Patents by Inventor Julian C. Thornton

Julian C. Thornton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7851197
    Abstract: A protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: December 14, 2010
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Peter Kuhnert, Julian C. Thornton, Tracy A. Thornton, legal representative, Michael A. Kuzyk, Jan Burian, Martin Braun
  • Patent number: 7815896
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: October 19, 2010
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Publication number: 20100008895
    Abstract: A protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Application
    Filed: July 8, 2009
    Publication date: January 14, 2010
    Applicant: UNIVERSITAT BERN
    Inventors: JOACHIM FREY, PETER KUHNERT, JULIAN C. THORNTON, TRACY A. THORNTON, MICHAEL A. KUZYK, JAN BURIAN, MARTIN BRAUN
  • Publication number: 20090226462
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Application
    Filed: March 4, 2009
    Publication date: September 10, 2009
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Patent number: 7579011
    Abstract: A novel protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventative, and therapeutic techniques, including the preparation of traditional, recombinant, and improved bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: August 25, 2009
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Peter Kuhnert, Julian C. Thornton, Tracy A. Thornton, legal representative, Michael A. Kuzyk, Jan Burian, Martin Braun
  • Patent number: 7538208
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: May 26, 2009
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Publication number: 20090074817
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Application
    Filed: September 29, 2006
    Publication date: March 19, 2009
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Patent number: 7351550
    Abstract: A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: April 1, 2008
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Peter Kuhnert, Tracy A. Thornton, legal representative, Michael A. Kuzyk, Jan Burian, Martin Braun, Julian C. Thornton
  • Patent number: 7232569
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: June 19, 2007
    Assignee: Universität Bern
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Publication number: 20040086524
    Abstract: The use of the 17 kDa outer surface lipoprotein (OspA) of Piscirickettsia salmonis, or its homologues, as the basis of, or part thereof, a recombinant vaccine for salmonid rickettsial septicaemia and other rickettsial diseases is disclosed. Surface antigens of the bacterial pathogen P. salmonis are characterized and an immunoreactive antigen, namely the 17 kDa outer surface lipoprotein OspA of P. salmonis, as well as the nucleic acid segment that encodes the OspA immunoreactive antigen, is identified and characterized. Diagnostic techniques including the use of hybridization probes and primers as well as the production of specific antigens and antibodies that may be used in immunization techniques for inducing immunity against P. salmonis and other rickettsial diseases are disclosed, as are the development of recombinant vaccines for SRS and other rickettsial diseases based on the 17 kDa lipoprotein OspA.
    Type: Application
    Filed: September 30, 2002
    Publication date: May 6, 2004
    Inventors: Michael A. Kuzyk, Jan Burian, William W. Kay, Julian C. Thornton
  • Publication number: 20030165526
    Abstract: The use of the 17 kDa outer surface lipoprotein (OspA) of Piscirickettsia salmonis, or its homologues, as the basis of, or part thereof, a recombinant vaccine for salmonid rickettsial septicaemia and other rickettsial diseases is disclosed. Surface antigens of the bacterial pathogen P. salmonis are characterized and an immunoreactive antigen, namely the 17 kDa outer surface lipoprotein OspA of P. salmonis, as well as the nucleic acid segment that encodes the OspA immunoreactive antigen, is identified and characterized. Diagnostic techniques including the use of hybridization probes and primers as well as the production of specific antigens and antibodies that may be used in immunization techniques for inducing immunity against P. salmonis and other rickettsial diseases are disclosed, as are the development of recombinant vaccines for SRS and other rickettsial diseases based on the 17 kDa lipoprotein OspA.
    Type: Application
    Filed: September 30, 2002
    Publication date: September 4, 2003
    Inventors: Michael A. Kuzyk, Jan Burian, William W. Kay, Julian C. Thornton
  • Patent number: 5498414
    Abstract: Novel attenuated strains of Aeromonas salmonicida are disclosed that are effective as live effective vaccines against furunculosis in fish. These vaccines may be administered by the immersion of fish in a solution of the vaccine. Methods of producing these strains and other strains having the identifying characteristics of these strains are also disclosed.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: March 12, 1996
    Assignee: University of Victoria
    Inventors: Julian C. Thornton, William W. Kay