Patents by Inventor Julian Daich
Julian Daich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220226162Abstract: A negative pressure wound treatment system comprising a bandage portion and a negative pressure portion. The bandage portion includes a dressing portion in contact with a wound and a sealing layer positioned in contact with the dressing portion. The sealing layer includes an adhesive creating a seal around the wound. The negative pressure portion is in fluid communication with the bandage portion and includes a first valve and a second valve. The first valve is in fluid communication with the bandage portion and the negative pressure portion. The second valve is in fluid communication with the negative pressure portion and the surrounding environment. The negative pressure wound treatment system is configured to provide negative pressure to an area sealed by the bandage portion upon the actuation of the negative pressure portion. The negative pressure portion is configured to be actuated by compressing the negative pressure portion while walking.Type: ApplicationFiled: April 8, 2022Publication date: July 21, 2022Inventors: Julian DAICH, Giorgio GIATSIDIS, Dennis P. ORGILL
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Patent number: 11324639Abstract: A negative pressure wound treatment system comprising a bandage portion and a negative pressure portion. The bandage portion includes a dressing portion in contact with a wound and a sealing layer positioned in contact with the dressing portion. The sealing layer includes an adhesive creating a seal around the wound. The negative pressure portion is in fluid communication with the bandage portion and includes a first valve and a second valve. The first valve is in fluid communication with the bandage portion and the negative pressure portion. The second valve is in fluid communication with the negative pressure portion and the surrounding environment. The negative pressure wound treatment system is configured to provide negative pressure to an area sealed by the bandage portion upon the actuation of the negative pressure portion. The negative pressure portion is configured to be actuated by compressing the negative pressure portion while walking.Type: GrantFiled: September 21, 2016Date of Patent: May 10, 2022Assignee: Brigham and Women's Hospital, Inc.Inventors: Julian Daich, Giorgio Giatsidis, Dennis P. Orgill
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Publication number: 20180344534Abstract: A negative pressure wound treatment system comprising a bandage portion and a negative pressure portion. The bandage portion includes a dressing portion in contact with a wound and a sealing layer positioned in contact with the dressing portion. The sealing layer includes an adhesive creating a seal around the wound. The negative pressure portion is in fluid communication with the bandage portion and includes a first valve and a second valve. The first valve is in fluid communication with the bandage portion and the negative pressure portion. The second valve is in fluid communication with the negative pressure portion and the surrounding environment. The negative pressure wound treatment system is configured to provide negative pressure to an area sealed by the bandage portion upon the actuation of the negative pressure portion. The negative pressure portion is configured to be actuated by compressing the negative pressure portion while walking.Type: ApplicationFiled: September 21, 2016Publication date: December 6, 2018Inventors: Julian Daich, Giorgio Giatsidis, Dennis P. Orgill
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Patent number: 9999691Abstract: The present invention provides methods for detecting an enzymatic activity, the method including combining at least one magnetic particle to an enzyme substrate to form a magnetically modified substrate, reacting the magnetically modified substrate with at least one enzyme; and detecting a change in a magnetic property of the magnetically modified substrate or its cleavage products, thereby detecting an activity of said at least one enzyme, wherein the method may be applied to a human subject to detect a disease selected from the group consisting of rheumatitis, arthritis, an injury, Dupuytren's disease, Peyronie's disease, a collagen related disease, steatosis, fibrosis, cirrhosis, metastasis, tissue regeneration, cancer, coronary disease, a liver disease, a metabolic condition, an infection and an inflammatory disease.Type: GrantFiled: December 25, 2013Date of Patent: June 19, 2018Inventor: Julian Daich
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Publication number: 20150174272Abstract: The invention relates to an implant or gel including at least one compound having magnetic functionality, which in turn includes a substrate of at least one enzyme involved in regenerating the extracellular matrix and a plurality of magnetic particles. The invention also relates to a compound having magnetic functionality which includes a substrate of at least one enzyme involved in regenerating the extracellular matrix and a plurality of magnetic particles, preferably with no coating or surface modification, or functionalised with carboxyl groups, for the production of an implant or gel for monitoring an enzyme activity involved in regenerating the extracellular matrix. The substrate is preferably selected from the group that comprises collagen, chondroitin sulphate and hyaluronic acid, and the magnetic particles are superparamagnetic particles.Type: ApplicationFiled: June 21, 2013Publication date: June 25, 2015Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)Inventors: Marisela Velez Tirado, Julián Daich
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Publication number: 20140162286Abstract: The present invention provides methods for detecting an enzymatic activity, the method including combining at least one magnetic particle to an enzyme substrate to form a magnetically modified substrate, reacting the magnetically modified substrate with at least one enzyme; and detecting a change in a magnetic property of the magnetically modified substrate or its cleavage products, thereby detecting an activity of said at least one enzyme, wherein the method may be applied to a human subject to detect a disease selected from the group consisting of rheumatitis, arthritis, an injury, Dupuytren's disease, Peyronie's disease, a collagen related disease, steatosis, fibrosis, cirrhosis, metastasis, tissue regeneration, cancer, coronary disease, a liver disease, a metabolic condition, an infection and an inflammatory disease.Type: ApplicationFiled: December 25, 2013Publication date: June 12, 2014Inventor: Julian DAICH
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Patent number: 8485984Abstract: An automatic breath collecting and sampling system, which is preferably carried by the subject, or otherwise kept with him or near him, for the recommended duration of the collection period. The system collects samples in separate switchable containers, either at predetermined time intervals, or in response to an automatic stimulus, which could be related to the breath content itself, or to another physiological signal, such as the subject s pulse rate, breath rate, blood pressure, or temperature, or in response to a signal related to an environmental effect, such as the presence of a strong concentration in the air of a foreign gas, which could be detected by an electrochemical sensor, or manually by the subject after being prompted by the system. After collection of the requisite number of separate containers, they may be detached and sent for analysis or other treatment.Type: GrantFiled: March 3, 2003Date of Patent: July 16, 2013Assignee: Exalenz Bioscience Ltd.Inventors: Boaz Giron, Julian Daich, Ilan Ben-Oren
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Patent number: 8469899Abstract: The present invention relates to the field of methods and apparatus for the determination of various conditions of gastric and gastro-intestinal malfunction, especially those performed by means of breath tests.Type: GrantFiled: March 3, 2008Date of Patent: June 25, 2013Assignee: Exalenz Bioscience Ltd.Inventors: Ilan Ben Oren, Julian Daich, Ephraim Carlebach, George Yariv
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Publication number: 20110182815Abstract: The present invention provides methods for detecting an enzymatic activity, the method including combining at least one magnetic particle to an enzyme substrate to form a magnetically modified substrate, reacting the magnetically modified substrate with at least one enzyme; and detecting a change in a magnetic property of the magnetically modified substrate or its cleavage products, thereby detecting an activity of said at least one enzyme, wherein the method may be applied to a human subject to detect a disease selected from the group consisting of rheumatitis, arthritis, an injury, Dupuytren's disease, Peyronie's disease, a collagen related disease, steatosis, fibrosis, cirrhosis, metastasis, tissue regeneration, cancer, coronary disease, a liver disease, a metabolic condition, an infection and an inflammatory disease.Type: ApplicationFiled: January 20, 2011Publication date: July 28, 2011Inventor: JULIAN DAICH
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Patent number: 7867171Abstract: Methods of determining gastro-intestinal conditions by performing a succession of breath tests or others tests, particularly for determining the gastric emptying or gastric accomodation condition of a subject. Methods of performing successive gastric emptying tests with different test meals are also presented, enabling the gastric accommodation to be determined. The effects of different test means on the results is presented. Novel substrates for use in such tests are suggested, including the use of micro-encapsulation. Breath tests for the detection of bacterial overgrowth, lactose intolerance and combinations thereof are presented.Type: GrantFiled: February 20, 2004Date of Patent: January 11, 2011Assignee: Exalenz Bioscience Ltd.Inventors: Ilan Ben-Oren, Julian Daich, Ephraim Carlebach, George Yariv
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Patent number: 7488229Abstract: Breath test methods and apparatus for increasing accuracy and reducing the time taken to achieve diagnostically useful results. In order to determine when an increase in isotopic ratio of the exhaled breath is clinically significant, methods are described for the use of a variable and multiple threshold level; for reducing the time taken to determine an accurate baseline level; and for avoiding the effects of oral activity when making measurements. To increase measurement accuracy, methods are described, using the results of the breath tests themselves, of continuous and automatic self-calibration to correct for drifts in the gas spectrometer absorption curves. A method for increasing the spectral stability of cold cathode discharge infra-red light sources for use in breath test instrumentation is described. Calibration checking devices and methods of mandating their use at regular time intervals are described, to ensure maintenance of the accuracy of breath tests.Type: GrantFiled: June 10, 2003Date of Patent: February 10, 2009Assignee: Oridion Medical (1987) Ltd.Inventors: Ilan Ben-Oren, Ephraim Carlebach, Julian Daich, Lewis Colman, Gershon Levitsky, Boaz Givron, Daniel Katzman
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Publication number: 20080281193Abstract: The present invention relates to the field of methods and apparatus for the determination of various conditions of gastric and gastro-intestinal malfunction, especially those performed by means of breath tests.Type: ApplicationFiled: March 3, 2008Publication date: November 13, 2008Inventors: Ilan BEN OREN, Julian Daich, Ephraim Carlebach, George Yariv
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Patent number: 7338444Abstract: The present invention relates to the field of methods and apparatus for the determination of various conditions of gastric and gastro-intestinal malfunction, especially those performed by means of breath tests.Type: GrantFiled: March 6, 2003Date of Patent: March 4, 2008Assignee: Oridion Breathid LtdInventors: Ilan Ben-Oren, Julian Daich, Ephraim Carlebach, George Yariv
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Publication number: 20060074335Abstract: The present invention relates to the field of methods and apparatus for the determination of various conditions of gastric and gastro-intestinal malfunction, especially those performed by means of breath tests.Type: ApplicationFiled: March 6, 2003Publication date: April 6, 2006Inventors: Ilan Ben-Oren, Julian Daich, Ephraim Calebach, George Yariv
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Publication number: 20050177056Abstract: An automatic breath collecting and sampling system, which is preferably carried by the subject, or otherwise kept with him or near him, for the recommended duration of the collection period. The system collects samples in separate switchable containers, either at predetermined time intervals, or in response to an automatic stimulus, which could be related to the breath content itself, or to another physiological signal, such as the subject s pulse rate, breath rate, blood pressure, or temperature, or in response to a signal related to an environmental effect, such as the presence of a strong concentration in the air of a foreign gas, which could be detected by an electrochemical sensor, or manually by the subject after being prompted by the system. After collection of the requisite number of separate containers, they may be detached and sent for analysis or other treatment.Type: ApplicationFiled: March 3, 2003Publication date: August 11, 2005Applicant: ORIDION BREATHID LTDInventors: Boaz Giron, Julian Daich, Ilan Ben-Oren
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Publication number: 20050020931Abstract: Methods of determining gastro-intestinal conditions by performing a succession of breath tests or others tests, particularly for determining the gastric emptying or gastric accomodation condition of a subject. Methods of performing successive gastric emptying tests with different test meals are also presented, enabling the gastric accommodation to be determined. The effects of different test means on the results is presented. Novel substrates for use in such tests are suggested, including the use of micro-encapsulation. Breath tests for the detection of bacterial overgrowth, lactose intolerance and combinations thereof are presented.Type: ApplicationFiled: February 20, 2004Publication date: January 27, 2005Applicant: Oridion Breathid Ltd.Inventors: Ilan Ben-Oren, Julian Daich, Ephraim Carlebach, George Yariv
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Patent number: 6656127Abstract: Breath test methods and apparatus for increasing accuracy and reducing the time taken to achieve diagnostically useful results. In order to determine when an increase in isotopic ratio of the exhaled breath is clinically significant, methods are described for the use of a variable and multiple threshold level; for reducing the time taken to determine an accurate baseline level; and for avoiding the effects of oral activity when making measurements. To increase measurement accuracy, methods are described, using the results of the breath tests themselves, of continuous and automatic self-calibration to correct for drifts in the gas spectrometer absorption curves. A method for increasing the spectral stability of cold cathode discharge infra-red light sources for use in breath test instrumentation is described. Calibration checking devices and methods of mandating their use at regular time intervals are described, to ensure maintenance of the accuracy of breath tests.Type: GrantFiled: April 4, 2000Date of Patent: December 2, 2003Assignee: Oridion Breathid Ltd.Inventors: Ilan Ben-Oren, Ephraim Carlebach, Julian Daich, Lewis Colman, Gershon Levitsky, Boaz Givron, Daniel Katzman
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Publication number: 20030216660Abstract: Breath test methods and apparatus for increasing accuracy and reducing the time taken to achieve diagnostically useful results. In order to determine when an increase in isotopic ratio of the exhaled breath is clinically significant, methods are described for the use of a variable and multiple threshold level; for reducing the time taken to determine an accurate baseline level; and for avoiding the effects of oral activity when making measurements. To increase measurement accuracy, methods are described, using the results of the breath tests themselves, of continuous and automatic self-calibration to correct for drifts in the gas spectrometer absorption curves. A method for increasing the spectral stability of cold cathode discharge infra-red light sources for use in breath test instrumentation is described. Calibration checking devices and methods of mandating their use at regular time intervals are described, to ensure maintenance of the accuracy of breath tests.Type: ApplicationFiled: June 10, 2003Publication date: November 20, 2003Inventors: Ilan Ben-Oren, Ephraim Carlebach, Julian Daich, Lewis Colman, Gershon Levitsky, Boaz Givron, Daniel Katzman