Patents by Inventor Julianne C. Griepenburg

Julianne C. Griepenburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transcriptome in vivo analysis (TIVA) and transcriptome in situ analysis (TISA)
    Patent number: 11873312
    Abstract: Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: January 16, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James Eberwine, Ivan J. Dmochowski, Sean B. Yeldell, Julianne C. Griepenburg, Teresa L. Rapp, Jennifer M. Singh, Jai-Yoon Sul, Jaehee Lee
  • Transcriptome In Vivo Analysis (TIVA) and Transcriptome In Situ Analysis (TISA)
    Publication number: 20210292352
    Abstract: Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.
    Type: Application
    Filed: May 28, 2021
    Publication date: September 23, 2021
    Inventors: James Eberwine, Ivan J. Dmochowski, Sean B. Yeldell, Julianne C. Griepenburg, Teresa L. Rapp, Jennifer M. Singh, Jai-Yoon Sul, Jaehee Lee
  • Ruthenium-based photolinkers and methods of use
    Patent number: 11046721
    Abstract: The present invention provides ruthenium-based photolinker compounds, caged molecules comprising the ruthenium-based photolinker compounds, and methods of use. In certain aspects, the compositions disclosed herein comprise an active domain conjugated to a ruthenium-based photolinker, such that irradiation of the photolinker exposes the active domain.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: June 29, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ivan J. Dmochowski, Julianne C. Griepenburg, Teresa L. Rapp
  • Transcriptome in vivo analysis (TIVA) and transcriptome in situ analysis (TISA)
    Patent number: 11021502
    Abstract: Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: June 1, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James Eberwine, Ivan J. Dmochowski, Sean B. Yeldell, Julianne C. Griepenburg, Teresa L. Rapp, Jennifer M. Singh, Jai-Yoon Sul, Jaehee Lee
  • Ruthenium-Based Photolinkers and Methods of Use
    Publication number: 20170260221
    Abstract: The present invention provides ruthenium-based photolinker compounds, caged molecules comprising the ruthenium-based photolinker compounds, and methods of use. In certain aspects, the compositions disclosed herein comprise an active domain conjugated to a ruthenium-based photolinker, such that irradiation of the photolinker exposes the active domain.
    Type: Application
    Filed: August 4, 2015
    Publication date: September 14, 2017
    Inventors: Ivan J. Dmochowski, Julianne C. Griepenburg, Teresa L. Rapp
  • Transcriptome In Vivo Analysis (TIVA) and Transcriptome In Situ Analysis (TISA)
    Publication number: 20170253876
    Abstract: Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.
    Type: Application
    Filed: August 4, 2015
    Publication date: September 7, 2017
    Inventors: James Eberwine, Ivan J. Dmochowski, Sean B. Yeldell, Julianne C. Griepenburg, Teresa L. Rapp, Jennifer M. Singh, Jai-Yoon Sul, Jaehee Lee