Patents by Inventor Julian Garcia-Rafanell

Julian Garcia-Rafanell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 2-hydroxy or 2-acetyloxy-4-trifluoromethylbenzoic acid derivatives as an agent for the treatment and prevention of mild cognitive impairment
    Publication number: 20030162756
    Abstract: The present invention relates to the use of 2-hydroxy or 2-acetyloxy-4-trifluoromethylbenzoic acid, respectively, for the treatment or prevention of mild cognitive impairment (MCI) in mammals, especially in human beings. Futhermore, the present invention also concerns the use of 2-hydroxy or 2-acetyloxy-4-trifluoromethylbenzoic acid, respectively, for delaying or preventing the conversion of MCI into dementia, especially Alzheimer's Disease.
    Type: Application
    Filed: December 6, 2002
    Publication date: August 28, 2003
    Applicant: J. Uriach & CIA. S.A.
    Inventors: Julian Garcia-Rafanell, Genis Munoz Orti, Jose Carlos Navas Ramirez, Jose Ignacio Izquierdo Pulido
  • Use of 2-hydroxy-4-trifluoromethyl-benzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-KS
    Patent number: 6610745
    Abstract: Neurodegenerative diseases, such as dementia, including Alzheimer's disease, can be treated or prevented by administering an effective amount of triflusal or its metabolite, or a pharmaceutically acceptable salt or a prodrug thereof.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: August 26, 2003
    Assignee: J. Uriach & Cia, S.A.
    Inventors: Manuel Merlos Roca, Alberto Fernandez De Arriba, Fernando Cavalcanti De Maria, Agustí Miralles Acosta, Mariano Sanchez Crespo, Julián Garcia Rafanell, Javier Forn Dalmau
  • Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-kappaB
    Publication number: 20030032630
    Abstract: Neurodegenerative diseases, such as dementia, including Alzheimer's disease, can be treated or prevented by administering an effective amount of triflusal or its metabolite, or a pharmaceutically acceptable salt or a prodrug thereof.
    Type: Application
    Filed: April 4, 2002
    Publication date: February 13, 2003
    Inventors: Manuel Merlos Roca, Alberto Fernandez De Arriba, Fernando Cavalcanti De Maria, Agusti Miralles Acosta, Mariano Sanchez Crespo, Julian Garcia Rafanell, Javier Forn Dalmau
  • Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-&kgr;B
    Patent number: 6509377
    Abstract: A method for inhibiting the activation of transcription factor NF-&kgr;B in a warm-blooded animal in need thereof, comprises administering to said animal an effective amount of a compound of formula I wherein R represents hydrogen or COCH3, or a pharmaceutically acceptable salt or a prodrug thereof.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: January 21, 2003
    Assignee: J. Uriach & Cia, S.A.
    Inventors: Manuel Merlos Roca, Alberto Fernandez De Arriba, Fernando Cavalcanti De Maria, Agustí Miralles Acosta, Mariano Sanchez Crespo, Julián Garcia Rafanell, Javier Forn Dalmau
  • Utilization of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factors NF-&kgr;&bgr;
    Patent number: 6414025
    Abstract: The invention relates to the use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-&kgr;B. The invention also relates to the utilization of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives for the preparation of medicaments to treat or prevent of pathologies associated to the activation of NF-&kgr;B and/or the expression of genes which are dependent on or regulated by, at least partially, NF&kgr;B in mammals, including humans.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: July 2, 2002
    Assignee: J. Uriach & Cia, S.A.
    Inventors: Manuel Merlos Roca, Alberto Fernandez De Arriba, Fernando Cavalcanti De Maria, Agustí Miralles Acosta, Mariano Sanchez Crespo, Julián Garcia Rafanell, Javier Forn Dalmau
  • Azo derivatives of 5-aminosalicylic acid
    Patent number: 5747477
    Abstract: Compounds of formula I and their salts and solvates are useful for the treatment or prevention of inflammatory bowel disease. Pharmaceutical compositions including these compounds and processes for their preparation are also provided.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: May 5, 1998
    Assignee: J. Uriach & Cia S.A.
    Inventors: Elena Carceller, Pere J. Jimenez, Jordi Salas, Carmen Almansa, Javier Bartroli, Manel Merlos, Marta Giral, Dolors Balsa, Rosa Ferrando, Julian Garcia-Rafanell, Javier Forn
  • Treatment of PAF and histamine-mediated diseases with 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydr o-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
    Patent number: 5476856
    Abstract: The present invention relates to 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine, to a process for its preparation and to pharmaceutical compositions containing it. This compound is a dual PAF antagonist and antihistamine.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: December 19, 1995
    Assignee: J. Uriach & Cia. S.A.
    Inventors: Elena Carceller, Nuria Recasens, Carmen Almansa, Javier Bartroli, Manel Merlos, Marta Giral, Julian Garcia-Rafanell, Javier Forn
  • 8-chloro-11-[1-[(5-methy l-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1 ,]pyridine
    Patent number: 5407941
    Abstract: The present invention relates to 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine, to a process for its preparation and to pharmaceutical compositions containing it. This compound is a dual PAF antagonist and antihistamine.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: April 18, 1995
    Assignee: J. Uriach & Cia. S.A.
    Inventors: Elena Carceller, Nuria Recasens, Carmen Almansa, Javier Bartroli, Manel Merlos, Marta Giral, Julian Garcia-Rafanell, Javier Forn