Patents by Inventor Julian D. Smith

Julian D. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitroquinolone derivatives
    Patent number: 5376748
    Abstract: A class of optionally 4-substituted 3-nitro-2-oxo-1,2,3,4-tetrahydroquinoline derivatives are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.
    Type: Grant
    Filed: January 7, 1993
    Date of Patent: December 27, 1994
    Assignee: Merck Sharp & Dohme Limited
    Inventors: William R. Carling, Julian D. Smith, Paul D. Leeson
  • Tetrahydroquinoline derivatives useful for neurodegenerative disorders
    Patent number: 5231102
    Abstract: A class of 1,2,3,4-tetrahydroquinolines possessing at least one substituent, or a spirocyclic moiety, at the 4-position, and an acidic group or a group convertible thereto in vivo at the 2-position, are specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment and/or prevention of neurodegenerative disorders.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: July 27, 1993
    Assignee: Merck Sharp & Dohme, Ltd.
    Inventors: Raymond Baker, William R. Carling, Paul D. Leeson, Julian D. Smith