Abstract: A system or device for skin closure comprises an elastic flat flexible tape elongated along a longitudinal axis and having a lower side and an opposing upper side, said tape having a pressure sensitive adhesive on at least a portion of the lower side, said tape having a plurality of openings arranged side-by-side with spaces between said openings oriented across the longitudinal axis.

Abstract: A wound closure system includes a porous mesh, a first pressure sensitive adhesive (PSA) applied to a top surface of the porous mesh, a removable first liner covering the first PSA, a second PSA applied to a bottom surface of the porous mesh, and a removable second liner covering the second PSA. The second PSA is stronger or denser than the first PSA. A method of using the wound closure system includes removing the second liner to expose the second PSA, pressing the second PSA against skin to approximate wound edges, removing the first liner to expose the first PSA, and pressing a therapeutic device against the first PSA to secure the therapeutic device to the porous mesh. A liquid adhesive is applied over the porous mesh and the therapeutic device, and then cured for binding the porous mesh to skin and binding the therapeutic device to the porous mesh.

Abstract: A surgical incision drape, comprises a flexible substantially flat areal substrate having an upper side and an opposing tissue-facing side, having a longitudinal axis and a pressure sensitive adhesive disposed on the tissue-facing side; at least one hollow microtubular compartment containing a flowable medical agent, said hollow microtubular compartment positioned to intersect the longitudinal axis and embedded into the substrate or positioned on the substrate.

Abstract: A wound closure device and a method of its use are disclosed. The wound closure device comprises a wound closure strip, the wound closure strip comprising a wound-facing side and a top side, the wound-facing side comprises an adhesive applied over at least a portion of the wound facing side of the wound closure strip and a non-symmetric, two-part release liner assembly detachably adhered to the adhesive, the release liner assembly comprising a first section and a second section with the second section comprising a wound closure strip-free portion forming a tab. In an alternate embodiment, the device is multi-segmented and the wound closure strip may be coextensive with the release liner assembly.

Abstract: A wound closure device and a method of its use are disclosed. The wound closure device includes a wound closure strip, the wound closure strip including a wound-facing side and a top side, the wound-facing side comprises an adhesive applied over at least a portion of the wound facing side of the wound closure strip and a non-symmetric, two-part release liner assembly detachably adhered to the adhesive, the release liner assembly including a first section and a second section with the second section including a wound closure strip-free portion forming a tab. In an alternate embodiment, the device is multi-segmented and the wound closure strip may be coextensive with the release liner assembly.

Abstract: Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Abstract: A gas sterilizable syringe includes an enclosure having walls that define a fluid chamber. A flowable material is disposed within the fluid chamber of the enclosure. A plunger is assembled with the enclosure and is moveable toward a distal end of the enclosure for dispensing the flowable material. One or more apertures are formed in at least one of the walls of the enclosure. A gas permeable barrier covers at least one of the apertures formed in at least one of the walls of the enclosure for enabling sterilization gases to pass through the at least one aperture covered by the gas permeable barrier while preventing the flowable material from passing through the at least one of aperture. The gas permeable barrier is permeable to the sterilization gases and impermeable to the flowable material disposed within the fluid chamber of the enclosure.

Abstract: A device for application onto wounds with a liquid rapidly polymerizable adhesive for forming skin closure systems, comprising a thin flexible flat porous tape, preferably a mesh, elongated along a longitudinal axis and having a lower side or wound-facing side and an opposing upper side, a periphery, and central portion in immediate vicinity of the axis; said tape coated or impregnated with an initiator or accelerator of polymerization; said tape having a plurality of elongated traces of soluble pressure sensitive adhesive (PSA) disposed on the wound-facing side; said traces covering from about 3% to about 50% of area of said tape and extending from the periphery to the central portion of said tape.

Abstract: A method of joining together two tissue layers includes positioning a tissue anchor over a first tissue layer. The tissue anchor includes a plate having top and bottom surfaces, an array of first pins projecting from the bottom surface of the plate that oppose the first tissue layer, and an array of second pins projecting from the top surface of the plate that face away from the first tissue layer. A second tissue layer is placed over the first tissue layer and the tissue anchor so that the second pins oppose the second tissue layer. The second tissue layer is pressed onto the tissue anchor and toward the first tissue layer so that the first pins advance into the first tissue layer and the second pins advance into the second tissue layer for joining together the first and second tissue layers. The plate has second pin apertures and the second pins are free to slide and move independently of one another within the second pin apertures.

Abstract: A surgical incision drape, comprises a flexible substantially flat areal substrate having an upper side and an opposing tissue-facing side, having a longitudinal axis and a pressure sensitive adhesive disposed on the tissue-facing side; at least one hollow microtubular compartment containing a flowable medical agent, said hollow microtubular compartment positioned to intersect the longitudinal axis and embedded into the substrate or positioned on the substrate.

Abstract: A surgical incision drape, comprises a flexible substantially flat areal substrate having an upper side and an opposing tissue-facing side, having a longitudinal axis and a pressure sensitive adhesive disposed on the tissue-facing side; at least one hollow microtubular compartment containing a flowable medical agent, said hollow microtubular compartment positioned to intersect the longitudinal axis and embedded into the substrate or positioned on the substrate.

Abstract: A surgical incision drape, comprises a flexible substantially flat areal substrate having an upper side and an opposing tissue-facing side, having a longitudinal axis and a pressure sensitive adhesive disposed on the tissue-facing side; at least one hollow microtubular compartment containing a flowable medical agent, said hollow microtubular compartment positioned to intersect the longitudinal axis and embedded into the substrate or positioned on the substrate.

Abstract: An article, such as a tissue bonding article, includes a flexible material, a polymerization initiator or rate modifier disposed in or on the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material, where the polymerization initiator or rate modifier is a polymerization initiator or rate modifier for the polymerizable adhesive composition.

Abstract: A tissue bonding article includes a flexible material, an adhesive substance applied over at least a portion of a bottom side of the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material.

Abstract: Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Abstract: Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Abstract: A device for application onto incisions or wounds with a liquid rapidly polymerizable adhesive for forming skin closure systems, comprising a flat porous mesh elongated along a longitudinal axis and having an upper side and an opposing lower or wound facing side and a central portion in immediate vicinity of the axis; further having a plurality of pores and windows in said mesh, said windows substantially larger than said pores and arranged along said longitudinal axis in said central portion; a crosslinking or polymerization accelerator or initiator disposed in or on said mesh; and a pressure sensitive adhesive disposed on at least a portion of the lower surface of said mesh.

Abstract: A reinforcing incision drape for tissue, such as fragile tissue, includes an absorbable surgical mesh having top and bottom major surfaces. The absorbable surgical mesh has a stitching zone and first and second reinforcing zones that bound opposite sides of the stitching zone. The stitching zone is less porous and the first and second reinforcing zones are more porous than the stitching zone. A releasable liner covers the top major surface of the absorbable surgical mesh within the stitching zone of the absorbable surgical mesh. A weaker adhesive, such as a pressure sensitive adhesive, covers the bottom major surface of the surgical mesh within the centrally located stitching zone of the absorbable surgical mesh, and a stronger adhesive, such as cyanoacrylite, covers the first and second reinforcing zones of the absorbable surgical mesh.

Abstract: A system for testing substrates includes a first elongated member including an outer end, an inner end, an outer surface that extends between the outer and inner ends, and a concave surface at the inner end, and a second elongated member including an outer end, an inner end, an outer surface that extends between the outer and inner ends of the second elongated member, and a convex surface at the inner end of the second elongated member that opposes the concave surface at the inner end of the first elongated member. A joint interconnects the first and second elongated members for guiding sliding movement of the concave surface of the first elongated member over the convex surface of the second elongated member between extended and flexed positions. A first clamping assembly is coupled with the first elongated member and at least one first clamping assembly spring normally urges the first clamping assembly away from the inner end of the first elongated member.