Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).

Abstract: The present invention relates to methods and devices for evacuating the contents of a primary waste vessel to a secondary waste vessel, desirably between production runs of an automated synthesis device.

Abstract: The present invention relates to improved 18F-labelled aldehyde compositions, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are methods of preparation of radiofluorinated biological targeting molecules using said improved compositions, together with radiopharmaceutical compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.

Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.

Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.

Abstract: The present invention relates to a method of purification of [18F]-fluciclatide via solid phase extraction (SPE). The method is amenable to automation, and is suitable for use in conjunction with automated synthesizer apparatus—especially cassette-based synthesizers. Also provided are cassettes for carrying out the purification method.

Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.

Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).

Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).

Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.

Abstract: The invention describes a method for stripping alumina which is particularly suitable for removal of fluoride from alumina and comprises washing said alumina with an aqueous acid or alkali at elevated temperature. The method may be used for removal of unreacted radiofluoride such as [18F]fluoride from alumina following a radiofluorination reaction. Automated synthesis apparatus and cassettes therefor, which are adapted to perform the method are also claimed.

Abstract: The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the deprotected product are carried out by the addition of a neutralisation agent. The deprotected product is buffered in a pH range suitable for subsequent autoclaving and formulation into an injectable radiopharmaceutical.

Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.

Abstract: The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent.

Abstract: The invention describes a method for stripping alumina which is particularly suitable for removal of fluoride from alumina and comprises washing said alumina with an aqueous acid or alkali at elevated temperature. The method may be used for removal of unreacted radiofluoride such as [18F]fluoride from alumina following a radiofluorination reaction. Automated synthesis apparatus and cassettes therefor, which are adapted to perform the method are also claimed.

Abstract: The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the deprotected product are carried out by the addition of a neutralisation agent. The deprotected product is buffered in a pH range suitable for subsequent autoclaving and formulation into an injectable radiopharmaceutical.

Abstract: A fire or explosion suppression system comprises a source (30) of a liquid suppressant under pressure, and a source (32) of an inert gas under pressure. The liquid suppressant is a chemical substance having a low environmental impact, with a short atmospheric lifetime of less than 30 days. The inert gas may be nitrogen, carbon dioxide, argon, neon or helium or mixtures of any two or more of them. The suppressant and the inert gas are fed under pressure to an output unit (34) comprising a mixing chamber in which the liquid and the gas impinge to produce a mist of the liquid suppressant of very small droplet size which is entrained in the pressurised gas together with vapour from the liquid, the so-entrained mist and vapour and the gas being discharged by a nozzle (44) into an area to be protected. The mist and vapour are therefore carried by the entraining and transporting high pressure gas into regions of the areas to be protected, enabling a total flooding capability.

Abstract: A fire or explosion suppression system comprises a source (30) of a liquid suppressant under pressure, and a source (32) of an inert gas under pressure. The liquid suppressant is a chemical substance having a low environmental impact, with a short atmospheric lifetime of less than 30 days. The inert gas may be nitrogen, carbon dioxide, argon, neon or helium or mixtures of any two or more of them. The suppressant and the inert gas are fed under pressure to an output unit (34) comprising a mixing chamber in which the liquid and the gas impinge to produce a mist of the liquid suppressant of very small droplet size which is entrained in the pressurised gas together with vapour from the liquid, the so-entrained mist and vapour and the gas being discharged by a nozzle (44) into an area to be protected. The mist and vapour are therefore carried by the entraining and transporting high pressure gas into regions of the areas to be protected, enabling a total flooding capability.

Abstract: A fire and explosion suppression system comprises a source (5) of high pressure water which is fed to a misting nozzle (13) or other water mist generating means at one input of a mixing unit (6), and a source (14) of high pressure inert gas, such as nitrogen, which is fed along a pipe (20) to another input of the mixing unit (6). Inside the mixing unit (6), water mist, in the form of an atomised mist of very small droplet size is mixed with the pressurised gas and exits the mixing unit (6) at high pressure and high velocity along a pipe (22) and is thence discharged through spreaders (26, 28). Separation of the mist production from the actual discharge of the mist, and the entraining and transporting of the mist between these two stages at high pressure and high velocity, produces an output mist of very small droplet size which is carried by the entraining and transporting high pressure gas into the area to be protected, enabling a total flooding capability.

Abstract: A fire or explosion suppression system comprises a source (30) of a liquid suppressant under pressure, and a source (32) of an inert gas under pressure. The liquid suppressant is a chemical substance having a low environmental impact, with a short atmospheric lifetime of less than 30 days. The inert gas may be nitrogen, carbon dioxide, argon, neon or helium or mixtures of any two or more of them. The suppressant and the inert gas are fed under pressure to an output unit (34) comprising a mixing chamber in which the liquid and the gas impinge to produce a mist of the liquid suppressant of very small droplet size which is entrained in the pressurised gas together with vapour from the liquid, the so-entrained mist and vapour and the gas being discharged by a nozzle (44) into an area to be protected. The mist and vapour are therefore carried by the entraining and transporting high pressure gas into regions of the areas to be protected, enabling a total flooding capability.