Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.

Abstract: The present disclosure describes various embodiments of systems, apparatuses, and methods for automated sensing clinical documentation using machine learning. One such method comprises recording a video data feed of a patient being attended to by a medical personnel that is wearing at least one motion sensor; capturing a motion data feed of the medical personnel as the patient is being attended to by the medical personnel; analyzing the collected data feeds to prepare a clinical care record using machine learning algorithms; and transmitting the clinical care record to an upstream healthcare provider. Other methods and systems are also provided.

Abstract: This disclosure provides a technology for users to gain first-hand knowledge and experience with interpreting whole genomes. The technology graphically depicts variations in genome sequences in an expandable display, and provides a platform whereby the user may find and research the biological significance of such variants. The technology also provides a unique collaborative environment designed to capture and improve the collective knowledge of the participating community.

Abstract: This disclosure provides a technology for users to gain first-hand knowledge and experience with interpreting whole genomes. The technology graphically depicts variations in genome sequences in an expandable display, and provides a platform whereby the user may find and research the biological significance of such variants. The technology also provides a unique collaborative environment designed to capture and improve the collective knowledge of the participating community.

Abstract: This disclosure provides a technology for users to gain first-hand knowledge and experience with interpreting whole genomes. The technology graphically depicts variations in genome sequences in an expandable display, and provides a platform whereby the user may find and research the biological significance of such variants. The technology also provides a unique collaborative environment designed to capture and improve the collective knowledge of the participating community.

Abstract: Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied.

Abstract: In an exemplary sharpening element storage embodiment of the present invention, a sharpening element (5000) may be inserted in a groove (5001) that would be provided in an interior wall (5004) of a knife handle (or knife blade housing) (5005). When the first notch (5002), located in the blade's tongue (5003), in the knife blade (5006) is aligned with the conforming shape of the first end (5008) of the groove (5001), it would be possible to move the sharpening element (5000) in the direction of the opposing handle part (not shown), out from the groove (5001), in order to extract the sharpening element (5000) completely out from the knife handle (5005) for use.

Abstract: Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied.

Abstract: A radio frequency mechanical filter (10) of the resonant type employs a plurality of parallel spaced-apart resonators (40) disposed within a housing (16) defining a cavity. The resonators are supported at their first ends (46) to one wall (20) of the housing (16), with the remaining ends of the resonators being unsupported. A TEFLON support bracket (12) is disposed across the resonators (40) at points between the ends (44, 46) of the resonators. In one form, the support bracket (12) is movable along the length of the resonators to change the center frequency and bandwidth response of the filter.