Patents by Inventor Julian S Kroin

Julian S Kroin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for inhibiting mrp1
    Patent number: 6369070
    Abstract: The present invention relates to a compound of formula (I), which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: April 9, 2002
    Assignee: Eli Lilly and Company
    Inventors: Joseph M. Gruber, Julian S Kroin, Bryan H Norman
  • 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates
    Patent number: 5644043
    Abstract: This invention provides 2',3'-dideoxy-2',2'-difluoronucleosides of the structure ##STR1## wherein R.sup.1 -R.sup.4 are defined in the specification. These compounds have been shown to be useful for treating a variety of vital infections in experimental animals as well as having antineoplastic activity against various mouse tumors.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Julian S. Kroin
  • Anomeric fluororibosyl amines
    Patent number: 5594155
    Abstract: Anomeric 2,2-difluororibosyl azide and amine intermediates which are useful for the preparation of 2'-deoxynucleosides, and processes thereto, are provided. Processes for preparing 2'-deoxynucleosides also are provided.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: January 14, 1997
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Charles D. Jones, Julian S. Kroin, Thomas E. Mabry
  • Methods of treatment using 2',3'-dideoxy-2',2'-difluoronucleosides
    Patent number: 5574021
    Abstract: 2',3'-Dideoxy-2',2'-difluoronucleosides are useful for treating susceptible neoplasms and viral infections in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 12, 1996
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Julian S. Kroin
  • Anomeric fluororibosyl amines
    Patent number: 5541345
    Abstract: Anomeric 2,2-difluororibosyl azide and amine intermediates which are useful for the preparation of 2'-deoxynucleosides, and processes thereto, are provided. Processes for preparing 2'-deoxynucleosides also are provided.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: July 30, 1996
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Charles D. Jones, Julian S. Kroin, Thomas E. Mabry
  • Anomeric fluororibosyl amines
    Patent number: 5480992
    Abstract: Anomeric 2,2-difluororibosyl azide and amine intermediates which are useful for the preparation of 2'-deoxynucleosides, and processes thereto, are provided. Processes for preparing 2'-deoxynucleosides also are provided.
    Type: Grant
    Filed: September 16, 1993
    Date of Patent: January 2, 1996
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Charles D. Jones, Julian S. Kroin, Thomas E. Mabry
  • 2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides, bicyclic derivatives,pharmaceutical compositions, and synthetic precursors
    Patent number: 5430026
    Abstract: The invention provides certain 2-Deoxy-2,2-Difluoro (4-Substituted) Pyrimidine Nucleosides that are effective as anti-cancer agents and in treating viral infections.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: July 4, 1995
    Assignee: Eli Lilly and Company
    Inventors: Larry Hertel, Julian S. Kroin
  • Method of preparing beta-2',2'-difluoronucleosides
    Patent number: 4914028
    Abstract: A process for preparing .beta.-2',2'-difluoronucleosides, and a novel intermediate thereto, are disclosed.
    Type: Grant
    Filed: February 10, 1988
    Date of Patent: April 3, 1990
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Cora Sue Grossman, Julian S. Kroin