Patents by Inventor Juliane Bubeck-Wardenburg

Juliane Bubeck-Wardenburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST STAPHYLOCOCCUS AUREUS
    Publication number: 20230295246
    Abstract: Among the various aspects of the present disclosure relates to methods and compositions useful to reduce or prevent tolerogenic or suppressive T-cell responses in a subject to a bacterial pathogen. The methods include exposing the subject to an modified bacterial antigen prior to the first exposure of the subject to the bacterial pathogen. The vaccination strategy is capable of neutralizing Hla to provide immunoprotection against S. aureus infections.
    Type: Application
    Filed: December 21, 2020
    Publication date: September 21, 2023
    Inventors: Juliane Bubeck Wardenburg, Brandon Lee, Reuben Olaniyi
  • Methods and compositions related to immunizing against lung diseases and conditions
    Patent number: 11639379
    Abstract: Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing Hla to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a Hla with reduced toxicity, represented by a recombinant mutant form of Hla (HlaH35L) in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: May 2, 2023
    Assignee: The University of Chicago
    Inventors: Juliane Bubeck-Wardenburg, Olaf Schneewind
  • Methods and Compositions Related to Immunizing Against Staphylococcal Lung Diseases and Conditions
    Publication number: 20210155678
    Abstract: Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing Hla to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a Hla with reduced toxicity, represented by a recombinant mutant form of Hla (HlaH35L) in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
    Type: Application
    Filed: May 19, 2020
    Publication date: May 27, 2021
    Applicant: The University of Chicago
    Inventors: Juliane Bubeck-Wardenburg, Olaf Schneewind
  • Methods and compositions using ADAM10 inhibitors to treat bacterial infections
    Patent number: 10472391
    Abstract: Certain embodiments are directed to compositions and methods of inhibiting a pathogenic bacterial infection involving ADAM10, specifically a method for treating pore-forming toxin-inducted pathology caused by exposure to staphylococcus in a subject, comprising administering an effective amount of a ADAM10 inhibitor to a patient. The methods include treating pneumonia or inhibiting disruption to epithelial barrier in a subject, having or at risk of developing staphylococcal infection.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: November 12, 2019
    Assignees: THE UNIVERSITY OF CHICAGO, SRI INTERNATIONAL
    Inventors: Juliane Bubeck Wardenburg, Katherine Weh, Leyi Gong
  • METHODS AND COMPOSITIONS USING ADAM10 INHIBITORS TO TREAT BACTERIAL INFECTIONS
    Publication number: 20160052964
    Abstract: Certain embodiments are directed to compositions and methods of inhibiting a pathogenic bacterial infection involving ADAM10, specifically a method for treating pore-forming toxin-inducted pathology caused by exposure to staphylococcus in a subject, comprising administering an effective amount of a ADAM10 inhibitor to a patient. The methods include treating pneumonia or inhibiting disruption to epithelial barrier in a subject, having or at risk of developing staphylococcal infection.
    Type: Application
    Filed: April 4, 2014
    Publication date: February 25, 2016
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Juliane Bubeck WARDENBURG, Katherine SCHMALZER
  • Methods and Compositions Related to Immunizing Against Staphylococcal Lung Diseases and Conditions
    Publication number: 20160046698
    Abstract: Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing Hla to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a Hla with reduced toxicity, represented by a recombinant mutant form of Hla (HlaH35L) in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
    Type: Application
    Filed: September 1, 2015
    Publication date: February 18, 2016
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Juliane Bubeck-Wardenburg, Olaf Schneewind
  • Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
    Patent number: 9181329
    Abstract: Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing HIa to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a HIa with reduced toxicity, represented by a recombinant mutant form of HIa (HlaH35L) in which histidine 35 is convened to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: November 10, 2015
    Assignee: The University of Chicago
    Inventors: Juliane Bubeck-Wardenburg, Olaf Schneewind
  • Role of ADAM10 and its relevance to disease and therapeutics
    Patent number: 9150865
    Abstract: Certain embodiments are directed to compositions and methods of inhibiting pathogenic bacterial infection involving ADAMIO comprising administering an effective amount of a metalloprotease inhibitor to a patient. Certain embodiments are directed to method of inhibiting Staphylococcal infection comprising administering an effective amount of a metalloprotease inhibitor to a patient. Other embodiments concern methods of inhibiting infection by a bacteria from the genus Clostridium, Streptococcus, Listeria, Bacillus, or Arcanobacterium.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: October 6, 2015
    Assignee: The University of Chicago
    Inventor: Juliane Bubeck Wardenburg
  • Methods and compositions related to immunizing against lung disease and conditions
    Patent number: 8840906
    Abstract: Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing HIa to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a HIa with reduced toxicity, represented by a recombinant mutant form of HIa (HlaH35L) in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: September 23, 2014
    Assignee: The University of Chicago
    Inventors: Juliane Bubeck-Wardenburg, Olaf Schneewind, Brook Ragle
  • ROLE OF ADAM10 AND ITS RELEVANCE TO DISEASE AND THERAPEUTICS
    Publication number: 20140178399
    Abstract: Certain embodiments are directed to compositions and methods of inhibiting pathogenic bacterial infection involving ADAMIO comprising administering an effective amount of a metalloprotease inhibitor to a patient. Certain embodiments are directed to method of inhibiting Staphylococcal infection comprising administering an effective amount of a metalloprotease inhibitor to a patient. Other embodiments concern methods of inhibiting infection by a bacteria from the genus Clostridium, Streptococcus, Listeria, Bacillus, or Arcanobacterium.
    Type: Application
    Filed: November 9, 2011
    Publication date: June 26, 2014
    Applicant: University of Chicago
    Inventor: Juliane Bubeck Wardenburg
  • Methods and Compositions Related to Immunizing Against Staphylococcal Lung Diseases and Conditions
    Publication number: 20110027265
    Abstract: Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing HIa to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a HIa with reduced toxicity, represented by a recombinant mutant form of HIa (HlaH35L) in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
    Type: Application
    Filed: August 29, 2008
    Publication date: February 3, 2011
    Applicant: The University of Chicago
    Inventors: Juliane Bubeck-Wardenburg, Olaf Schneewind, Brook Ragle