Abstract: An Internet-based competitive pricing and bidding transaction system includes one or more transaction processing servers that interface and communicate over the Internet with client computer systems of prospective online consumers, medical and professional/licensed services providers and a plurality of related information databases. The transaction processing system handles online communications and procedures for conducting auctions for delivery of proffered medical and professional/licensed services and maintains a registration database of service providers and online prospective consumers/bidders. Medical and professional/licensed services providers may include licensed doctors/nurses, licensed veterinary doctors/technicians as well as conventional homecare/hospice providers, physical therapy providers, babysitting and other professional caretaker services that can provided to/for man or animal.

Abstract: Transactional costs associated with providing professional services are reduced by allowing prospective patients/clients (bidders) and professional service providers to negotiate competitively for desired fees for proffered services through an interactive on-line communications network such as the Internet. In an exemplary arrangement, a transaction system includes a communications network server that interfaces and communicates online with client computer systems belonging to various prospective bidders and personal medical service providers using, for example, an exchange of HTML documents and/or JAVA script applets. A service feedback interface and database are provided for handling online feedback information and comments from patients/clients and providers regarding the complexity and quality of services received or provided. A procedure complexity rating value based on concurrent personal medical problems/pre-existing conditions known to the prospective patient is defined and posted online.

Abstract: An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

Abstract: A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail.

Abstract: A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail.

Abstract: The invention relates to systems and methods for treating a fungal infection of the nail of an individual. In various embodiments, the methods include applying a device to at least one nail of the individual that is infected by a fungus. In various embodiments, the devices include at least one active electrode and at least one counter electrode, with the at least one counter electrode in contact with the individual.

Abstract: Transactional costs associated with providing professional services are reduced by allowing prospective patients/clients (bidders) and professional service providers to negotiate competitively for desired fees for proffered services through an interactive on-line communications network such as the Internet. In an exemplary arrangement, a transaction system includes a communications network server that interfaces and communicates online with client computer systems belonging to various prospective bidders and personal medical service providers using, for example, an exchange of HTML documents and/or JAVA script applets. A transaction system server handles online communications and procedures for conducting auctions for delivery of proffered services and maintains a registration database of service providers and bidders. An authentication/qualifier engine automatically researches and verifies service provider credentials and background information upon registration of a service provider with the system.

Abstract: Transactional costs associated with providing professional services are reduced by allowing prospective patients/clients (bidders) and professional service providers to negotiate competitively for desired fees for proffered services through an interactive on-line communications network such as the Internet. In an exemplary arrangement, a transaction system includes a communications network server that interfaces and communicates online with client computer systems belonging to various prospective bidders and personal medical service providers using, for example, an exchange of HTML documents and/or JAVA script applets. A transaction system server handles online communications and procedures for conducting auctions for delivery of proffered services and maintains a registration database of service providers and bidders. An authentication/qualifier engine automatically researches and verifies service provider credentials and background information upon registration of a service provider with the system.

Abstract: Transactional costs associated with providing professional services are reduced by allowing prospective patients/clients (bidders) and professional service providers to negotiate competitively for desired fees for proffered services through an interactive on-line communications network such as the Internet. A transaction system server handles online communications and procedures for conducting auctions for delivery of proffered services and maintains a registration database of service providers and bidders. An authentication/qualifier engine automatically researches and verifies service provider credentials and background information upon registration of a service provider with the system. A service feedback interface and database are provided for handling online feedback information and comments from patients/clients and providers regarding the complexity and quality of services received or provided.

Abstract: A screening device that screens for the presence or absence of one or more substances in a mammalian body is disclosed. The device includes a plurality of electrodes, and a biosensor assembly having a reference region and at least one sensor region. The reference region includes at least one microneedle and microchannel, and each sensor region includes at least one microneedle and microchannel, and is sensitive to a specific substance. Each sensor microchannel in a respective sensor region includes a specific assay ligand that may bond with the particular substance to be sensed. Also disclosed is a method for the screening for the presence or absence of one or more substances in the mammalian body.

Abstract: Novel multichannel ionosonic devices with microneedle arrays incorporated into the devices for transdermal and intradermal delivery are described. In an embodiment, the ionosonic device includes a multichannel ionophoretic driver used in combination with a multichannel dispersion electrode integrated with ultrasonic elements and microneedle array elements mounted on a single application electrode. The ionosonic-microneedle transdermal device can be configured in a variety of shapes and structural flexibility for the treatment of skin and systemic disorders through the intradermal and transdermal delivery of one or more of a variety of therapeutic and modulating agents. Because of enhanced transdermal penetration this device offers the transdermal delivery of therapeutic peptides is getting closer to reality.

Abstract: A system for delivering a substance into a body at a treatment site that includes an alternating current source and a plurality of electrodes. Circuitry is connected between the alternating current source and the electrodes for supplying current to the electrodes when the electrodes are in electrical contact with said body so that a uni-directional current flow for delivering the substance into the body is maintained at the treatment site and a bi-directional current flow is maintained throughout the body. At least one of the electrodes is divided into sub-electrodes to, for example, reduce hazards associated with current concentration. These and other systems and methods are adaptable for large treatment areas and/or use a convenient and low-cost arrangement of electronics.

Abstract: An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site.

Abstract: An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

Abstract: A device for removing airborne contaminants and inhaled biopathogens, particularly particulate or aerosol contaminants, from respired air that can be either stationary or incorporated into a garment or accessory worn upon the body. In a preferred embodiment, a negative electrode is connected to voltage multiplier and modulation circuit and then to a discharge electrode having an electron emissive surface disposed near the wearer's airway. The positive (counter) electrode is similarly disposed away from the airway such as, for example, near the forehead. Electrons, ejected from the electron emissive surface, transfer a negative charge to airborne particulate contaminants which are accelerated toward, and collected by, the counter electrode.

Abstract: Non-reusable, medicament-dispensing applicator electrodes adapted for use with an iontophoresis device for facilitating delivery of medication across the cutaneous membrane into adjacent underlying tissues and blood vessels. The embodiments of the iontophoresis electrode include an open mesh having cells in the medicament dispensing portions of the electrode which retain a medicament in the form of liquid, gel or ointment. The cells are adapted to contain and iontophoretically dispense and deliver medicament formulations, which have been previously approved for therapeutic use by cognizant regulatory authorities obviating the need for reformulation. The medicament-dispensing electrodes are composite or unitary in construction and may be useful in the treatment of acne and also genital herpes simplex infection which produces cutaneous lesions, including lesions above and below the waist.

Abstract: An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source.

Abstract: An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site.

Abstract: An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

Abstract: An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site.