Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: A computer device providing a computer implemented game, the computer device comprising a user interface configured to detect user input from a user of the game, at least one processor, and a display. A processor is configured to cause a game area to be displayed on the display, comprising a first game object and a plurality of third game objects; cause the first game object to be controlled in response to user input to cause a second game object to hit one or more of the third game objects; cause the hit third game objects to be removed from the game area; and determine when given ones of the third game objects have been removed and in response thereto cause another game area to be displayed, the first game object being moved to a position within the another game area.

Abstract: A machine-learning model is trained using images of structures including defects and images of structures not including defects. Preprocessing is performed on the images before training the machine-learning model. The trained machine-learning model is used to classify defects within images of structures. Images of structures with defects are identified, and the probabilities of the identification/defect classification are obtained.

Abstract: This invention relates to an ex vivo use of the instantaneous frequency modulation (iFM) signal of cardiac activations and to an ex vivo use of the instantaneous amplitude modulation (iAM) signal obtained from the sequence of amplitude excursions of said activations for detecting ‘driver’ or ‘high-hierarchy’ regions and/or the cardiac spots that display the footprint of rotational activations in the heart of a subject with cardiac fibrillation without requiring panoramic simultaneous acquisition.

Abstract: In an embodiment there is provided a game element within a game adapted to be played on data processing apparatus, the method comprising the following steps implemented by at least one processor of the data processing apparatus, displaying a game area having a plurality of game objects on the display, providing a predetermined player object configured for targeting and shooting of the game objects in response to player input, providing predetermined data comprising characteristics of at least one game element, selecting the at least one game element and associated characteristics for display, displaying the at least one game element, and executing the characteristics of said at least one game element in the game in dependence on a trigger event. A computing system, user device and server are also described.

Abstract: A computer device providing a computer implemented game, said computer device comprising: a user interface configured to detect user input from a player of said game; at least one processor; and a display, said at least one processor being configured to: cause a game area to be displayed on said display, said game area comprising a plurality of third game objects; cause at least one second game object to move along a trajectory, wherein when said second game object hits one or more of said third game objects, said respective third game object is removed; and cause an angle of a trajectory of said second game object to be altered to cause said second game object to hit one or more third game objects.

Abstract: A computer device providing a computer implemented game, said computer device comprising: a user interface configured to detect user input from a player of said game; at least one processor; and a display, said at least one processor being configured to: cause a game area to be displayed on said display, said game area comprising a plurality of third game objects; cause at least one second game object to move along a trajectory, wherein when said second game object hits one or more of said third game objects, said respective third game object is removed; and cause an angle of a trajectory of said second game object to be altered to cause said second game object to hit one or more third game objects.

Abstract: A computer device providing a computer implemented game, the computer device comprising a user interface configured to detect user input from a user of the game, at least one processor, and a display. A processor is configured to cause a game area to be displayed on the display, comprising a first game object and a plurality of third game objects; cause the first game object to be controlled in response to user input to cause a second game object to hit one or more of the third game objects; cause the hit third game objects to be removed from the game area; and determine when given ones of the third game objects have been removed and in response thereto cause another game area to be displayed, the first game object being moved to a position within the another game area.

Abstract: In an embodiment there is provided a game element within a game adapted to be played on data processing apparatus, the method comprising the following steps implemented by at least one processor of the data processing apparatus, displaying a game area having a plurality of game objects on the display, providing a predetermined player object configured for targeting and shooting of the game objects in response to player input, providing predetermined data comprising characteristics of at least one game element, selecting the at least one game element and associated characteristics for display, displaying the at least one game element, and executing the characteristics of said at least one game element in the game in dependence on a trigger event. A computing system, user device and server are also described.

Abstract: In an embodiment there is provided a game element within a game adapted to be played on data processing apparatus, the method comprising the following steps implemented by at least one processor of the data processing apparatus, displaying a game area having a plurality of game objects on the display, providing a predetermined player object configured for targeting and shooting of the game objects in response to player input, providing predetermined data comprising characteristics of at least one game element, selecting the at least one game element and associated characteristics for display, displaying the at least one game element, and executing the characteristics of said at least one game element in the game in dependence on a trigger event. A computing system, user device and server are also described.

Abstract: Photovoltaic (PV) assemblies and modules comprising electronic component docking assemblies are described herein. Docking assemblies can comprise a junction box and an electronic component housing configured to be reversibly connected or “docked.” The photovoltaic assemblies and modules described herein facilitate field replacement or removal of electronic components e.g. microinverters from a corresponding module and/or junction box. Additionally, the photovoltaic docking assemblies described herein enable PV modules and arrays with minimal cables and wiring for electrical interconnection.

Abstract: In an embodiment there is provided a game element within a game adapted to be played on data processing apparatus, the method comprising the following steps implemented by at least one processor of said data processing apparatus, displaying a game area having a plurality of game objects on said display, providing a predetermined player object configured for targeting and shooting of said game objects in response to player input, providing predetermined data comprising characteristics of at least one game element, selecting said at least one game element and associated characteristics for display, displaying said at least one game element, and executing said characteristics of said at least one game element in said game in dependence on a trigger event. A computing system, user device and server are also described.

Abstract: Ventral fairing for an aircraft provided between a left wing and a right wing, which comprises a lower central section of convex transverse cross-section located between the left lower surface of the left wing and the right lower surface of the right wing, and with an angle between the cross-section of the fairing and the line of cross-section corresponding to the lower surface of each wing of less than 90 degrees, separate left and right lower lateral sections of concave transverse cross-section which are respectively extended between the lower surface of each wing and the central section; separate first lines of inflection between the lower surface of each wing and the corresponding lateral section; separate second lines of inflection between the lateral sections and the central section.

Abstract: Ventral fairing for an aircraft provided between a left wing (2a) and a right wing (2b), which comprises a lower central section (3a) of convex transverse cross-section located between the left lower surface (2e) of the left wing (2a) and the right lower surface (2f) of the right wing (2b), and with an angle (?) between the cross-section of the fairing (3) and the line of cross-section corresponding to the lower surface (2e, 2f) of each wing (2a, 2b) of less than 90 degrees, separate left (3c) and right (3b) lower lateral sections of concave transverse cross-section which are respectively extended between the lower surface (2e, 2f) of each wing (2a, 2b) and the central section (3a); separate first lines of inflection (4a, 4b) between the lower surface (2e, 2f) of each wing (2a, 2b) and the corresponding lateral section (3c, 3b); separate second lines of inflection (4c, 4d) between the lateral sections (3c, 3b) and the central section (3a).