Abstract: An intraoral tomosynthesis x-ray imaging device, system, and method with an interchangeable collimator. The intraoral tomosynthesis x-ray imaging device includes an x-ray source array including one or more spatially distributed focal spots and a detachable collimation assembly to provide rectangular or circular radiation fields. The intraoral tomosynthesis x-ray imaging device further includes a digital intraoral x-ray detector. In some embodiments, the x-ray source array is configured to produce either a scanning x-ray beam illuminating an object from different viewing angles without mechanically moving the x-ray source array for tomosynthesis, or a single two-dimensional radiograph.