Patents by Inventor Julian Spagnuolo

Julian Spagnuolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION
    Publication number: 20230099822
    Abstract: The invention relates to a method for modulating an interaction between an MR1 polypeptide and an MR1-specific T cell receptor molecule, whereby a MR1 polypeptide is contacted with a MR1 ligand compound that is a nucleobase adduct product reflecting a state of metabolic distress of a cell. The invention further relates to the use of compounds identified as MR1 ligands in vaccination or modulation of an MR1-restricted immune response.
    Type: Application
    Filed: January 18, 2021
    Publication date: March 30, 2023
    Applicant: UNIVERSITÄT BASEL
    Inventors: Gennaro DE LIBERO, Lucia MORI, Alessandro VACCHINI, Andrew CHANCELLOR, Julian SPAGNUOLO, Qinmei YANG
  • ANTIBACTERIAL COMBINATIONS
    Publication number: 20210330645
    Abstract: Disclosed herein are antibacterial combinations and compositions that are effective against Gram-negative bacteria. Also disclosed are uses of such combinations and compositions for inhibiting the growth and proliferation of Gram-negative bacteria and/or for killing Gram-negative bacteria and/or for treating a Gram-negative bacterial infection.
    Type: Application
    Filed: September 6, 2019
    Publication date: October 28, 2021
    Inventors: Jasna Rakonjac, Van Hung Vuong Le, Catrina Olivera, Raveen Weerasinghe, Julian Spagnuolo