Patents by Inventor Julianne M Gibbs-Davis

Julianne M Gibbs-Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid amplification by a destabilization method
    Patent number: 9193993
    Abstract: The invention is directed to a method for isothermally amplifying a DNA sequence involving hybridizing a destabilizing DNA template to complementary nucleotide fragments to form a first nicked duplex; ligating the first nicked duplex to form a product duplex comprising the DNA sequence and the template, wherein the product duplex is capable of dissociating to release the DNA sequence and the template; and repeating these steps to generate multiple copies of the template and the DNA sequence. Further, the method may also involve hybridizing the DNA sequence to complementary destabilizing fragments or probes to form a second nicked duplex; ligating the second nicked duplex to form the product duplex comprising the DNA sequence and the template, wherein the product duplex dissociates to release the DNA sequence and the template; and repeating these steps to generate multiple copies of the template and the DNA sequence.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: November 24, 2015
    Inventors: Julianne M Gibbs-Davis, Rosalie Dawn McKay, Yimeng Li, Jade Lam, Abu Kausar, Catherine Jennifer Mitran