Patents by Inventor Julian KRETZ

Julian KRETZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
    Patent number: 11655243
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2 and R1-R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: May 23, 2023
    Assignees: HOFFMANN-LA ROCHE INC., EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
    Inventors: Simon M. Ametamey, Kenneth Atz, Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz
  • NOVEL AZETIDINE-SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2
    Publication number: 20210130334
    Abstract: The invention relates to a compound of formula (I) wherein A1 and R1-R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 17, 2020
    Publication date: May 6, 2021
    Applicants: HOFFMANN-LA ROCHE INC., EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
    Inventors: Simon M. Ametamey, Luca Gobbi, Uwe Grether, Julian Kretz
  • RADIOLABELED CANNABINOID RECEPTOR 2 LIGAND
    Publication number: 20210115012
    Abstract: The present invention relates to a compound of formula (I) wherein R1, R2, and R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a radiolabeled ligand.
    Type: Application
    Filed: December 17, 2020
    Publication date: April 22, 2021
    Applicants: HOFFMANN-LA ROCHE INC., ETH ZUERICH
    Inventors: Simon M. Ametamey, Luca Gobbi, Uwe Grether, Julian Kretz, Dieter Muri, Ahmed Haider Wahauib
  • PYRIDINE AND PYRAZINE DERIVATIVES AS PREFERENTIAL CANNABINOID 2 AGONISTS
    Publication number: 20210115027
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2 and R1-R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 17, 2020
    Publication date: April 22, 2021
    Applicants: HOFFMANN-LA ROCHE INC., EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
    Inventors: Simon M. Ametamey, Kenneth Atz, Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz
  • NOVEL PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2
    Publication number: 20210115011
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2, X and R1-R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 17, 2020
    Publication date: April 22, 2021
    Applicants: HOFFMANN-LA ROCHE INC., ETH ZUERICH
    Inventors: Luca Gobbi, Uwe Grether, Julian Kretz, Simon M. Ametamey
  • [1,2,3]triazolo[4,5-d]pyrimidine derivatives
    Patent number: 10457684
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 29, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal
  • [1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
    Patent number: 10457685
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 29, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal, Adriaan Pieter Ijzerman
  • [1,2,3]triazolo[4,5-D]pyrimidine derivatives
    Patent number: 10457686
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 29, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal
  • [1,2,3]triazolo[4,5-D]pyrimidine derivatives
    Patent number: 10450321
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 22, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal, Adriaan Pieter Ijzerman
  • Albicidin derivatives, their use and synthesis
    Patent number: 10308595
    Abstract: Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: June 4, 2019
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Roderich Suessmuth, Julian Kretz, Vivien Schubert, Alexander Pesic, Manuela Huegelland, Monique Royer, Stephane Cociancich, Philippe Rott, Dennis Kerwat, Stefan Graetz
  • NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
    Publication number: 20190127386
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Luca GOBBI, Uwe GRETHER, Wolfgang GUBA, Julian KRETZ, Rainer E. MARTIN, Matthias Valentin WESTPHAL
  • [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RECEPTOR
    Publication number: 20190127384
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Luca GOBBI, Uwe GRETHER, Wolfgang GUBA, Julian KRETZ, Rainer E. MARTIN, Matthias Valentin WESTPHAL, Adriaan Pieter IJZERMAN
  • NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
    Publication number: 20190127385
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer E. Martin, Matthias Valentin Westphal, Adriaan Pieter Ijzerman
  • NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
    Publication number: 20190127383
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Luca GOBBI, Uwe Grether, Wolfgang Guba, Julian Kretz, Rainer Martin, Matthias Valentin Westphal
  • ALBICIDIN DERIVATIVES, THEIR USE AND SYNTHESIS
    Publication number: 20150376120
    Abstract: Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.
    Type: Application
    Filed: February 14, 2014
    Publication date: December 31, 2015
    Inventors: Roderich SÜSSMUTH, Julian KRETZ, Vivien SCHUBERT, Alexander PESIC, Manuela HÜGELLAND, Monique ROYER, Stéphane COCIANCICH, Philippe ROTT, Dennis KERWAT, Stefan GRÄTZ