Patents by Inventor Julian M. W. Chan
Julian M. W. Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10610597Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.Type: GrantFiled: June 20, 2017Date of Patent: April 7, 2020Assignees: International Business Machines Corporation, Agency For Science, Technology And Research, Universidad del Pais Vasco/Euskal Herriko UnibersitateaInventors: Julian M. W. Chan, Amanda C. Engler, James L. Hedrick, Haritz Sardon, Jeremy P. K. Tan, Yi Yan Yang
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Patent number: 10023697Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.Type: GrantFiled: November 25, 2016Date of Patent: July 17, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Gregory Breyta, Julian M. W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Alshakim Nelson, Robert J. Ono, Yi Yan Yang, Mu San Zhang
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Publication number: 20170281662Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.Type: ApplicationFiled: June 20, 2017Publication date: October 5, 2017Inventors: Julian M. W. Chan, Amanda C. Engler, James L. Hedrick, Haritz Sardon, Jeremy P. K. Tan, Yi Yan Yang
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Patent number: 9718957Abstract: Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).Type: GrantFiled: January 30, 2015Date of Patent: August 1, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Julian M. W. Chan, James L. Hedrick, Ashlynn L. Z. Lee, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 9717797Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.Type: GrantFiled: December 5, 2013Date of Patent: August 1, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And Research, Universidad del ParĂs Vasco/Euskal Herriko UnibertsitateaInventors: Julian M. W. Chan, Amanda C. Engler, James L. Hedrick, Xiyu Ke, Victor W. L. Ng, Haritz Sardon, Jeremy P. K. Tan, Yi Yan Yang
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Patent number: 9642360Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.Type: GrantFiled: June 25, 2015Date of Patent: May 9, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Julian M. W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Publication number: 20170094964Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.Type: ApplicationFiled: December 19, 2016Publication date: April 6, 2017Inventors: Julian M. W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Publication number: 20170073471Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.Type: ApplicationFiled: November 25, 2016Publication date: March 16, 2017Inventors: Gregory Breyta, Julian M.W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Alshakim Nelson, Robert J. Ono, Yi Yan Yang, Mu San Zhang
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Patent number: 9580554Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.Type: GrantFiled: May 6, 2015Date of Patent: February 28, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Gregory Breyta, Julian M. W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Shaoqiong Liu, Alshakim Nelson, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Publication number: 20160374335Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.Type: ApplicationFiled: June 25, 2015Publication date: December 29, 2016Inventors: Julian M.W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Publication number: 20160326319Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.Type: ApplicationFiled: May 6, 2015Publication date: November 10, 2016Inventors: Gregory Breyta, Julian M.W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Shaoqiong Liu, Alshakim Nelson, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Publication number: 20160220705Abstract: Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).Type: ApplicationFiled: January 30, 2015Publication date: August 4, 2016Inventors: Julian M. W. Chan, James L. Hedrick, Ashlynn L. Z. Lee, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 9062160Abstract: One catalyst-free method of forming a polyurethane comprises forming a first emulsion comprising a first monomer, a surfactant, a water immiscible organic solvent, and water. The first monomer comprises two or more pentafluorophenyl carbonate groups. The first emulsion is combined with an aqueous mixture containing a second monomer comprising two or more nucleophilic amine groups, thereby forming a second emulsion. The first and second monomers of the second emulsion are allowed to react by interfacial polymerization, thereby forming a polyurethane. The polyurethane can have a number average molecular weight (Mn) of about 30000 to about 80000. The method is compatible with introducing pendant functionality into the polyurethane by way of cyclic carbonate precursors to the first monomer.Type: GrantFiled: January 23, 2014Date of Patent: June 23, 2015Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Julian M. W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, James L. Hedrick, Zhan Yuin Ong, Haritz Sardon, Yi Yan Yang
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Publication number: 20150157723Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.Type: ApplicationFiled: December 5, 2013Publication date: June 11, 2015Applicants: International Business Machines Corporation, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, Agency For Science, Technology and ResearchInventors: Julian M. W. Chan, Amanda C. Engler, James L. Hedrick, Xiyu Ke, Victor W.L. Ng, Haritz Sardon, Jeremy P. K. Tan, Yi Yan Yang
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Patent number: 8071573Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.Type: GrantFiled: June 28, 2010Date of Patent: December 6, 2011Assignee: The Board of Trustees of the University of Illinois, a Body Corporate and Politic of the State of IllinoisInventors: John M. Sanders, Yongcheng Song, Julian M. W. Chan, Eric Oldfield, Yonghui Zhang
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Publication number: 20100316676Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.Type: ApplicationFiled: June 28, 2010Publication date: December 16, 2010Inventors: John M. Sanders, Yongcheng Song, Julian M.W. Chan, Eric Oldfield, Yonghui Zhang
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Patent number: 7745422Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.Type: GrantFiled: April 15, 2008Date of Patent: June 29, 2010Assignee: The Board of Trustees of the University of IllinoisInventors: John M. Sanders, Yongcheng Song, Julian M. W. Chan, Eric Oldfield, Yonghui Zhang
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Publication number: 20080318906Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.Type: ApplicationFiled: April 15, 2008Publication date: December 25, 2008Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: John M. Sanders, Yongcheng Song, Julian M. W. Chan, Eric Oldfield, Yonghui Zhang
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Patent number: 7358361Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.Type: GrantFiled: October 7, 2005Date of Patent: April 15, 2008Assignee: The Board of Trustees of the University of IllinoisInventors: John M. Sanders, Yongcheng Song, Julian M. W. Chan, Eric Oldfield, Yonghui Zhang