Patents by Inventor Julian Jazayeri
Julian Jazayeri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11938304Abstract: Impact testing apparatuses are disclosed which simulate and measure various impact-related events associated with the operation of a drug delivery device. The impact testing apparatus may include an impactor configured to simulate a plunger rod of the drug delivery device, and a guide sleeve configured to receive a syringe corresponding to the drug delivery device. The syringe may have a proximal end, a distal end defining an outlet, and an interior chamber extending between the proximal and distal ends and carrying a plunger. Additionally, the impact testing apparatus may include an energy source configured to reduce a distance between the impactor and the plunger so that the impactor strikes the plunger. Various sensors may be included to measure characteristics of one or more impacts caused by the impactor. Methods of impact testing a syringe filled with a fluid and carrying a plunger are also disclosed.Type: GrantFiled: November 30, 2022Date of Patent: March 26, 2024Assignee: AMGEN INC.Inventors: Julian Jazayeri, Sean Fitzgibbon, Joshua Tamsky, Christopher R. Folk
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Publication number: 20230105242Abstract: Impact testing apparatuses are disclosed which simulate and measure various impact-related events associated with the operation of a drug delivery device. The impact testing apparatus may include an impactor configured to simulate a plunger rod of the drug delivery device, and a guide sleeve configured to receive a syringe corresponding to the drug delivery device. The syringe may have a proximal end, a distal end defining an outlet, and an interior chamber extending between the proximal and distal ends and carrying a plunger. Additionally, the impact testing apparatus may include an energy source configured to reduce a distance between the impactor and the plunger so that the impactor strikes the plunger. Various sensors may be included to measure characteristics of one or more impacts caused by the impactor. Methods of impact testing a syringe filled with a fluid and carrying a plunger are also disclosed.Type: ApplicationFiled: November 30, 2022Publication date: April 6, 2023Inventors: Julian Jazayeri, Sean Fitzgibbon, Joshua Tamsky, Christopher R. Folk
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Patent number: 11541176Abstract: Impact testing apparatuses are disclosed which simulate and measure various impact-related events associated with the operation of a drug delivery device. The impact testing apparatus may include an impactor configured to simulate a plunger rod of the drug delivery device, and a guide sleeve configured to receive a syringe corresponding to the drug delivery device. The syringe may have a proximal end, a distal end defining an outlet, and an interior chamber extending between the proximal and distal ends and carrying a plunger. Additionally, the impact testing apparatus may include an energy source configured to reduce a distance between the impactor and the plunger so that the impactor strikes the plunger. Various sensors may be included to measure characteristics of one or more impacts caused by the impactor. Methods of impact testing a syringe filled with a fluid and carrying a plunger are also disclosed.Type: GrantFiled: May 8, 2017Date of Patent: January 3, 2023Assignee: AMGEN INC.Inventors: Julian Jazayeri, Sean Fitzgibbon, Joshua Tamsky, Christopher R. Folk
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Publication number: 20220207111Abstract: A method for determining predicted failure rates of drug injection devices includes receiving a set of parameters specifying physical properties of a syringe, a liquid drug, and a drug injection device configured to deliver the liquid drug to a patient via the syringe, the drug injection device including a mechanism that drives a plunger rod toward a plunger of the syringe encased in a syringe carrier. The method also includes receiving failure rate data specifying a measured rate of failure of the drug injection device in response to various peak pressures within the syringe, applying the set of parameters to a kinematic model of the drug injection device to determine a predicted peak pressure within the syringe, determining a probability of failure of the drug injection device using the failure rate data and predicted peak pressure, and providing an indication of the determined probability of failure to an output device.Type: ApplicationFiled: November 8, 2021Publication date: June 30, 2022Inventors: Sean Fitzgibbon, Christopher R. Folk, Julian Jazayeri
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Publication number: 20220184318Abstract: A cassette for a drug delivery device is described that includes a sleeve, a syringe having a barrel disposed in the sleeve, and a plunger-stopper slidably disposed within the barrel. An end cap is adapted to couple to the sleeve to secure the syringe in the sleeve. The cassette further includes a spacer that is sized to be slidably moved within the barrel and the spacer is disposed distal to the plunger-stopper to be engaged by a plunger rod to slide within the barrel and engage the plunger-stopper. In some forms, the spacer can be coupled to the end cap.Type: ApplicationFiled: April 10, 2020Publication date: June 16, 2022Inventors: Azita Rahbari, Sunitha Dasoju, Angelo Tosarini, Antonio Antonini, Julian Jazayeri, Harpreet Sachar, Andrew Coles, Desheng Yin, Alireza Ashani
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Patent number: 11285266Abstract: A drug delivery device includes a reservoir, a drug delivery member in fluid communication with the reservoir, and a plunger disposed in and moveable relative to the reservoir. A plunger rod has a mass MP and is movable from (i) a first position, where the distal end of the plunger rod is spaced apart from the plunger to (ii) a second position, where the distal end of the plunger rod contacts the plunger. A drive mechanism is coupled to the proximal end of the plunger rod and is configured to deliver a drive force FD to move the plunger rod from the first position to the second position. A ratio of the mass of the plunger rod to the drive force of the drive mechanism (MP/FD) is in a range of approximately a value greater than 0 kg/kgf to approximately 0.05 kg/kgf.Type: GrantFiled: May 15, 2017Date of Patent: March 29, 2022Assignee: AMGEN INC.Inventors: Sean Fitzgibbon, Julian Jazayeri
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Publication number: 20220047815Abstract: A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.Type: ApplicationFiled: October 29, 2021Publication date: February 17, 2022Inventors: Julian Jazayeri, Ronald Forster, Jolita Seckute, Olivia Alice Henderson, Kristen Brown, Gregory Gordon, Rasmus Ohlenschlaeger, Peter Dan Kaare Soelberg
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Patent number: 11200298Abstract: A method for determining predicted failure rates of drug injection devices includes receiving a set of parameters that specify physical properties of (i) a syringe, and (ii) a liquid drug, and (iii) a drug injection device configured to deliver the liquid drug to a patient via the syringe. The method further includes receiving failure rate data that specifies a measured rate of failure of the drug injection device in response to various peak pressures within the syringe, applying the received set of parameters to a kinematic model of the drug injection device to determine a predicted peak pressure within the syringe, including determining the predicted peak pressure as a function of impact velocity of the liquid drug, determining a probability of failure of the drug injection device using (i) the received failure rate data and (ii) the predicted peak pressure, and providing an indication of the determined probability of failure to an output device.Type: GrantFiled: March 14, 2017Date of Patent: December 14, 2021Assignee: AMGEN INC.Inventors: Sean Fitzgibbon, Christopher R. Folk, Julian Jazayeri
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Patent number: 11191904Abstract: A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.Type: GrantFiled: October 9, 2018Date of Patent: December 7, 2021Assignee: AMGEN INC.Inventors: Julian Jazayeri, Ronald Forster, Jolita Seckute, Olivia Alice Henderson, Kristen Brown, Gregory Gordon, Rasmus Øhlenschlæger, Peter Dan Kaare Soelberg
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Publication number: 20200338269Abstract: Impact testing apparatuses are disclosed which simulate and measure various impact-related events associated with the operation of a drug delivery device. The impact testing apparatus may include an impactor configured to simulate a plunger rod of the drug delivery device, and a guide sleeve configured to receive a syringe corresponding to the drug delivery device. The syringe may have a proximal end, a distal end defining an outlet, and an interior chamber extending between the proximal and distal ends and carrying a plunger. Additionally, the impact testing apparatus may include an energy source configured to reduce a distance between the impactor and the plunger so that the impactor strikes the plunger. Various sensors may be included to measure characteristics of one or more impacts caused by the impactor. Methods of impact testing a syringe filled with a fluid and carrying a plunger are also disclosed.Type: ApplicationFiled: May 8, 2017Publication date: October 29, 2020Inventors: Julian Jazayeri, Sean Filzgibbon, Joshua Tamsky, Christopher R. Folk
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Publication number: 20200114082Abstract: A drug delivery device includes a housing defining a shell having a proximal and a distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing, and a damper mechanism at least partially disposed within the housing adjacent to the distal end. The housing further defines a longitudinal axis extending between the proximal end and the distal end. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. The drive assembly is operably coupled to the needle assembly to urge the medicament through the needle or cannula. The damper mechanism is operably coupled to the drive assembly and the housing. Upon activating the drive assembly, the damper mechanism dampens an effect thereof.Type: ApplicationFiled: October 15, 2019Publication date: April 16, 2020Inventors: Matias Melander, Jakob Halkjaer Pedersen, Christian Plambech, Adam B. McCullough, Julian Jazayeri
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Publication number: 20190167908Abstract: Components of drug delivery devices can experience large impact forces by a spring-loaded drive mechanism causing a drug reservoir of the delivery device to fracture. For an autoinjector having a reservoir, a plunger rod, a drive mechanism, and a carrier that experiences two impact events when the autoinjector is activated, the mass of the carrier and the mass of the rod is increased by a mass multiplier to reduce the impact pressure at both first and second impacts. The internal pressure of the device decreases in relation to a mass of the impact system 110 to force ratio, where the force is the drive force of the drive mechanism. To reduce the impact pressure from the first event, the mass of the plunger rod may be increased within a range such that the ratio of plunger rod mass to drive force is within a range of approximately a value greater than 0 kg/kgf to approximately 0.05 kg/kgf.Type: ApplicationFiled: May 15, 2017Publication date: June 6, 2019Applicant: AMGEN INC.Inventors: Sean Fitzgibbon, Julian Jazayeri
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Publication number: 20190143047Abstract: A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.Type: ApplicationFiled: October 9, 2018Publication date: May 16, 2019Inventors: Julian Jazayeri, Ronald Forster, Jolita Seckute, Olivia Alice Henderson, Kristen Brown, Gregory Gordon, Rasmus Øhlenschlæger, Peter Dan Kaare Soelberg
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Publication number: 20190050375Abstract: A method for determining predicted failure rates of drug injection devices includes receiving a set of parameters that specify physical properties of (i) a syringe, and (ii) a liquid drug, and (iii) a drug injection device configured to deliver the liquid drug to a patient via the syringe. The method further includes receiving failure rate data that specifies a measured rate of failure of the drug injection device in response to various peak pressures within the syringe, applying the received set of parameters to a kinematic model of the drug injection device to determine a predicted peak pressure within the syringe, including determining the predicted peak pressure as a function of impact velocity of the liquid drug, determining a probability of failure of the drug injection device using (i) the received failure rate data and (ii) the predicted peak pressure, and providing an indication of the determined probability of failure to an output device.Type: ApplicationFiled: March 14, 2017Publication date: February 14, 2019Inventors: Sean Fitzgibbon, Christopher R. Folk, Julian Jazayeri