Patents by Inventor Juliana Layzer

Juliana Layzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-IMMUNOGENIC POEGMA-APTAMER CONJUGATES
    Publication number: 20240131171
    Abstract: Disclosed are POEGMA-aptamer conjugates with a reduced or eliminated host-immune response. An example conjugate includes an aptamer conjugated to a POEGMA having a plurality of side chains, where each side chain includes 1 to 6 monomers of ethylene glycol repeated in tandem. Also disclosed are methods of making the conjugate and methods of using the conjugate. An example method of use includes a method of controlling coagulation in a subject.
    Type: Application
    Filed: February 22, 2022
    Publication date: April 25, 2024
    Inventors: Ashutosh Chilkoti, Bruce Sullenger, Imran Ozer, Angus Hucknall, Juliana Layzer, George Pitoc
  • Von Willebrand Factor (VWF)-targeting agents and methods of using the same
    Patent number: 11965160
    Abstract: Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: April 23, 2024
    Assignees: Duke University, Ohio State Innovation Foundation
    Inventors: Shahid M. Nimjee, Bruce Sullenger, George A. Pitoc, Juliana Layzer
  • VON WILLEBRAND FACTOR (VWF)-TARGETING AGENTS AND METHODS OF USING THE SAME
    Publication number: 20210222170
    Abstract: Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.
    Type: Application
    Filed: January 11, 2021
    Publication date: July 22, 2021
    Applicants: Duke University, Ohio State Innovation Foundation
    Inventors: Shahid M. NIMJEE, Bruce SULLENGER, George A. PITOC, Juliana LAYZER
  • Von Willebrand Factor (VWF)—targeting agents and methods of using the same
    Patent number: 10889816
    Abstract: Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: January 12, 2021
    Assignees: DUKE UNIVERSITY, OHIO STATE INNOVATION FOUNDATION
    Inventors: Shahid M. Nimjee, George A. Pitoc, Juliana Layzer, Bruce Sullenger
  • VON WILLEBRAND FACTOR (VWF)-TARGETING AGENTS AND METHODS OF USING THE SAME
    Publication number: 20190218553
    Abstract: Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.
    Type: Application
    Filed: September 18, 2017
    Publication date: July 18, 2019
    Applicants: DUKE UNIVERSITY, OHIO STATE INNOVATION FOUNDATION
    Inventors: Shahid M. NIMJEE, George A. PITOC, Juliana LAYZER, Bruce SULLENGER
  • Multivalent Immunogen
    Publication number: 20090136522
    Abstract: The present invention relates, in general, to HIV and, in particular, to immunogens that present epitopes located in the membrane external proximal region (MPER) of HIV-I envelope gp41 in multivalent form and to methods of using same.
    Type: Application
    Filed: March 26, 2007
    Publication date: May 28, 2009
    Inventors: Barton F. Haynes, Michael Moody, Laurent Verkozcy, Bruce A. Sullenger, Juliana Layzer