transported, where the data includes data collected by the gateway device from a set of devices external to the gateway device. A determination of whether the vehicle stopped is performed based on a first part of the data pertaining to the movement of the vehicle. Automatic determination of whether offload of cargo from the vehicle occurred, is performed based on a second part of the data, which is consistent with activity indicative of the offload of cargo from the vehicle as opposed to data collected based on a tag on an item. Responsive to determining that the offload of cargo from the vehicle occurred, a report including information to be used as proof of delivery is transmitted.

Abstract: Some embodiments of the present invention include a method for processing entities and may include generating, by a computing system, a hierarchical structure representation of entities from a plurality of entities of an object; receiving, by the computing system, information about a current entity; displaying, by the computing system, the current entity and a number of entities related to the current entity using the hierarchical structure representation of the entities, the number of related entities displayed being based on a display range; and updating, by the computing system, the display of the current entity and the related entities based on detecting a scrolling up action on a graphical user interface associated with the computing system.