Abstract: Examining genomic information for a specific variance, while useful, provides limited information. Accordingly, systems and methods are provided to analyze a subject's genome against a background population. Outlier variances that are known ontological terms having at least a threshold strength-of-effect are then determined between each member. As a benefit, the subject's outlier variances, which may be further ranked in terms of relationship to a known phenotype, may be identified for an entirety or portion of a genomic sequence.

Abstract: The invention relates to methods and compositions for converting one cell type to another cell type. Specifically, the invention relates to transdifferentiation of a cell to a different cell type. The invention relates to a method for determining the transcription factors required for conversion of a source cell to a cell exhibiting at least one characteristic of a target cell type. The invention also relates to method of reprogramming or forward programming a source cell.

Abstract: The present invention relates to methods and compositions, including kits for reprogramming a source cell to a cardiomyocyte, the method comprising increasing the protein expression of one or more transcription factors, or variants thereof, in the source cell, wherein the source cell is reprogrammed to exhibit at least one characteristic of a cardiomyocyte.

Abstract: Examining genomic information for a specific variance, while useful, provides limited information. Accordingly, systems and methods are provided to analyze a subject's genome against a background population. Outlier variances that are known ontological terms having at least a threshold strength-of-effect are then determined between each member.

Abstract: The present invention relates to methods and compositions for reprogramming a source cell to produce a chondrocyte, the method comprising activating or increasing the protein expression of one or more transcription factors, or variants thereof, in the source cell.

Abstract: A weight sensor may include a weighing platform and a load cell coupled to the platform to sense a weight applied to the platform, the load cell may include a deformable plate with one or more strain gauges arranged to provide an electrical signal representing the weight applied to the platform, and a base supporting the load cell, wherein the deformable plate is movably mounted to the base at only three contact points, the contact points allowing lateral movement of the plate when the plate deforms in response to a weight applied to the platform. The weight sensor makes it possible to monitor the weight and weight shifting of two people sharing the bed. The weight sensor is self-centering when a load is applied off-center to the platform, which is beneficial when used underneath a bed, e.g., under a bed leg or other support member which may not be aligned.

Abstract: The invention relates to methods and compositions for converting one cell type to another cell type. Specifically, the invention relates to transdifferentiation of a cell to a different cell type. The invention relates to a method for determining the transcription factors required for conversion of a source cell to a cell exhibiting at least one characteristic of a target cell type. The invention also relates to method of reprogramming or forward programming a source cell.

Abstract: A weight sensor may include a weighing platform and a load cell coupled to the platform to sense a weight applied to the platform, the load cell may include a deformable plate with one or more strain gauges arranged to provide an electrical signal representing the weight applied to the platform, and a base supporting the load cell, wherein the deformable plate is movably mounted to the base at only three contact points, the contact points allowing lateral movement of the plate when the plate deforms in response to a weight applied to the platform. The weight sensor makes it possible to monitor the weight and weight shifting of two people sharing the bed. The weight sensor is self-centering when a load is applied off-center to the platform, which is beneficial when used underneath a bed, e.g., under a bed leg or other support member which may not be aligned.

Abstract: A weight sensor may include a weighing platform and a load cell coupled to the platform to sense a weight applied to the platform. The load cell may include a deformable plate with one or more strain gauges arranged to provide an electrical signal representing the weight applied to the platform, and a base supporting the load cell, wherein the deformable plate is movably mounted to the base at only three contact points, the contact points allowing lateral movement of the plate relative to the base when the plate deforms in response to a weight applied to the platform. The weight sensor makes it possible to independently monitor the weight and weight shifting of two people sharing the same bed. The weight sensor is self-centering when a load is applied off-center to the platform, which is particularly beneficial when such a weight sensor is used underneath a bed, e.g., under a bed leg or other support member which may not be aligned centrally over the weight sensor.

Abstract: A weight sensor may include a weighing platform and a load cell coupled to the platform to sense a weight applied to the platform. The load cell may include a deformable plate with one or more strain gauges arranged to provide an electrical signal representing the weight applied to the platform, and a base supporting the load cell, wherein the deformable plate is movably mounted to the base at only three contact points, the contact points allowing lateral movement of the plate relative to the base when the plate deforms in response to a weight applied to the platform. The weight sensor makes it possible to independently monitor the weight and weight shifting of two people sharing the same bed. The weight sensor is self-centering when a load is applied off-centre to the platform, which is particularly beneficial when such a weight sensor is used underneath a bed, e.g., under a bed leg or other support member which may not be aligned centrally over the weight sensor.