Patents by Inventor Julian M. Cortella
Julian M. Cortella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7050157Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.Type: GrantFiled: July 19, 2002Date of Patent: May 23, 2006Assignee: OptiScan Biomedical Corp.Inventors: James R. Braig, Peter Rule, Robert D. Gaffney, Philip C. Hartstein, Julian M. Cortella, Kenneth I. Li, Bernhard B. Sterling, Peng Zheng, W. Dale Hall, Kenneth G. Witte, Mark D. Agostino, Daniel S. Goldberger
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Patent number: 6958809Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.Type: GrantFiled: January 21, 2002Date of Patent: October 25, 2005Assignee: Optiscan Biomedical CorporationInventors: Bernhard B. Sterling, Philip C. Hartstein, Ken I. Li, Mark D. Agostino, David C. Klonoff, Robert D. Gaffney, Jennifer H. Gable, Ken G. Witte, Mike A. Munrow, Daniel S. Goldberger, Julian M. Cortella, James R. Braig, Peter Rule
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Patent number: 6959211Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.Type: GrantFiled: August 6, 2002Date of Patent: October 25, 2005Assignee: OptiScan Biomedical Corp.Inventors: Peter Rule, James R. Braig, Daniel S. Goldberger, Julian M. Cortella, Heidi M. Smith, Roger O. Herrera, Kenneth G. Witte, Philip C. Hartstein, Mark D. Agostino
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Patent number: 6931328Abstract: An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection system has a processor that calculates analyte concentration in accordance with software executable by the processor. Under certain conditions, the software needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.Type: GrantFiled: November 8, 2002Date of Patent: August 16, 2005Assignee: OptiScan Biomedical Corp.Inventors: James R. Braig, Gary E. Hewett, Michael A. Munrow, Julian M. Cortella, Kamrava Azizi, Daniel S. Goldberger
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Publication number: 20040242975Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.Type: ApplicationFiled: August 6, 2002Publication date: December 2, 2004Inventors: Peter Rule, James R. Braig, Daniel S. Goldberger, Julian M. Cortella, Heidi M. Smith, Roger O. Herrera, Kenneth G. Witte, Philip C. Hartstein, Mark D. Agostino
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Publication number: 20040193024Abstract: A method calibrates a monitor that comprises a non-invasive blood constituent monitor and a traditional measurement system. The non-invasive blood constituent monitor includes a thermal gradient inducing element an analyzer window. A traditional monitor output representing a property of a blood constituent is generated by the traditional measurement system. A non-invasive monitor output representing the property of the whole blood constituent is generated by the non-invasive constituent monitor. The traditional monitor output and the non-invasive monitor output are compared to estimate an amount of error. The non-invasive monitor output is corrected by the amount of error.Type: ApplicationFiled: December 18, 2003Publication date: September 30, 2004Inventors: James R. Braig, Peter Rule, Bernhard B. Sterling, Heidi M. Smith, Julian M. Cortella, Jennifer H. Gable
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Publication number: 20040138537Abstract: A solid-state device for the non-invasive generation and capture of thermal gradient spectra from sample tissue. The device includes an infrared transmissive layered window assembly, a means for inducing a thermal gradient in sample tissues. Also provided is an infrared radiation detector for detecting infrared emissions emanating from the tissue as the transient temperature gradient progresses into the sample tissues. The sensor provides output signals proportional to the detected infrared emissions. A data capture means is provided for the sampling of output signals received from the infrared radiation detector as the induced temperature gradient progresses into the sample tissue.Type: ApplicationFiled: October 14, 2003Publication date: July 15, 2004Inventors: James R. Braig, Bernhard B. Sterling, Joan C. Godfrey, Julian M. Cortella, David J. Correia, Charles E. Kramer, Arthur M. Shulenberger
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Publication number: 20040093167Abstract: An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection system has a processor that calculates analyte concentration in accordance with software executable by the processor. Under certain conditions, the software needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.Type: ApplicationFiled: November 8, 2002Publication date: May 13, 2004Inventors: James R. Braig, Gary E. Hewett, Michael A. Munrow, Julian M. Cortella, Kamrava Azizi, Daniel S. Goldberger
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Patent number: 6678542Abstract: A method calibrates a monitor that comprises a non-invasive blood constituent monitor and a traditional measurement system. The non-invasive blood constituent monitor includes a thermal gradient inducing element an analyzer window. A traditional monitor output representing a property of a blood constituent is generated by the traditional measurement system. A non-invasive monitor output representing the property of the whole blood constituent is generated by the non-invasive constituent monitor. The traditional monitor output and the non-invasive monitor output are compared to estimate an amount of error. The non-invasive monitor output is corrected by the amount of error.Type: GrantFiled: November 2, 2001Date of Patent: January 13, 2004Assignee: OptiScan Biomedical Corp.Inventors: James R. Braig, Peter Rule, Bernhard B. Sterling, Heidi M. Smith, Julian M. Cortella, Jennifer H. Gable
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Patent number: 6645142Abstract: A glucose monitoring instrument having network-based communication features which provide a link between patient and practitioner. The glucose monitoring instrument comprises circuitry for communicating data with one or more destination sites on the network which are configured to transmit and receive information to and from the instrument. Instrument measurements are transmitted over the link in addition to information and guidance, to provide increased accuracy, improved program compliance, and patient guidance from a supervisory authority or medical practitioner. In addition, a set of calibration features encourage calibration compliance.Type: GrantFiled: December 1, 2000Date of Patent: November 11, 2003Assignee: OptiScan Biomedical CorporationInventors: James R. Braig, Gary E. Hewett, Michael A. Munrow, Julian M. Cortella, Kamrava Azizi, Daniel S. Goldberger
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Patent number: 6633771Abstract: A solid-state device for the non-invasive generation and capture of thermal gradient spectra from sample tissue. The device includes an infrared transmissive layered window assembly, a means for inducing a thermal gradient in sample tissues. Also provided is an infrared radiation detector for detecting infrared emissions emanating from the tissue as the transient temperature gradient progresses into the sample tissues. The sensor provides output signals proportional to the detected infrared emissions. A data capture means is provided for the sampling of output signals received from the infrared radiation detector as the induced temperature gradient progresses into the sample tissue.Type: GrantFiled: October 25, 1999Date of Patent: October 14, 2003Assignee: OptiScan Biomedical CorporationInventors: James R. Braig, Bernhard B. Sterling, Joan C. Godfrey, Julian M. Cortella, David J. Correia, Charles E. Kramer, Arthur M. Shulenberger
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Publication number: 20030090649Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.Type: ApplicationFiled: January 21, 2002Publication date: May 15, 2003Inventors: Bernhard B. Sterling, Philip C. Hartstein, Kenneth I. Li, Mark D. Agostino, David C. Klonoff, Robert D. Gaffney, Peng Zheng, Jennifer H. Gable, Kenneth G. Witte, Heidi M. Smith, Jane J. Sheill, Mike A. Munrow, W. Dale Hall, Daniel S. Goldberger, Martin J. Fennell, Julian M. Cortella, James R. Braig, Peter Rule
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Publication number: 20030086073Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.Type: ApplicationFiled: July 19, 2002Publication date: May 8, 2003Inventors: James R. Braig, Peter Rule, Robert D. Gaffney, Philip C. Hartstein, Julian M. Cortella, Kenneth I. Li, Bernhard B. Sterling, Peng Zheng, W. Dale Hall, Kenneth G. Witte, Mark D. Agostino, Daniel S. Goldberger
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Publication number: 20030040663Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.Type: ApplicationFiled: August 6, 2002Publication date: February 27, 2003Inventors: Peter Rule, James R. Braig, Daniel S. Goldberger, Julian M. Cortella, Heidi M. Smith, Roger O. Herrera, Kenneth G. Witte, Philip C. Hartstein, Mark D. Agostino
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Publication number: 20030040683Abstract: A device and method for selecting and stabilizing proper sites for the measurement of the concentration of an analyte, for example glucose, within the tissue of a subject or patient are disclosed. One embodiment of the device immobilizes the subject's forearm and finger, thereby stabilizing measurement sites thereon for exposure to a noninvasive monitor which captures analyte concentration data within the subject's skin. The method involves the choice of a location on the subject's body at which to take the analyte measurement, preferably based on the amount of time that has elapsed since the last time the subject ate.Type: ApplicationFiled: July 3, 2002Publication date: February 27, 2003Inventors: Peter Rule, James R. Braig, Daniel S. Goldberger, Julian M. Cortella, Heidi M. Smith, Roger O. Herrera, Kenneth G. Witte, Philip C. Hartstein, Mark D. Agostino
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Publication number: 20030036688Abstract: A method calibrates a monitor that comprises a non-invasive blood constituent monitor and a traditional measurement system. The non-invasive blood constituent monitor includes a thermal gradient inducing element an analyzer window. A traditional monitor output representing a property of a blood constituent is generated by the traditional measurement system. A non-invasive monitor output representing the property of the whole blood constituent is generated by the non-invasive constituent monitor. The traditional monitor output and the non-invasive monitor output are compared to estimate an amount of error. The non-invasive monitor output is corrected by the amount of error.Type: ApplicationFiled: November 2, 2001Publication date: February 20, 2003Inventors: James R. Braig, Peter Rule, Bernhard B. Sterling, Heidi M. Smith, Julian M. Cortella, Jennifer H. Gable
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Publication number: 20030011764Abstract: In accordance with one embodiment there is provided a method of providing a known spectrum to a noninvasive optical detection system of the type having a window for receiving infrared energy. The method comprises affixing a standard to the window. The standard comprises a body formed from a material having known and stable spectral properties. The method further comprises placing at least a portion of the body directly against the window, and operating the optical detection system to detect an emission spectrum of the body. In accordance with another embodiment an infrared spectrometer comprises a window for receiving infrared energy. The window has an exposed surface. The infrared spectrometer further comprises a standard comprising a body formed of a material having known and stable spectral properties. At least part of the body is removably disposed directly against the exposed surface of the window.Type: ApplicationFiled: October 3, 2001Publication date: January 16, 2003Inventors: James R. Braig, Julian M. Cortella, Mike A. Munrow, Kenneth G. Witte, Heidi M. Smith, Philip C. Hartstein, Roger O. Herrera, Peter Rule
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Publication number: 20020068858Abstract: A glucose monitoring instrument having network-based communication features which provide a link between patient and practitioner. The glucose monitoring instrument comprises circuitry for communicating data with one or more destination sites on the network which are configured to transmit and receive information to and from the instrument. Instrument measurements are transmitted over the link in addition to information and guidance, to provide increased accuracy, improved program compliance, and patient guidance from a supervisory authority or medical practitioner. In addition, a set of calibration features encourage calibration compliance.Type: ApplicationFiled: December 1, 2000Publication date: June 6, 2002Inventors: James R. Braig, Gary E. Hewett, Michael A. Munrow, Julian M. Cortella, Kamrava Azizi, Daniel S. Goldberger
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Patent number: 6277096Abstract: A digital fluid delivery and aspiration apparatus with a mechanical de-amplifier for the delivery or removal of discrete volumes of fluidic material from a surgical site. The apparatus has a syringe with a plunger designed to be powered by a pneumatic air supply system. A ratcheting mechanism attached to a pneumatic piston by a mechanical linkage causes the plunger of the syringe to inject discrete doses of the fluidic material into the surgical site or remove discrete amounts of fluidic material from the surgical site. The mechanical linkage increases the force provided to the plunger by the movement of the piston and also de-amplifies the movement of the piston into a lesser movement of the plunger.Type: GrantFiled: June 13, 2000Date of Patent: August 21, 2001Assignee: Medical Instrument Development Laboratories, Inc.Inventors: Julian M. Cortella, Carl C.T. Wang
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Patent number: 6102895Abstract: A digital fluid delivery and aspiration apparatus with a mechanical de-amplifier for the delivery or removal of discrete volumes of fluidic material from a surgical site. The apparatus has a syringe with a plunger designed to be powered by a pneumatic air supply system. A ratcheting mechanism attached to a pneumatic piston by a mechanical linkage causes the plunger of the syringe to inject discrete doses of the fluidic material into the surgical site or remove discrete amounts of fluidic material from the surgical site. The mechanical linkage increases the force provided to the plunger by the movement of the piston and also de-amplifies the movement of the piston into a lesser movement of the plunger.Type: GrantFiled: September 30, 1997Date of Patent: August 15, 2000Inventors: Julian M. Cortella, Carl C. T. Wang