Abstract: Polypeptides which can provide a senotherapeutic effect are provided herein. The polypeptides can be formulated for topical application and can be applied topically to a subject to provide a senotherapeutic effect in the subject or in the cells of the subject.

Abstract: The disclosure relates to systems, software and methods for gerontological classification of subjects based on a detection of a plurality of epigenetic markers such as methylation status of nucleotides (e.g., CpG) in the genomic DNA.

Abstract: In one aspect, a method for identifying age-preventing agents for skin is disclosed. Skin samples are transferred to a first vessel, a second vessel, and a third vessel. A skin age inducing agent is applied to the skin samples in the first vessel and the second vessel. A prospective age-preventing agent is applied to the skin sample in the first vessel. Genetic material is extracted from the skin samples in the first vessel, the second vessel and the third vessel. A quantity of a skin age biomarker is measured in the extracted genetic material from each vessel. A score is determined for the skin samples in the first vessel, the second vessel and the third vessel based on the quantity of skin age biomarker measured in the genetic material extracted from the skin sample in each vessel, wherein the score is indicative of a condition of the skin sample in each vessel.